Molecular Epidemiology of Human Metapneumovirus Infections in Children from San Luis Potosí-Mexico

Lower respiratory infections are a leading cause of death in children under five years. Human metapneumovirus (HMPV) is an underestimated causal agent of these infections. In this study, the molecular epidemiology of HMPV associated with respiratory infections in Mexican children between August 2023...

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Bibliographic Details
Published in:Viruses Vol. 17; no. 10; p. 1338
Main Authors: Martínez-Marrero, Nadia, Muñoz-Escalante, Juan Carlos, Yerena-Rivera, Jan Michell, Jaime-Rocha, Luis Rubén, Leija-Martínez, José J., González-Ortiz, Ana María, Noyola, Daniel E.
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 02.10.2025
Subjects:
acute respiratory infections
Amino acids
Child
Child, Preschool
Children
Epidemiology
Female
Genotype
Genotype & phenotype
Genotypes
Glycoproteins
Glycosylation
human metapneumovirus
Humans
Infant
Infection
Infections
Male
Medical research
Medicine, Experimental
Metapneumovirus - classification
Metapneumovirus - genetics
Metapneumovirus - isolation & purification
Mexico - epidemiology
Molecular Epidemiology
Pandemics
Paramyxoviridae Infections - epidemiology
Paramyxoviridae Infections - virology
Pediatrics
Phylogenetics
Phylogeny
Pneumovirus
Protein arrays
Respiratory diseases
Respiratory tract diseases
Respiratory tract infection
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - virology
Viruses
Mexico
United States
Massachusetts
Spain
India
United States > US
molecular epidemiology
glycosylation
Pneumovirus
human metapneumovirus
acute respiratory infections
ISSN:1999-4915, 1999-4915
Online Access:Get full text
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Summary:Lower respiratory infections are a leading cause of death in children under five years. Human metapneumovirus (HMPV) is an underestimated causal agent of these infections. In this study, the molecular epidemiology of HMPV associated with respiratory infections in Mexican children between August 2023 and August 2024 was determined. Sequences were also analyzed for predicted N- and O-linked glycosylation sites. Overall, 34 sequences from infants with respiratory infections were obtained; 32 were assigned to the A2b2 genotype, one to A2b1, and one to B2. All but one of the A2b2 sequences carried the 111-nucleotide duplication of the G gene; the remaining sequence carried the 180-nucleotide duplication. The samples assigned to the A2b1 and B2 genotypes did not have a duplication. The HMPV-A phylogeny did not show a clustering of Mexican sequences as a single monophyletic group. Four N-linked glycosylation sites were predicted in the HMPV-A sequences and three in the B sequence. The number of O-linked glycosylation sites predicted in HMPV-A ranged from 61 to 77 and were 61 in the HMPV-B sequence. This first description of HMPV genotypes and the diverse array of G protein N- and O-linked glycosylation patterns found in a Mexican pediatric population in the post-pandemic period contributes to the understanding of the global spread of HMPV.
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ISSN:1999-4915
1999-4915
DOI:10.3390/v17101338