Reactive oxygen species and cancer: A complex interaction

Elevated levels of Reactive Oxygen Species (ROS), increased antioxidant ability and the maintenance of redox homeostasis can cumulatively contribute to tumor progression and metastasis. The sources and the role of ROS in a heterogeneous tumor microenvironment can vary at different stages of tumor: i...

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Bibliographic Details
Published in:	Cancer letters Vol. 452; pp. 132 - 143
Main Authors:	Saikolappan, Sankaralingam, Kumar, Binod, Shishodia, Gauri, Koul, Sweaty, Koul, Hari K.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 28.06.2019 Elsevier Limited
Subjects:	Androgens Antioxidants Apoptosis Breast cancer Cancer Cancer therapies Cell Hypoxia - physiology Deoxyribonucleic acid DNA DNA methylation Genotype & phenotype Homeostasis Humans Hypoxia Hypoxia Re-Oxygenation Metabolism Metabolites Metastases Metastasis Mitochondria Mitochondrial DNA Mutation NADPH Oxidase 4 - metabolism Neoplasms - pathology NF-E2-Related Factor 2 - metabolism Ovarian cancer Oxidation-Reduction Oxidative stress Prostate cancer Reactive oxygen species Reactive Oxygen Species - metabolism ROS Signal Transduction Solid tumors Transcription factors Tumor Microenvironment - physiology Tumorigenesis Tumors CDKN1A ALS PTEN RTK EGFR PCa ADT DHT CSC Nrf2 GATOR1 mROS GC JAK2 GSH FoxO APE1 VEGF IGF1 MAPK Hypoxia Re-Oxygenation EMT SIRT3 TRX1 AR STAT CXCL12 PDAC TEC ARE NOX ROS TGFβ TFAM ATM ATP CRPC Cancer ERK
ISSN:	0304-3835, 1872-7980, 1872-7980
Online Access:	Get full text
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