Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

Ferroptosis, a form of regulated cell death, is initiated by oxidative perturbations of the intracellular microenvironment, which is under the constitutive control of glutathione peroxidase 4 (GPX4). Ferrous iron (Fe2+) accumulation and lipid peroxidation are critical events in the induction of ferr...

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Vydáno v:	Cancer letters Ročník 483; s. 127 - 136
Hlavní autoři:	Su, Yanwei, Zhao, Bin, Zhou, Liangfu, Zhang, Zheyuan, Shen, Ying, Lv, Huanhuan, AlQudsy, Luban Hamdy Hameed, Shang, Peng
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Ireland Elsevier B.V 28.07.2020 Elsevier Limited
Témata:	Acetaminophen Alcohol Amino acids Animals Antibiotics Antineoplastic Agents - therapeutic use Antioxidants Apoptosis Artesunate Autophagy Cancer Cancer therapies Cell death Cell proliferation Chelating agents Cisplatin Drug development Fatty acids Ferritinophagy Ferroptosis Ferroptosis - drug effects Fibroblasts Free radicals Glutathione Glutathione peroxidase Glutathione peroxidase 4 Humans Immunomodulators Inhibitor drugs Iron Lipid peroxidation Lipid Peroxidation - drug effects Lipids Lipophilic Metabolism Mitochondria Morphology Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Oxidation Oxidative Stress - drug effects Phospholipid Hydroperoxide Glutathione Peroxidase - metabolism Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Roles Salinomycin Signal Transduction Sulfasalazine System xc Targeted cancer therapy Tumor Microenvironment Vitamin E System xc Ferritinophagy Reactive oxygen species Iron Glutathione peroxidase 4 System x(c)(-)
ISSN:	0304-3835, 1872-7980, 1872-7980
On-line přístup:	Získat plný text
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