RET gene rearrangements occur in a subset of pancreatic acinar cell carcinomas

Pancreatic acinar cell carcinoma is relatively rare (1 to 2% of pancreatic malignancies) but may be under-recognized. In contrast to pancreatic ductal adenocarcinoma, most acinar cell carcinomas lack mutations in KRAS , DPC , CDKN2A or TP53 , but appear to have a high incidence of gene rearrangement...

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Bibliographic Details
Published in:	Modern pathology Vol. 33; no. 4; pp. 657 - 664
Main Authors:	Chou, Angela, Brown, Ian S., Kumarasinghe, M. Priyanthi, Perren, Aurel, Riley, Denise, Kim, Yoomee, Pajic, Marina, Steinmann, Angela, Rathi, Vivek, Jamieson, Nigel B., Verheij, Joanne, van Roessel, Stijn, Nahm, Chris B., Mittal, Anubhav, Samra, Jaswinder, Gill, Anthony J.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.04.2020 Elsevier Limited
Subjects:	14/32 692/53/2421 692/53/2423 692/699/67/1504/1713 82/51 Adenocarcinoma Adolescent Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics Carcinoma, Acinar Cell - genetics Carcinoma, Acinar Cell - pathology Clinical trials Databases, Factual Europe Female Gene Rearrangement Genetic Predisposition to Disease Humans Hybridization In Situ Hybridization, Fluorescence Laboratory Medicine Male Medicine Medicine & Public Health Middle Aged Neuroendocrine tumors p53 Protein Pancreas Pancreatic cancer Pancreatic carcinoma Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Pathology Protein-tyrosine kinase Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins c-ret - genetics Ret protein Tumors Young Adult Europe
ISSN:	0893-3952, 1530-0285, 1530-0285
Online Access:	Get full text
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