CAR T‐cell therapy for pancreatic cancer

Chimeric antigen receptor (CAR) T‐cell therapy utilizes genetic engineering to redirect a patient's own T cells to target cancer cells. The remarkable results in hematological malignancies prompted investigating this approach in solid tumors such as pancreatic cancer. The complex tumor microenv...

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Published in:Journal of surgical oncology Vol. 116; no. 1; pp. 63 - 74
Main Authors: DeSelm, Carl J., Tano, Zachary E., Varghese, Anna M., Adusumilli, Prasad S.
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01.07.2017
Subjects:
adoptive cell therapy
Antigens, Neoplasm - immunology
Cancer surgery
CAR T cells
Carcinoembryonic Antigen - immunology
CD24 Antigen - immunology
checkpoint blockade
chimeric antigen receptor
Clinical Trials as Topic
GPI-Linked Proteins - immunology
Humans
immunotherapy
Immunotherapy, Adoptive
Mesothelin
Mucin-1 - immunology
Neoplasm Proteins - immunology
Pancreatic cancer
Pancreatic Neoplasms - immunology
Pancreatic Neoplasms - therapy
Receptor, ErbB-2 - immunology
Receptors, Antigen, T-Cell
Receptors, Natural Killer Cell - immunology
Stromal Cells - immunology
T-Lymphocytes - immunology
T-Lymphocytes - transplantation
Transplantation Conditioning
checkpoint blockade
chimeric antigen receptor
CAR T cells
adoptive cell therapy
immunotherapy
ISSN:0022-4790, 1096-9098, 1096-9098
Online Access:Get full text
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Abstract Chimeric antigen receptor (CAR) T‐cell therapy utilizes genetic engineering to redirect a patient's own T cells to target cancer cells. The remarkable results in hematological malignancies prompted investigating this approach in solid tumors such as pancreatic cancer. The complex tumor microenvironment, stromal hindrance in limiting immune response, and expression of checkpoint blockade on T cells pose hurdles. Herein, we summarize the opportunities, challenges, and state of knowledge in targeting pancreatic cancer with CAR T‐cell therapy.
AbstractList Chimeric antigen receptor (CAR) T-cell therapy utilizes genetic engineering to redirect a patient's own T cells to target cancer cells. The remarkable results in hematological malignancies prompted investigating this approach in solid tumors such as pancreatic cancer. The complex tumor microenvironment, stromal hindrance in limiting immune response, and expression of checkpoint blockade on T cells pose hurdles. Herein, we summarize the opportunities, challenges, and state of knowledge in targeting pancreatic cancer with CAR T-cell therapy.
Chimeric antigen receptor (CAR) T-cell therapy utilizes genetic engineering to redirect a patient's own T cells to target cancer cells. The remarkable results in hematological malignancies prompted investigating this approach in solid tumors such as pancreatic cancer. The complex tumor microenvironment, stromal hindrance in limiting immune response, and expression of checkpoint blockade on T cells pose hurdles. Herein, we summarize the opportunities, challenges, and state of knowledge in targeting pancreatic cancer with CAR T-cell therapy.Chimeric antigen receptor (CAR) T-cell therapy utilizes genetic engineering to redirect a patient's own T cells to target cancer cells. The remarkable results in hematological malignancies prompted investigating this approach in solid tumors such as pancreatic cancer. The complex tumor microenvironment, stromal hindrance in limiting immune response, and expression of checkpoint blockade on T cells pose hurdles. Herein, we summarize the opportunities, challenges, and state of knowledge in targeting pancreatic cancer with CAR T-cell therapy.
Chimeric antigen receptor (CAR) T-cell therapy utilizes genetic engineering to redirect a patient’s own T cells to target cancer cells. The remarkable results in hematological malignancies prompted investigating this approach in solid tumors such as pancreatic cancer. The complex tumor microenvironment, stromal hindrance in limiting immune response, and expression of checkpoint blockade on T cells poses hurdles. Herein, we summarize the opportunities, challenges, and state of knowledge in targeting pancreatic cancer with CAR T-cell therapy.
Author Tano, Zachary E.
Varghese, Anna M.
Adusumilli, Prasad S.
DeSelm, Carl J.
AuthorAffiliation 1 Center for Cell Engineering, Memorial Sloan Kettering Cancer Center
2 Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
3 Gastrointestinal Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center
AuthorAffiliation_xml – name: 1 Center for Cell Engineering, Memorial Sloan Kettering Cancer Center
– name: 2 Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
– name: 3 Gastrointestinal Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center
Author_xml – sequence: 1
  givenname: Carl J.
  surname: DeSelm
  fullname: DeSelm, Carl J.
  organization: Memorial Sloan Kettering Cancer Center
– sequence: 2
  givenname: Zachary E.
  surname: Tano
  fullname: Tano, Zachary E.
  organization: Memorial Sloan Kettering Cancer Center
– sequence: 3
  givenname: Anna M.
  surname: Varghese
  fullname: Varghese, Anna M.
  organization: Memorial Sloan Kettering Cancer Center
– sequence: 4
  givenname: Prasad S.
  orcidid: 0000-0002-1699-2046
  surname: Adusumilli
  fullname: Adusumilli, Prasad S.
  email: adusumip@mskcc.org
  organization: Memorial Sloan Kettering Cancer Center
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28346697$$D View this record in MEDLINE/PubMed
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Keywords checkpoint blockade
chimeric antigen receptor
CAR T cells
adoptive cell therapy
immunotherapy
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1988; 90
2016; 17
2001; 24
2007; 13
2012; 32
2007; 14
2011; 253
2011; 9
2015; 350
2016; 6
2004; 279
2016; 3
2005; 124
2013; 73
2005; 8
2015; 112
2009; 100
2013; 210
2008; 44
2016; 29
2016; 8
2005; 11
2012; 119
2009; 106
2013; 29
2017; 6
1989; 86
2013; 21
2002; 196
2015; 33
2016; 76
1986; 39
2011; 13
2008; 6
2011; 17
2013; 19
2015; 294
2006; 60
1998; 59
2009; 58
2014; 5
2011; 208
2014; 4
2014; 3
2014; 2
2005; 31
2016; 111
2009; 284
2014; 9
2009; 206
1996; 2
2014; 6
2011; 167
2012; 143
2006; 12
2010
2010; 403
2002; 298
2011; 40
2008; 14
2001; 409
2008; 99
2016; 126
2005; 49
2004; 91
2015; 8
2015; 7
2014; 105
2009; 35
2015; 28
2013; 36
2002; 20
1988; 9
2013; 32
2013; 31
2015; 21
2016
2009; 4
2014; 74
2008; 178
2012; 7
1996; 42
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Snippet Chimeric antigen receptor (CAR) T‐cell therapy utilizes genetic engineering to redirect a patient's own T cells to target cancer cells. The remarkable results...
Chimeric antigen receptor (CAR) T-cell therapy utilizes genetic engineering to redirect a patient's own T cells to target cancer cells. The remarkable results...
Chimeric antigen receptor (CAR) T-cell therapy utilizes genetic engineering to redirect a patient’s own T cells to target cancer cells. The remarkable results...
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wiley
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StartPage 63
SubjectTerms adoptive cell therapy
Antigens, Neoplasm - immunology
Cancer surgery
CAR T cells
Carcinoembryonic Antigen - immunology
CD24 Antigen - immunology
checkpoint blockade
chimeric antigen receptor
Clinical Trials as Topic
GPI-Linked Proteins - immunology
Humans
immunotherapy
Immunotherapy, Adoptive
Mesothelin
Mucin-1 - immunology
Neoplasm Proteins - immunology
Pancreatic cancer
Pancreatic Neoplasms - immunology
Pancreatic Neoplasms - therapy
Receptor, ErbB-2 - immunology
Receptors, Antigen, T-Cell
Receptors, Natural Killer Cell - immunology
Stromal Cells - immunology
T-Lymphocytes - immunology
T-Lymphocytes - transplantation
Transplantation Conditioning
Title CAR T‐cell therapy for pancreatic cancer
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjso.24627
https://www.ncbi.nlm.nih.gov/pubmed/28346697
https://www.proquest.com/docview/1914572600
https://www.proquest.com/docview/1881774076
https://pubmed.ncbi.nlm.nih.gov/PMC5491361
Volume 116
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