Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease

To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors (PPAR)-δ agonist treatment in nonalcoholic fatty liver disease (NAFLD) models. Male C57BL/6J mice were classified according to control or high fat diet (HFD) with or without PPAR-δ agonist (GW) over...

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Veröffentlicht in:	World journal of gastroenterology : WJG Jg. 21; H. 45; S. 12787 - 12799
Hauptverfasser:	Lee, Hyun Jung, Yeon, Jong Eun, Ko, Eun Jung, Yoon, Eileen L, Suh, Sang Jun, Kang, Keunhee, Kim, Hae Rim, Kang, Seoung Hee, Yoo, Yang Jae, Je, Jihye, Lee, Beom Jae, Kim, Ji Hoon, Seo, Yeon Seok, Yim, Hyung Joon, Byun, Kwan Soo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 07.12.2015
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Blood Glucose - drug effects Blood Glucose - metabolism Cytoprotection Diet, High-Fat Disease Models, Animal Gene Expression Regulation Hep G2 Cells Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology Humans Inflammasomes - antagonists & inhibitors Inflammasomes - genetics Inflammasomes - metabolism Inflammation Mediators - metabolism Lipopolysaccharides Liver - drug effects Liver - metabolism Liver - pathology Male Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Non-alcoholic Fatty Liver Disease - prevention & control Oxidative Stress - drug effects Palmitic Acid - toxicity PPAR delta - agonists PPAR delta - metabolism Signal Transduction - drug effects Thiazoles - pharmacology Time Factors Nucleotide-binding and oligomerization domain-like receptor Inflammasome Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Peroxisome proliferator-activated receptors delta
ISSN:	2219-2840
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