Placenta microstructure and microcirculation imaging with diffusion MRI

Purpose To assess which microstructural models best explain the diffusion‐weighted MRI signal in the human placenta. Methods The placentas of nine healthy pregnant subjects were scanned with a multishell, multidirectional diffusion protocol at 3T. A range of multicompartment biophysical models were...

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Vydané v:Magnetic resonance in medicine Ročník 80; číslo 2; s. 756 - 766
Hlavní autori: Slator, Paddy J., Hutter, Jana, McCabe, Laura, Gomes, Ana Dos Santos, Price, Anthony N., Panagiotaki, Eleftheria, Rutherford, Mary A., Hajnal, Joseph V., Alexander, Daniel C.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Wiley Subscription Services, Inc 01.08.2018
John Wiley and Sons Inc
Predmet:
Anisotropy
Bayes Theorem
Bayesian analysis
Bayesian information criterion
Criteria
Diffusion
Diffusion coefficient
Diffusion Magnetic Resonance Imaging - methods
diffusion MRI
Female
Fetuses
Full Papers—Computer Processing and Modeling
Humans
Image Processing, Computer-Assisted - methods
Information theory
intravoxel incoherent motion
Magnetic resonance imaging
Mathematical models
Medicine
Microcirculation - physiology
Microstructure
Microvasculature
model selection
Orientation effects
Parameter sensitivity
Placenta
Placenta - blood supply
Placenta - diagnostic imaging
Pregnancy
diffusion MRI
model selection
placenta
microstructure
Bayesian information criterion
intravoxel incoherent motion
ISSN:0740-3194, 1522-2594, 1522-2594
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Shrnutí:Purpose To assess which microstructural models best explain the diffusion‐weighted MRI signal in the human placenta. Methods The placentas of nine healthy pregnant subjects were scanned with a multishell, multidirectional diffusion protocol at 3T. A range of multicompartment biophysical models were fit to the data, and ranked using the Bayesian information criterion. Results Anisotropic extensions to the intravoxel incoherent motion model, which consider the effect of coherent orientation in both microvascular structure and tissue microstructure, consistently had the lowest Bayesian information criterion values. Model parameter maps and model selection results were consistent with the physiology of the placenta and surrounding tissue. Conclusion Anisotropic intravoxel incoherent motion models explain the placental diffusion signal better than apparent diffusion coefficient, intravoxel incoherent motion, and diffusion tensor models, in information theoretic terms, when using this protocol. Future work will aim to determine if model‐derived parameters are sensitive to placental pathologies associated with disorders, such as fetal growth restriction and early‐onset pre‐eclampsia. Magn Reson Med 80:756–766, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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ISSN:0740-3194
1522-2594
1522-2594
DOI:10.1002/mrm.27036