Predicting the spectrum of TCR repertoire sharing with a data‐driven model of recombination

Summary Despite the extreme diversity of T‐cell repertoires, many identical T‐cell receptor (TCR) sequences are found in a large number of individual mice and humans. These widely shared sequences, often referred to as “public,” have been suggested to be over‐represented due to their potential immun...

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Vydáno v:	Immunological reviews Ročník 284; číslo 1; s. 167 - 179
Hlavní autoři:	Elhanati, Yuval, Sethna, Zachary, Callan, Curtis G., Mora, Thierry, Walczak, Aleksandra M.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Wiley Subscription Services, Inc 01.07.2018 John Wiley and Sons Inc
Témata:	Algorithms Animals Classifiers Humans inference Invited Review Invited Reviews Mathematical models Mice Probabilistic inference probability of generation public sequences Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Sequences Statistical analysis T cell receptors T-Lymphocytes - immunology TCR repertoires TCR sharing Thymus V(D)J recombination V(D)J Recombination - genetics V(D)J Recombination - immunology probability of generation TCR repertoires TCR sharing public sequences inference
ISSN:	0105-2896, 1600-065X, 1600-065X
On-line přístup:	Získat plný text
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