Denser brain capillary network with preserved pericytes in Alzheimer's disease

Pericytes are vascular mural cells that surround capillaries of the central nervous system (CNS). They are crucial for brain development and contribute to CNS homeostasis by regulating blood–brain barrier function and cerebral blood flow. It has been suggested that pericytes are lost in Alzheimer�...

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Vydané v:	Brain pathology (Zurich, Switzerland) Ročník 30; číslo 6; s. 1071 - 1086
Hlavní autori:	Fernandez‐Klett, Francisco, Brandt, Lasse, Fernández‐Zapata, Camila, Abuelnor, Basim, Middeldorp, Jinte, Sluijs, Jacqueline A., Curtis, Maurice, Faull, Richard, Harris, Laura W., Bahn, Sabine, Hol, Elly M., Priller, Josef
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland John Wiley & Sons, Inc 01.11.2020 John Wiley and Sons Inc
Predmet:	Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Alzheimer's disease (AD) Amyloid Amyloid beta-Peptides - metabolism angiogenesis Blood flow Blood-brain barrier Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology blood–brain barrier (BBB) Brain Capillaries Capillaries - metabolism Capillaries - pathology Central nervous system Cerebral blood flow Cerebrovascular Circulation - physiology clarity Cortex (frontal) Female Frontal Lobe - metabolism Frontal Lobe - pathology Homeostasis Humans Male Middle Aged Morphometry Neurodegenerative diseases Neuroimaging Pathology Peptide Fragments - metabolism Pericytes Pericytes - metabolism Pericytes - pathology Photons stereology two‐photon microscopy blood-brain barrier (BBB) clarity angiogenesis capillaries pericytes stereology Alzheimer's disease (AD) two-photon microscopy
ISSN:	1015-6305, 1750-3639, 1750-3639
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