Absorption and evaporation of N, N-diethyl- m-toluamide from human skin in vitro

The penetration of DEET through split-thickness cadaver skin was measured in non-occluded Franz cells placed either in a fume hood or on a laboratory workbench. DEET, dissolved in a small volume of ethanol and spiked with 14C radiolabel was applied to skin at doses from 0.02 to 11 000 μg/cm 2. DEET...

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Bibliographic Details
Published in:	Toxicology and applied pharmacology Vol. 204; no. 1; pp. 81 - 90
Main Authors:	Santhanam, Arjun, Miller, Matthew A., Kasting, Gerald B.
Format:	Journal Article
Language:	English
Published:	San Diego, CA Elsevier Inc 01.04.2005 Elsevier
Subjects:	60 APPLIED LIFE SCIENCES Abdomen Back BENZYL ALCOHOL Benzyl Alcohol - pharmacokinetics Biological and medical sciences CARBON 14 Carbon Radioisotopes DEET DEET - pharmacokinetics Diffusion ETHANOL EVAPORATION EVAPORATION MODEL FUME HOODS Humans IN VITRO In Vitro Techniques Insect Repellents - pharmacokinetics LABELLED COMPOUNDS MASS TRANSFER Mathematical model Medical sciences Models, Biological Percutaneous absorption PERMEABILITY RADIOACTIVITY SKIN Skin - metabolism Skin Absorption - drug effects Thigh Toxicology Ventilation Volatilization Percutaneous absorption Skin Evaporation Mathematical model DEET Diethyltoluamide Human Absorption Repellent In vitro Percutaneous route
ISSN:	0041-008X, 1096-0333
Online Access:	Get full text
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