Concise Review: Modeling Neurodegenerative Diseases with Human Pluripotent Stem Cell‐Derived Microglia

Inflammation of the brain and the consequential immunological responses play pivotal roles in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and frontotemporal dementia (FTD). Microglia, the resident macrophage cells of the brain...

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Bibliographic Details
Published in:	Stem cells (Dayton, Ohio) Vol. 37; no. 6; pp. 724 - 730
Main Authors:	Haenseler, Walther, Rajendran, Lawrence
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01.06.2019 Oxford University Press
Subjects:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - therapy Alzheimer's disease Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Amyotrophic Lateral Sclerosis - therapy Brain Cell lines Cell- and Tissue-Based Therapy - methods Coculture Techniques Dementia disorders Disease control Drug screening Embryonic Stem Cells/Induced Pluripotent Stem Cells Experimental models Frontotemporal dementia Frontotemporal Dementia - genetics Frontotemporal Dementia - metabolism Frontotemporal Dementia - pathology Frontotemporal Dementia - therapy Gene Knockout Techniques Genetic Engineering - methods Glia High-Throughput Screening Assays Humans Immunology Induced pluripotent stem cells Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - pathology Inflammation Macrophages Microglia Microglia - drug effects Microglia - metabolism Microglia - pathology Modelling Models, Biological Monoculture Movement disorders Myeloid cells Neurodegeneration Neurodegenerative diseases Neuroimmune Neurological diseases Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotective Agents - therapeutic use Nootropic Agents - therapeutic use Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson Disease - therapy Parkinson's disease Phenotyping Pluripotency Stem cells Synapses Yolk sac cell Myeloid cells Glia Yolk sac cell Induced pluripotent stem cells Experimental models Neuroimmune
ISSN:	1066-5099, 1549-4918, 1549-4918
Online Access:	Get full text
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