Memantine augmentation for refractory obsessive–compulsive disorder
Glutamatergic hyperactivity hypothesis in obsessive–compulsive disorder (OCD) has been proposed but not tested. Memantine is an uncompetitive N-methyl- d-aspartate (NMDA) receptor antagonist. We report two cases of refractory obsessive–compulsive disorder treated with an augmentation of memantine at...
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| Published in: | Progress in neuro-psychopharmacology & biological psychiatry Vol. 30; no. 6; pp. 1173 - 1175 |
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| Language: | English |
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| ISSN: | 0278-5846, 1878-4216 |
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| Abstract | Glutamatergic hyperactivity hypothesis in obsessive–compulsive disorder (OCD) has been proposed but not tested. Memantine is an uncompetitive
N-methyl-
d-aspartate (NMDA) receptor antagonist. We report two cases of refractory obsessive–compulsive disorder treated with an augmentation of memantine at 15 mg/day. The first case did not benefit from such treatment, while the second showed immediate and substantial improvement. Contrasting results, reflecting different subtypes of OCD, are discussed. We hypothesized that in certain OCD subtypes an agent that enhances memory for actions may promote a reduction in orbitofrontal activation. |
|---|---|
| AbstractList | Glutamatergic hyperactivity hypothesis in obsessive–compulsive disorder (OCD) has been proposed but not tested. Memantine is an uncompetitive
N-methyl-
d-aspartate (NMDA) receptor antagonist. We report two cases of refractory obsessive–compulsive disorder treated with an augmentation of memantine at 15 mg/day. The first case did not benefit from such treatment, while the second showed immediate and substantial improvement. Contrasting results, reflecting different subtypes of OCD, are discussed. We hypothesized that in certain OCD subtypes an agent that enhances memory for actions may promote a reduction in orbitofrontal activation. Glutamatergic hyperactivity hypothesis in obsessive-compulsive disorder (OCD) has been proposed but not tested. Memantine is an uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist. We report two cases of refractory obsessive-compulsive disorder treated with an augmentation of memantine at 15 mg/day. The first case did not benefit from such treatment, while the second showed immediate and substantial improvement. Contrasting results, reflecting different subtypes of OCD, are discussed. We hypothesized that in certain OCD subtypes an agent that enhances memory for actions may promote a reduction in orbitofrontal activation. Glutamatergic hyperactivity hypothesis in obsessive-compulsive disorder (OCD) has been proposed but not tested. Memantine is an uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist. We report two cases of refractory obsessive-compulsive disorder treated with an augmentation of memantine at 15 mg/day. The first case did not benefit from such treatment, while the second showed immediate and substantial improvement. Contrasting results, reflecting different subtypes of OCD, are discussed. We hypothesized that in certain OCD subtypes an agent that enhances memory for actions may promote a reduction in orbitofrontal activation.Glutamatergic hyperactivity hypothesis in obsessive-compulsive disorder (OCD) has been proposed but not tested. Memantine is an uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist. We report two cases of refractory obsessive-compulsive disorder treated with an augmentation of memantine at 15 mg/day. The first case did not benefit from such treatment, while the second showed immediate and substantial improvement. Contrasting results, reflecting different subtypes of OCD, are discussed. We hypothesized that in certain OCD subtypes an agent that enhances memory for actions may promote a reduction in orbitofrontal activation. |
| Author | Biondi, Massimo Pasquini, Massimo |
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| Keywords | Obsessive–compulsive disorder Memantine Glutamatergic transmission Memory for actions Obsessive compulsive disorder Memory Anxiety disorder Glutamate receptor Antialzheimer agent Antiparkinson agent Amantadine dérivatives Obsessive-compulsive disorder Antagonist NMDA receptor |
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| References | Poyurovsky, Weizman, Weizman, Koran (bib12) 2005; 162 Zitterl, Urban, Linzmayer, Aigner, Demal, Semler (bib17) 2001; 34 Pasquini, Garavini, Biondi (bib10) 2005; 29 Araki, Suemaru, Gomita (bib2) 2002; 88 Mansvelder, Keath, McGehee (bib9) 2002; 33 Kumar (bib6) 2004; 52 Lundberg, Carlsson, Norfeldt, Carlsson (bib8) 2004; 28 Tallis, Pratt, Jamani (bib14) 1999; 37 Girod, Barazangi, McGehhe, Role (bib4) 2000; 39 Kuipers, Trentani, ter Horst, den Boer (bib5) 2005 Salkovskis (bib13) 1999; 37 S Zarate, Singh, Quiroz, De Jesus, Denicoff, Luckenbaugh (bib16) 2006; 163 Aracava, Pereira, Maelicke, Albuquerque (bib1) 2005; 312 Lochner, Stein (bib7) 2003; 11 Pujol, Torres, Deus, Cardoner, Pifarre, Capdevila (bib11) 1999; 45 Tolin, Abramowitz, Brigidi, Amir, Street, Foa (bib15) 2001; 39 Carlsson (bib3) 2001; 25 Araki (10.1016/j.pnpbp.2006.04.013_bib2) 2002; 88 Girod (10.1016/j.pnpbp.2006.04.013_bib4) 2000; 39 Tallis (10.1016/j.pnpbp.2006.04.013_bib14) 1999; 37 Zitterl (10.1016/j.pnpbp.2006.04.013_bib17) 2001; 34 Salkovskis (10.1016/j.pnpbp.2006.04.013_bib13) 1999; 37 S Kumar (10.1016/j.pnpbp.2006.04.013_bib6) 2004; 52 Pasquini (10.1016/j.pnpbp.2006.04.013_bib10) 2005; 29 Aracava (10.1016/j.pnpbp.2006.04.013_bib1) 2005; 312 Mansvelder (10.1016/j.pnpbp.2006.04.013_bib9) 2002; 33 Poyurovsky (10.1016/j.pnpbp.2006.04.013_bib12) 2005; 162 Lundberg (10.1016/j.pnpbp.2006.04.013_bib8) 2004; 28 Zarate (10.1016/j.pnpbp.2006.04.013_bib16) 2006; 163 Pujol (10.1016/j.pnpbp.2006.04.013_bib11) 1999; 45 Tolin (10.1016/j.pnpbp.2006.04.013_bib15) 2001; 39 Kuipers (10.1016/j.pnpbp.2006.04.013_bib5) 2005 Carlsson (10.1016/j.pnpbp.2006.04.013_bib3) 2001; 25 Lochner (10.1016/j.pnpbp.2006.04.013_bib7) 2003; 11 |
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| Snippet | Glutamatergic hyperactivity hypothesis in obsessive–compulsive disorder (OCD) has been proposed but not tested. Memantine is an uncompetitive
N-methyl-... Glutamatergic hyperactivity hypothesis in obsessive-compulsive disorder (OCD) has been proposed but not tested. Memantine is an uncompetitive... Glutamatergic hyperactivity hypothesis in obsessive-compulsive disorder (OCD) has been proposed but not tested. Memantine is an uncompetitive N-... |
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| SubjectTerms | Adult Adult and adolescent clinical studies Anxiety disorders. Neuroses Biological and medical sciences Drug Resistance Drug Therapy, Combination Excitatory Amino Acid Antagonists - therapeutic use Female Glutamatergic transmission Humans Male Medical sciences Memantine Memantine - therapeutic use Memory for actions Middle Aged Neuropharmacology Obsessive-Compulsive Disorder - drug therapy Obsessive-Compulsive Disorder - psychology Obsessive-compulsive disorders Obsessive–compulsive disorder Pharmacology. Drug treatments Psychiatric Status Rating Scales Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Serotonin Uptake Inhibitors - therapeutic use |
| Title | Memantine augmentation for refractory obsessive–compulsive disorder |
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