Denser brain capillary network with preserved pericytes in Alzheimer's disease

Pericytes are vascular mural cells that surround capillaries of the central nervous system (CNS). They are crucial for brain development and contribute to CNS homeostasis by regulating blood–brain barrier function and cerebral blood flow. It has been suggested that pericytes are lost in Alzheimer�...

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Bibliographic Details
Published in:Brain pathology (Zurich, Switzerland) Vol. 30; no. 6; pp. 1071 - 1086
Main Authors: Fernandez‐Klett, Francisco, Brandt, Lasse, Fernández‐Zapata, Camila, Abuelnor, Basim, Middeldorp, Jinte, Sluijs, Jacqueline A., Curtis, Maurice, Faull, Richard, Harris, Laura W., Bahn, Sabine, Hol, Elly M., Priller, Josef
Format: Journal Article
Language:English
Published: Switzerland John Wiley & Sons, Inc 01.11.2020
John Wiley and Sons Inc
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Alzheimer's disease (AD)
Amyloid
Amyloid beta-Peptides - metabolism
angiogenesis
Blood flow
Blood-brain barrier
Blood-Brain Barrier - metabolism
Blood-Brain Barrier - pathology
blood–brain barrier (BBB)
Brain
Capillaries
Capillaries - metabolism
Capillaries - pathology
Central nervous system
Cerebral blood flow
Cerebrovascular Circulation - physiology
clarity
Cortex (frontal)
Female
Frontal Lobe - metabolism
Frontal Lobe - pathology
Homeostasis
Humans
Male
Middle Aged
Morphometry
Neurodegenerative diseases
Neuroimaging
Pathology
Peptide Fragments - metabolism
Pericytes
Pericytes - metabolism
Pericytes - pathology
Photons
stereology
two‐photon microscopy
blood-brain barrier (BBB)
clarity
angiogenesis
capillaries
pericytes
stereology
Alzheimer's disease (AD)
two-photon microscopy
ISSN:1015-6305, 1750-3639, 1750-3639
Online Access:Get full text
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Summary:Pericytes are vascular mural cells that surround capillaries of the central nervous system (CNS). They are crucial for brain development and contribute to CNS homeostasis by regulating blood–brain barrier function and cerebral blood flow. It has been suggested that pericytes are lost in Alzheimer's disease (AD), implicating this cell type in disease pathology. Here, we have employed state‐of‐the‐art stereological morphometry techniques as well as tissue clearing and two‐photon imaging to assess the distribution of pericytes in two independent cohorts of AD (n = 16 and 13) and non‐demented controls (n = 16 and 4). Stereological quantification revealed increased capillary density with a normal pericyte population in the frontal cortex of AD brains, a region with early amyloid β deposition. Two‐photon analysis of cleared frontal cortex tissue confirmed the preservation of pericytes in AD cases. These results suggest that pericyte demise is not a general hallmark of AD pathology.
Bibliography:These authors contributed equally to this work
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ISSN:1015-6305
1750-3639
1750-3639
DOI:10.1111/bpa.12897