Predicting the spectrum of TCR repertoire sharing with a data‐driven model of recombination

Summary Despite the extreme diversity of T‐cell repertoires, many identical T‐cell receptor (TCR) sequences are found in a large number of individual mice and humans. These widely shared sequences, often referred to as “public,” have been suggested to be over‐represented due to their potential immun...

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Bibliographic Details
Published in:	Immunological reviews Vol. 284; no. 1; pp. 167 - 179
Main Authors:	Elhanati, Yuval, Sethna, Zachary, Callan, Curtis G., Mora, Thierry, Walczak, Aleksandra M.
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01.07.2018 John Wiley and Sons Inc
Subjects:	Algorithms Animals Classifiers Humans inference Invited Review Invited Reviews Mathematical models Mice Probabilistic inference probability of generation public sequences Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Sequences Statistical analysis T cell receptors T-Lymphocytes - immunology TCR repertoires TCR sharing Thymus V(D)J recombination V(D)J Recombination - genetics V(D)J Recombination - immunology probability of generation TCR repertoires TCR sharing public sequences inference
ISSN:	0105-2896, 1600-065X, 1600-065X
Online Access:	Get full text
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