Predicting the spectrum of TCR repertoire sharing with a data‐driven model of recombination

Summary Despite the extreme diversity of T‐cell repertoires, many identical T‐cell receptor (TCR) sequences are found in a large number of individual mice and humans. These widely shared sequences, often referred to as “public,” have been suggested to be over‐represented due to their potential immun...

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Veröffentlicht in:Immunological reviews Jg. 284; H. 1; S. 167 - 179
Hauptverfasser: Elhanati, Yuval, Sethna, Zachary, Callan, Curtis G., Mora, Thierry, Walczak, Aleksandra M.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Wiley Subscription Services, Inc 01.07.2018
John Wiley and Sons Inc
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ISSN:0105-2896, 1600-065X, 1600-065X
Online-Zugang:Volltext
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