Expression of programmed cell death protein 1 and T‐cell immunoglobulin‐ and mucin‐domain‐containing molecule‐3 on peripheral blood CD4+CD8+ double positive T cells in patients with chronic hepatitis C virus infection and in subjects who spontaneously cleared the virus

Chronic hepatitis C virus (HCV) infection is characterized by increased proportion of CD4+CD8+ double positive (DP) T cells, but their role in this infection is unclear. In chronic hepatitis C, immune responses to HCV become functionally exhausted, which manifests itself by increased expression of p...

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Bibliographic Details
Published in:	Journal of viral hepatitis Vol. 26; no. 8; pp. 942 - 950
Main Authors:	Caraballo Cortés, Kamila, Osuch, Sylwia, Perlejewski, Karol, Pawełczyk, Agnieszka, Kaźmierczak, Justyna, Janiak, Maciej, Jabłońska, Joanna, Nazzal, Khalil, Stelmaszczyk‐Emmel, Anna, Berak, Hanna, Bukowska‐Ośko, Iwona, Paciorek, Marcin, Laskus, Tomasz, Radkowski, Marek
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01.08.2019 John Wiley and Sons Inc
Subjects:	Adult Aged Apoptosis CD3 antigen CD4 antigen CD4-Positive T-Lymphocytes - metabolism CD8 antigen CD8-Positive T-Lymphocytes - metabolism Cell death Chronic infection DP T cells Epitopes Female Hepatitis Hepatitis A Virus Cellular Receptor 2 - metabolism Hepatitis C hepatitis C virus Hepatitis C, Chronic - blood Hepatitis C, Chronic - immunology Histocompatibility antigen HLA Humans Immunoglobulins Infections Interferon Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Lymphocytes Lymphocytes T Major histocompatibility complex Male Middle Aged Mucin Original PD‐1 Peripheral blood mononuclear cells Phenotypes Programmed Cell Death 1 Receptor - metabolism T-Lymphocyte Subsets - metabolism Tim‐3 hepatitis C virus DP T cells PD-1 Tim-3
ISSN:	1352-0504, 1365-2893, 1365-2893
Online Access:	Get full text
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