MarCell™ software for modeling bone marrow radiation cell kinetics

Differential equations were used to model cellular injury, repair, and compensatory proliferation in the irradiated bone marrow. Recently, that model was implemented as MarCell™, a user-friendly MS-DOS computer program that allows users from a variety of technical disciplines to evaluate complex rad...

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Bibliographic Details
Published in:Medical physics (Lancaster) Vol. 24; no. 11; pp. 1793 - 1796
Main Authors: Hasan, J. S., Jones, T. D., Morris, M. D.
Format: Journal Article
Language:English
Published: United States American Association of Physicists in Medicine 01.11.1997
Subjects:
87.50.01
87.51.04
Animals
biological effects of ionising radiation
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
biology computing
Biophysical Phenomena
Biophysical techniques (research methods)
Biophysics
bone
BONE MARROW CELLS
Bone Marrow Cells - cytology
Bone Marrow Cells - radiation effects
Cancer
Cell Division - radiation effects
Cell growth
Cell processes
CELL PROLIFERATION
Cell Survival - radiation effects
cellular effects of radiation
CFU
Colony-Forming Units Assay
complete computer programs
Computer modeling
Computer modeling and simulation
COMPUTER PROGRAM DOCUMENTATION
Computer software
Differential equations
digital simulation
Dogs
Dose-Response Relationship, Radiation
Dosimetry
Effects of ionizing radiation on biological systems
General theory and mathematical aspects
Humans
Ionizing radiation
Kinetics
LEUKEMIA
Leukemia - pathology
Leukemia - radiotherapy
Lymphoma - pathology
Lymphoma - radiotherapy
Mice
Models, Biological
Radiation treatment
Radiotherapy sources
Rats
RISK ASSESSMENT
Software
Tumor Stem Cell Assay
X‐rays
BONE MARROW CELLS
COMPUTER PROGRAM DOCUMENTATION
BIOLOGICAL RECOVERY
CFU
RISK ASSESSMENT
BIOLOGICAL RADIATION EFFECTS
CELL PROLIFERATION
LEUKEMIA
87.50.01
87.51.04
ISSN:0094-2405, 2473-4209
Online Access:Get full text
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Summary:Differential equations were used to model cellular injury, repair, and compensatory proliferation in the irradiated bone marrow. Recently, that model was implemented as MarCell™, a user-friendly MS-DOS computer program that allows users from a variety of technical disciplines to evaluate complex radiation exposure. The software allows menu selections for different sources of ionizing radiation. Choices for cell lineages include progenitor, stroma, and malignant, and the available species include mouse, rat, dog, sheep, swine, burro, and man. An attractive feature is that any protracted irradiation can be compared with an equivalent prompt dose (EPD) in terms of cell kinetics for either the source used or for a reference such as 250 kVp x rays or 60 Co . EPD is used to mean a dose rate for which no meaningful biological recovery occurs during the period of irradiation. For human as species, output from MarCell™ includes: risk of 30-day mortality; risk of whole-body cancer and leukemia based either on radiation-induced cytopenia or compensatory cell proliferation; cell survival and repopulation plots as functions of time or dose; and 4-week recovery following treatment.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0094-2405
2473-4209
DOI:10.1118/1.597945