Reactive oxygen species and cancer: A complex interaction

Elevated levels of Reactive Oxygen Species (ROS), increased antioxidant ability and the maintenance of redox homeostasis can cumulatively contribute to tumor progression and metastasis. The sources and the role of ROS in a heterogeneous tumor microenvironment can vary at different stages of tumor: i...

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Veröffentlicht in:	Cancer letters Jg. 452; S. 132 - 143
Hauptverfasser:	Saikolappan, Sankaralingam, Kumar, Binod, Shishodia, Gauri, Koul, Sweaty, Koul, Hari K.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Ireland Elsevier B.V 28.06.2019 Elsevier Limited
Schlagworte:	Androgens Antioxidants Apoptosis Breast cancer Cancer Cancer therapies Cell Hypoxia - physiology Deoxyribonucleic acid DNA DNA methylation Genotype & phenotype Homeostasis Humans Hypoxia Hypoxia Re-Oxygenation Metabolism Metabolites Metastases Metastasis Mitochondria Mitochondrial DNA Mutation NADPH Oxidase 4 - metabolism Neoplasms - pathology NF-E2-Related Factor 2 - metabolism Ovarian cancer Oxidation-Reduction Oxidative stress Prostate cancer Reactive oxygen species Reactive Oxygen Species - metabolism ROS Signal Transduction Solid tumors Transcription factors Tumor Microenvironment - physiology Tumorigenesis Tumors CDKN1A ALS PTEN RTK EGFR PCa ADT DHT CSC Nrf2 GATOR1 mROS GC JAK2 GSH FoxO APE1 VEGF IGF1 MAPK Hypoxia Re-Oxygenation EMT SIRT3 TRX1 AR STAT CXCL12 PDAC TEC ARE NOX ROS TGFβ TFAM ATM ATP CRPC Cancer ERK
ISSN:	0304-3835, 1872-7980, 1872-7980
Online-Zugang:	Volltext
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Zusammenfassung:	Elevated levels of Reactive Oxygen Species (ROS), increased antioxidant ability and the maintenance of redox homeostasis can cumulatively contribute to tumor progression and metastasis. The sources and the role of ROS in a heterogeneous tumor microenvironment can vary at different stages of tumor: initiation, development, and progression, thus making it a complex subject. In this review, we have summarized the sources of ROS generation in cancer cells, its role in the tumor microenvironment, the possible functions of ROS and its important scavenger systems in tumor progression with special emphasis on solid tumors. •ROS is generated from Mitochondrial and Extra-mitochondrial sources and NOX4 appears to play a significant role in ROS generation in Solid tumors.•Tumor cells upregulate antioxidant defense and Redox balance influences tumor progression.•ROS is an integral component of Tumor microenvironment due to Hypoxia Re-oxygenation- and influences immunity.•ROS mediated cell signaling pathways offer attractive targets for therapeutic intervention.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	0304-3835 1872-7980 1872-7980
DOI:	10.1016/j.canlet.2019.03.020