The pyruvate dehydrogenase complexes: structure-based function and regulation

The pyruvate dehydrogenase complexes (PDCs) from all known living organisms comprise three principal catalytic components for their mission: E1 and E2 generate acetyl-coenzyme A, whereas the FAD/NAD(+)-dependent E3 performs redox recycling. Here we compare bacterial (Escherichia coli) and human PDCs...

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Bibliographic Details

Published in:	The Journal of biological chemistry Vol. 289; no. 24; p. 16615
Main Authors:	Patel, Mulchand S, Nemeria, Natalia S, Furey, William, Jordan, Frank
Format:	Journal Article
Language:	English
Published:	United States 13.06.2014
Subjects:	Amino Acid Sequence Animals Catalytic Domain Escherichia coli - enzymology Humans Molecular Sequence Data Protein Binding Pyruvate Dehydrogenase Complex - chemistry Pyruvate Dehydrogenase Complex - metabolism Pyruvate Dehydrogenase Complex (PDC) Pyruvate Dehydrogenase Kinase (PDC Kinase) Covalent Regulation Enzyme Catalysis Protein-Protein Interaction
ISSN:	1083-351X, 1083-351X
Online Access:	Get more information
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