The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor

Evidence indicates that endosomal entry promotes signaling by the Notch receptor, but the mechanisms involved are not clear. In a search for factors that regulate Notch activation in endosomes, we isolated mutants in Drosophila genes that encode subunits of the vacuolar ATPase (V-ATPase) proton pump...

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Bibliographic Details
Published in:	Development (Cambridge) Vol. 137; no. 11; p. 1825
Main Authors:	Vaccari, Thomas, Duchi, Serena, Cortese, Katia, Tacchetti, Carlo, Bilder, David
Format:	Journal Article
Language:	English
Published:	England 01.06.2010
Subjects:	Animals Animals, Genetically Modified Drosophila - genetics Drosophila - growth & development Drosophila - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Endosomes - metabolism Eye - growth & development Eye - metabolism Eye - ultrastructure Genes, Insect Hydrogen-Ion Concentration Lysosomes - metabolism Microscopy, Electron, Transmission Mutation Receptors, Notch - genetics Receptors, Notch - metabolism Signal Transduction Vacuolar Proton-Translocating ATPases - genetics Vacuolar Proton-Translocating ATPases - metabolism
ISSN:	1477-9129, 1477-9129
Online Access:	Get more information
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