Denser brain capillary network with preserved pericytes in Alzheimer's disease

Pericytes are vascular mural cells that surround capillaries of the central nervous system (CNS). They are crucial for brain development and contribute to CNS homeostasis by regulating blood–brain barrier function and cerebral blood flow. It has been suggested that pericytes are lost in Alzheimer�...

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Vydáno v:	Brain pathology (Zurich, Switzerland) Ročník 30; číslo 6; s. 1071 - 1086
Hlavní autoři:	Fernandez‐Klett, Francisco, Brandt, Lasse, Fernández‐Zapata, Camila, Abuelnor, Basim, Middeldorp, Jinte, Sluijs, Jacqueline A., Curtis, Maurice, Faull, Richard, Harris, Laura W., Bahn, Sabine, Hol, Elly M., Priller, Josef
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland John Wiley & Sons, Inc 01.11.2020 John Wiley and Sons Inc
Témata:	Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Alzheimer's disease (AD) Amyloid Amyloid beta-Peptides - metabolism angiogenesis Blood flow Blood-brain barrier Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology blood–brain barrier (BBB) Brain Capillaries Capillaries - metabolism Capillaries - pathology Central nervous system Cerebral blood flow Cerebrovascular Circulation - physiology clarity Cortex (frontal) Female Frontal Lobe - metabolism Frontal Lobe - pathology Homeostasis Humans Male Middle Aged Morphometry Neurodegenerative diseases Neuroimaging Pathology Peptide Fragments - metabolism Pericytes Pericytes - metabolism Pericytes - pathology Photons stereology two‐photon microscopy blood-brain barrier (BBB) clarity angiogenesis capillaries pericytes stereology Alzheimer's disease (AD) two-photon microscopy
ISSN:	1015-6305, 1750-3639, 1750-3639
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Popis
Shrnutí:	Pericytes are vascular mural cells that surround capillaries of the central nervous system (CNS). They are crucial for brain development and contribute to CNS homeostasis by regulating blood–brain barrier function and cerebral blood flow. It has been suggested that pericytes are lost in Alzheimer's disease (AD), implicating this cell type in disease pathology. Here, we have employed state‐of‐the‐art stereological morphometry techniques as well as tissue clearing and two‐photon imaging to assess the distribution of pericytes in two independent cohorts of AD (n = 16 and 13) and non‐demented controls (n = 16 and 4). Stereological quantification revealed increased capillary density with a normal pericyte population in the frontal cortex of AD brains, a region with early amyloid β deposition. Two‐photon analysis of cleared frontal cortex tissue confirmed the preservation of pericytes in AD cases. These results suggest that pericyte demise is not a general hallmark of AD pathology.
Bibliografie:	These authors contributed equally to this work ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1015-6305 1750-3639 1750-3639
DOI:	10.1111/bpa.12897