CYP3A5 genotype and its impact on vincristine pharmacokinetics and development of neuropathy in Kenyan children with cancer

Background Vincristine (VCR) is a critical part of treatment in pediatric malignancies and is associated with dose‐dependent peripheral neuropathy (vincristine‐induced peripheral neuropathy [VIPN]). Our previous findings show VCR metabolism is regulated by the CYP3A5 gene. Individuals who are low CY...

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Veröffentlicht in:	Pediatric blood & cancer Jg. 65; H. 3
Hauptverfasser:	Skiles, Jodi L., Chiang, ChienWei, Li, Claire H., Martin, Steve, Smith, Ellen L., Olbara, Gilbert, Jones, David R., Vik, Terry A., Mostert, Saskia, Abbink, Floor, Kaspers, Gertjan J., Li, Lang, Njuguna, Festus, Sajdyk, Tammy J., Renbarger, Jamie L.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Wiley Subscription Services, Inc 01.03.2018
Schlagworte:	Cancer Children CYP3A protein Drug resistance Genetic factors Genotype & phenotype Genotyping Hematology MDR1 protein Multidrug resistance neuropathy Oncology P-Glycoprotein Pediatrics Peripheral neuropathy Pharmacokinetics Tau protein Vincristine neuropathy cancer vincristine genotyping pediatrics
ISSN:	1545-5009, 1545-5017, 1545-5017
Online-Zugang:	Volltext
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