Self‐rated health scores predict mortality among people with type 2 diabetes differently across three different country groupings: findings from the ADVANCE and ADVANCE‐ON trials

Aims To explore whether there is a different strength of association between self‐rated health and all‐cause mortality in people with type 2 diabetes across three country groupings: nine countries grouped together as 'established market economies'; Asia; and Eastern Europe. Methods The ADV...

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Vydáno v:Diabetic medicine Ročník 37; číslo 8; s. 1379 - 1385
Hlavní autoři: Hua, X., Lung, T. W. C., Woodward, M., Salomon, J. A., Hamet, P., Harrap, S. B., Mancia, G., Poulter, N., Chalmers, J., Clarke, P. M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Wiley Subscription Services, Inc 01.08.2020
John Wiley and Sons Inc
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ISSN:0742-3071, 1464-5491, 1464-5491
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Abstract Aims To explore whether there is a different strength of association between self‐rated health and all‐cause mortality in people with type 2 diabetes across three country groupings: nine countries grouped together as 'established market economies'; Asia; and Eastern Europe. Methods The ADVANCE trial and its post‐trial follow‐up were used in this study, which included 11 140 people with type 2 diabetes from 20 countries, with a median follow‐up of 9.9 years. Self‐rated health was reported on a 0–100 visual analogue scale. Cox proportional hazard models were fitted to estimate the relationship between the visual analogue scale score and all‐cause mortality, controlling for a range of demographic and clinical risk factors. Interaction terms were used to assess whether the association between the visual analogue scale score and mortality varied across country groupings. Results The visual analogue scale score had different strengths of association with mortality in the three country groupings. A 10‐point increase in visual analogue scale score was associated with a 15% (95% CI 12–18) lower mortality hazard in the established market economies, a 25% (95% CI 21–28) lower hazard in Asia, and an 8% (95% CI 3–13) lower hazard in Eastern Europe. Conclusions Self‐rated health appears to predict 10‐year all‐cause mortality for people with type 2 diabetes worldwide, but this relationship varies across groups of countries. What's new? Self‐rated health is an independent predictor of mortality in people with diabetes. The visual analogue scale (VAS) score has a stronger association with mortality in Asia and a weaker association in Eastern Europe than in the 'established market economies' included in our study among people with type 2 diabetes. People with type 2 diabetes in different countries reporting the same VAS score can face different mortality risks. The VAS score can be a useful global health measure in clinical practice for people with type 2 diabetes, but adjustment would be required before it can be directly compared across countries and regions.
AbstractList Self‐rated health is an independent predictor of mortality in people with diabetes.The visual analogue scale (VAS) score has a stronger association with mortality in Asia and a weaker association in Eastern Europe than in the 'established market economies' included in our study among people with type 2 diabetes.People with type 2 diabetes in different countries reporting the same VAS score can face different mortality risks.The VAS score can be a useful global health measure in clinical practice for people with type 2 diabetes, but adjustment would be required before it can be directly compared across countries and regions.
To explore whether there is a different strength of association between self-rated health and all-cause mortality in people with type 2 diabetes across three country groupings: nine countries grouped together as 'established market economies'; Asia; and Eastern Europe. The ADVANCE trial and its post-trial follow-up were used in this study, which included 11 140 people with type 2 diabetes from 20 countries, with a median follow-up of 9.9 years. Self-rated health was reported on a 0-100 visual analogue scale. Cox proportional hazard models were fitted to estimate the relationship between the visual analogue scale score and all-cause mortality, controlling for a range of demographic and clinical risk factors. Interaction terms were used to assess whether the association between the visual analogue scale score and mortality varied across country groupings. The visual analogue scale score had different strengths of association with mortality in the three country groupings. A 10-point increase in visual analogue scale score was associated with a 15% (95% CI 12-18) lower mortality hazard in the established market economies, a 25% (95% CI 21-28) lower hazard in Asia, and an 8% (95% CI 3-13) lower hazard in Eastern Europe. Self-rated health appears to predict 10-year all-cause mortality for people with type 2 diabetes worldwide, but this relationship varies across groups of countries.
AimsTo explore whether there is a different strength of association between self‐rated health and all‐cause mortality in people with type 2 diabetes across three country groupings: nine countries grouped together as 'established market economies'; Asia; and Eastern Europe.MethodsThe ADVANCE trial and its post‐trial follow‐up were used in this study, which included 11 140 people with type 2 diabetes from 20 countries, with a median follow‐up of 9.9 years. Self‐rated health was reported on a 0–100 visual analogue scale. Cox proportional hazard models were fitted to estimate the relationship between the visual analogue scale score and all‐cause mortality, controlling for a range of demographic and clinical risk factors. Interaction terms were used to assess whether the association between the visual analogue scale score and mortality varied across country groupings.ResultsThe visual analogue scale score had different strengths of association with mortality in the three country groupings. A 10‐point increase in visual analogue scale score was associated with a 15% (95% CI 12–18) lower mortality hazard in the established market economies, a 25% (95% CI 21–28) lower hazard in Asia, and an 8% (95% CI 3–13) lower hazard in Eastern Europe.ConclusionsSelf‐rated health appears to predict 10‐year all‐cause mortality for people with type 2 diabetes worldwide, but this relationship varies across groups of countries.
Aims To explore whether there is a different strength of association between self‐rated health and all‐cause mortality in people with type 2 diabetes across three country groupings: nine countries grouped together as 'established market economies'; Asia; and Eastern Europe. Methods The ADVANCE trial and its post‐trial follow‐up were used in this study, which included 11 140 people with type 2 diabetes from 20 countries, with a median follow‐up of 9.9 years. Self‐rated health was reported on a 0–100 visual analogue scale. Cox proportional hazard models were fitted to estimate the relationship between the visual analogue scale score and all‐cause mortality, controlling for a range of demographic and clinical risk factors. Interaction terms were used to assess whether the association between the visual analogue scale score and mortality varied across country groupings. Results The visual analogue scale score had different strengths of association with mortality in the three country groupings. A 10‐point increase in visual analogue scale score was associated with a 15% (95% CI 12–18) lower mortality hazard in the established market economies, a 25% (95% CI 21–28) lower hazard in Asia, and an 8% (95% CI 3–13) lower hazard in Eastern Europe. Conclusions Self‐rated health appears to predict 10‐year all‐cause mortality for people with type 2 diabetes worldwide, but this relationship varies across groups of countries. What's new? Self‐rated health is an independent predictor of mortality in people with diabetes. The visual analogue scale (VAS) score has a stronger association with mortality in Asia and a weaker association in Eastern Europe than in the 'established market economies' included in our study among people with type 2 diabetes. People with type 2 diabetes in different countries reporting the same VAS score can face different mortality risks. The VAS score can be a useful global health measure in clinical practice for people with type 2 diabetes, but adjustment would be required before it can be directly compared across countries and regions.
Self‐rated health is an independent predictor of mortality in people with diabetes. The visual analogue scale (VAS) score has a stronger association with mortality in Asia and a weaker association in Eastern Europe than in the 'established market economies' included in our study among people with type 2 diabetes. People with type 2 diabetes in different countries reporting the same VAS score can face different mortality risks. The VAS score can be a useful global health measure in clinical practice for people with type 2 diabetes, but adjustment would be required before it can be directly compared across countries and regions.
To explore whether there is a different strength of association between self-rated health and all-cause mortality in people with type 2 diabetes across three country groupings: nine countries grouped together as 'established market economies'; Asia; and Eastern Europe.AIMSTo explore whether there is a different strength of association between self-rated health and all-cause mortality in people with type 2 diabetes across three country groupings: nine countries grouped together as 'established market economies'; Asia; and Eastern Europe.The ADVANCE trial and its post-trial follow-up were used in this study, which included 11 140 people with type 2 diabetes from 20 countries, with a median follow-up of 9.9 years. Self-rated health was reported on a 0-100 visual analogue scale. Cox proportional hazard models were fitted to estimate the relationship between the visual analogue scale score and all-cause mortality, controlling for a range of demographic and clinical risk factors. Interaction terms were used to assess whether the association between the visual analogue scale score and mortality varied across country groupings.METHODSThe ADVANCE trial and its post-trial follow-up were used in this study, which included 11 140 people with type 2 diabetes from 20 countries, with a median follow-up of 9.9 years. Self-rated health was reported on a 0-100 visual analogue scale. Cox proportional hazard models were fitted to estimate the relationship between the visual analogue scale score and all-cause mortality, controlling for a range of demographic and clinical risk factors. Interaction terms were used to assess whether the association between the visual analogue scale score and mortality varied across country groupings.The visual analogue scale score had different strengths of association with mortality in the three country groupings. A 10-point increase in visual analogue scale score was associated with a 15% (95% CI 12-18) lower mortality hazard in the established market economies, a 25% (95% CI 21-28) lower hazard in Asia, and an 8% (95% CI 3-13) lower hazard in Eastern Europe.RESULTSThe visual analogue scale score had different strengths of association with mortality in the three country groupings. A 10-point increase in visual analogue scale score was associated with a 15% (95% CI 12-18) lower mortality hazard in the established market economies, a 25% (95% CI 21-28) lower hazard in Asia, and an 8% (95% CI 3-13) lower hazard in Eastern Europe.Self-rated health appears to predict 10-year all-cause mortality for people with type 2 diabetes worldwide, but this relationship varies across groups of countries.CONCLUSIONSSelf-rated health appears to predict 10-year all-cause mortality for people with type 2 diabetes worldwide, but this relationship varies across groups of countries.
Author Chalmers, J.
Poulter, N.
Clarke, P. M.
Salomon, J. A.
Mancia, G.
Woodward, M.
Hamet, P.
Hua, X.
Harrap, S. B.
Lung, T. W. C.
AuthorAffiliation 3 George Institute for Global Health UNSW Sydney Sydney NSW Australia
4 School of Public Health Faculty of Medicine and Health University of Sydney Sydney NSW Australia
7 Department of Medicine Stanford Medical School Stanford CA USA
5 George Institute for Global Health University of Oxford Oxford UK
8 Centre de Recherche Centre Hospitalier de l'Université de Montréal Montréal QC Canada
12 Imperial Clinical Trials Unit School of Public Health Imperial College London London UK
11 University of Milano‐Bicocca Milan Italy
9 Department of Medicine University of Montréal Montréal QC Canada
2 Nuffield Department of Population Health University of Oxford Oxford UK
10 Department of Physiology University of Melbourne Melbourne VIC Australia
6 Department of Epidemiology Johns Hopkins University Baltimore MD USA
1 School of Population and Global Health University of Melbourne Melbourne VIC Australia
AuthorAffiliation_xml – name: 1 School of Population and Global Health University of Melbourne Melbourne VIC Australia
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Copyright 2020 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK
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Snippet Aims To explore whether there is a different strength of association between self‐rated health and all‐cause mortality in people with type 2 diabetes across...
Self‐rated health is an independent predictor of mortality in people with diabetes. The visual analogue scale (VAS) score has a stronger association with...
To explore whether there is a different strength of association between self-rated health and all-cause mortality in people with type 2 diabetes across three...
AimsTo explore whether there is a different strength of association between self‐rated health and all‐cause mortality in people with type 2 diabetes across...
Self‐rated health is an independent predictor of mortality in people with diabetes.The visual analogue scale (VAS) score has a stronger association with...
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SubjectTerms Clinical trials
Diabetes
Diabetes mellitus (non-insulin dependent)
Market economies
Mortality
Research: Epidemiology
Risk factors
Title Self‐rated health scores predict mortality among people with type 2 diabetes differently across three different country groupings: findings from the ADVANCE and ADVANCE‐ON trials
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fdme.14237
https://www.ncbi.nlm.nih.gov/pubmed/31967344
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https://pubmed.ncbi.nlm.nih.gov/PMC7496988
Volume 37
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