Long non‐coding RNA PVT1: Emerging biomarker in digestive system cancer

The digestive system cancers are leading cause of cancer‐related death worldwide, and have high risks of morbidity and mortality. More and more long non‐coding RNAs (lncRNAs) have been studied to be abnormally expressed in cancers and play a key role in the process of digestive system tumour progres...

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Published in:	Cell proliferation Vol. 50; no. 6
Main Authors:	Zhou, Dan‐Dan, Liu, Xiu‐fen, Lu, Cheng‐wei, Pant, Om Prakash, Liu, Xiao‐dong
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.12.2017 John Wiley and Sons Inc
Subjects:	Animals Biomarkers Cancer Cell proliferation Cell Proliferation - genetics Colorectal carcinoma Digestive system Drug resistance Epithelial-Mesenchymal Transition - genetics Esophagus Gastric cancer Gene Expression Regulation, Neoplastic - genetics Hepatocellular carcinoma Humans Medical prognosis Mesenchyme Metastases Morbidity Myc protein Non-coding RNA Pancreatic cancer Pancreatic carcinoma Plasmacytoma Prognosis Review Ribonucleic acid Risk factors RNA RNA, Long Noncoding - genetics Stomach Neoplasms - genetics Survival Translocation Tumors
ISSN:	0960-7722, 1365-2184, 1365-2184
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Abstract	The digestive system cancers are leading cause of cancer‐related death worldwide, and have high risks of morbidity and mortality. More and more long non‐coding RNAs (lncRNAs) have been studied to be abnormally expressed in cancers and play a key role in the process of digestive system tumour progression. Plasmacytoma variant translocation 1 (PVT1) seems fairly novel. Since 1984, PVT1 was identified to be an activator of MYC in mice. Its role in human tumour initiation and progression has long been a subject of interest. The expression of PVT1 is elevated in digestive system cancers and correlates with poor prognosis. In this review, we illustrate the various functions of PVT1 during the different stages in the complex process of digestive system tumours (including oesophageal cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma and pancreatic cancer). The growing evidence shows the involvement of PVT1 in both proliferation and differentiation process in addition to its involvement in epithelial to mesenchymal transition (EMT). These findings lead us to conclude that PVT1 promotes proliferation, survival, invasion, metastasis and drug resistance in digestive system cancer cells. We will also discuss PVT1's potential in diagnosis and treatment target of digestive system cancer. There was a great probability PVT1 could be a novel biomarker in screening tumours, prognosis biomarkers and future targeted therapy to improve the survival rate in cancer patients.
AbstractList	The digestive system cancers are leading cause of cancer-related death worldwide, and have high risks of morbidity and mortality. More and more long non-coding RNAs (lncRNAs) have been studied to be abnormally expressed in cancers and play a key role in the process of digestive system tumour progression. Plasmacytoma variant translocation 1 (PVT1) seems fairly novel. Since 1984, PVT1 was identified to be an activator of MYC in mice. Its role in human tumour initiation and progression has long been a subject of interest. The expression of PVT1 is elevated in digestive system cancers and correlates with poor prognosis. In this review, we illustrate the various functions of PVT1 during the different stages in the complex process of digestive system tumours (including oesophageal cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma and pancreatic cancer). The growing evidence shows the involvement of PVT1 in both proliferation and differentiation process in addition to its involvement in epithelial to mesenchymal transition (EMT). These findings lead us to conclude that PVT1 promotes proliferation, survival, invasion, metastasis and drug resistance in digestive system cancer cells. We will also discuss PVT1's potential in diagnosis and treatment target of digestive system cancer. There was a great probability PVT1 could be a novel biomarker in screening tumours, prognosis biomarkers and future targeted therapy to improve the survival rate in cancer patients. The digestive system cancers are leading cause of cancer‐related death worldwide, and have high risks of morbidity and mortality. More and more long non‐coding RNA s (lnc RNA s) have been studied to be abnormally expressed in cancers and play a key role in the process of digestive system tumour progression. Plasmacytoma variant translocation 1 ( PVT 1) seems fairly novel. Since 1984, PVT 1 was identified to be an activator of MYC in mice. Its role in human tumour initiation and progression has long been a subject of interest. The expression of PVT 1 is elevated in digestive system cancers and correlates with poor prognosis. In this review, we illustrate the various functions of PVT 1 during the different stages in the complex process of digestive system tumours (including oesophageal cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma and pancreatic cancer). The growing evidence shows the involvement of PVT 1 in both proliferation and differentiation process in addition to its involvement in epithelial to mesenchymal transition ( EMT ). These findings lead us to conclude that PVT 1 promotes proliferation, survival, invasion, metastasis and drug resistance in digestive system cancer cells. We will also discuss PVT 1's potential in diagnosis and treatment target of digestive system cancer. There was a great probability PVT 1 could be a novel biomarker in screening tumours, prognosis biomarkers and future targeted therapy to improve the survival rate in cancer patients. The digestive system cancers are leading cause of cancer-related death worldwide, and have high risks of morbidity and mortality. More and more long non-coding RNAs (lncRNAs) have been studied to be abnormally expressed in cancers and play a key role in the process of digestive system tumour progression. Plasmacytoma variant translocation 1 (PVT1) seems fairly novel. Since 1984, PVT1 was identified to be an activator of MYC in mice. Its role in human tumour initiation and progression has long been a subject of interest. The expression of PVT1 is elevated in digestive system cancers and correlates with poor prognosis. In this review, we illustrate the various functions of PVT1 during the different stages in the complex process of digestive system tumours (including oesophageal cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma and pancreatic cancer). The growing evidence shows the involvement of PVT1 in both proliferation and differentiation process in addition to its involvement in epithelial to mesenchymal transition (EMT). These findings lead us to conclude that PVT1 promotes proliferation, survival, invasion, metastasis and drug resistance in digestive system cancer cells. We will also discuss PVT1's potential in diagnosis and treatment target of digestive system cancer. There was a great probability PVT1 could be a novel biomarker in screening tumours, prognosis biomarkers and future targeted therapy to improve the survival rate in cancer patients.The digestive system cancers are leading cause of cancer-related death worldwide, and have high risks of morbidity and mortality. More and more long non-coding RNAs (lncRNAs) have been studied to be abnormally expressed in cancers and play a key role in the process of digestive system tumour progression. Plasmacytoma variant translocation 1 (PVT1) seems fairly novel. Since 1984, PVT1 was identified to be an activator of MYC in mice. Its role in human tumour initiation and progression has long been a subject of interest. The expression of PVT1 is elevated in digestive system cancers and correlates with poor prognosis. In this review, we illustrate the various functions of PVT1 during the different stages in the complex process of digestive system tumours (including oesophageal cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma and pancreatic cancer). The growing evidence shows the involvement of PVT1 in both proliferation and differentiation process in addition to its involvement in epithelial to mesenchymal transition (EMT). These findings lead us to conclude that PVT1 promotes proliferation, survival, invasion, metastasis and drug resistance in digestive system cancer cells. We will also discuss PVT1's potential in diagnosis and treatment target of digestive system cancer. There was a great probability PVT1 could be a novel biomarker in screening tumours, prognosis biomarkers and future targeted therapy to improve the survival rate in cancer patients.
Author	Liu, Xiao‐dong Pant, Om Prakash Zhou, Dan‐Dan Liu, Xiu‐fen Lu, Cheng‐wei
AuthorAffiliation	2 Department of Radiology The First Hospital of Jilin University Changchun Jilin Province China 3 Department of Ophthalmology The First Hospital of Jilin University Changchun Jilin Province China 1 Key Laboratory of Radiobiology (Ministry of Health) School of Public Health Jilin University Changchun China
AuthorAffiliation_xml	– name: 2 Department of Radiology The First Hospital of Jilin University Changchun Jilin Province China – name: 1 Key Laboratory of Radiobiology (Ministry of Health) School of Public Health Jilin University Changchun China – name: 3 Department of Ophthalmology The First Hospital of Jilin University Changchun Jilin Province China
Author_xml	– sequence: 1 givenname: Dan‐Dan surname: Zhou fullname: Zhou, Dan‐Dan organization: The First Hospital of Jilin University – sequence: 2 givenname: Xiu‐fen surname: Liu fullname: Liu, Xiu‐fen organization: The First Hospital of Jilin University – sequence: 3 givenname: Cheng‐wei orcidid: 0000-0003-4335-4813 surname: Lu fullname: Lu, Cheng‐wei email: lcwchina800@sina.com organization: The First Hospital of Jilin University – sequence: 4 givenname: Om Prakash surname: Pant fullname: Pant, Om Prakash organization: The First Hospital of Jilin University – sequence: 5 givenname: Xiao‐dong surname: Liu fullname: Liu, Xiao‐dong email: doriszhoudan0928@sina.com organization: Jilin University
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Snippet	The digestive system cancers are leading cause of cancer‐related death worldwide, and have high risks of morbidity and mortality. More and more long non‐coding... The digestive system cancers are leading cause of cancer-related death worldwide, and have high risks of morbidity and mortality. More and more long non-coding...
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SubjectTerms	Animals Biomarkers Cancer Cell proliferation Cell Proliferation - genetics Colorectal carcinoma Digestive system Drug resistance Epithelial-Mesenchymal Transition - genetics Esophagus Gastric cancer Gene Expression Regulation, Neoplastic - genetics Hepatocellular carcinoma Humans Medical prognosis Mesenchyme Metastases Morbidity Myc protein Non-coding RNA Pancreatic cancer Pancreatic carcinoma Plasmacytoma Prognosis Review Ribonucleic acid Risk factors RNA RNA, Long Noncoding - genetics Stomach Neoplasms - genetics Survival Translocation Tumors
Title	Long non‐coding RNA PVT1: Emerging biomarker in digestive system cancer
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