Memantine augmentation for refractory obsessive–compulsive disorder

Glutamatergic hyperactivity hypothesis in obsessive–compulsive disorder (OCD) has been proposed but not tested. Memantine is an uncompetitive N-methyl- d-aspartate (NMDA) receptor antagonist. We report two cases of refractory obsessive–compulsive disorder treated with an augmentation of memantine at...

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Vydáno v:	Progress in neuro-psychopharmacology & biological psychiatry Ročník 30; číslo 6; s. 1173 - 1175
Hlavní autoři:	Pasquini, Massimo, Biondi, Massimo
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Amsterdam Elsevier Inc 30.08.2006 Elsevier
Témata:	Adult Adult and adolescent clinical studies Anxiety disorders. Neuroses Biological and medical sciences Drug Resistance Drug Therapy, Combination Excitatory Amino Acid Antagonists - therapeutic use Female Glutamatergic transmission Humans Male Medical sciences Memantine Memantine - therapeutic use Memory for actions Middle Aged Neuropharmacology Obsessive-Compulsive Disorder - drug therapy Obsessive-Compulsive Disorder - psychology Obsessive-compulsive disorders Obsessive–compulsive disorder Pharmacology. Drug treatments Psychiatric Status Rating Scales Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Serotonin Uptake Inhibitors - therapeutic use Obsessive–compulsive disorder Memantine Glutamatergic transmission Memory for actions Obsessive compulsive disorder Memory Anxiety disorder Glutamate receptor Antialzheimer agent Antiparkinson agent Amantadine dérivatives Obsessive-compulsive disorder Antagonist NMDA receptor
ISSN:	0278-5846, 1878-4216
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