OSCP subunit of mitochondrial ATP synthase: role in regulation of enzyme function and of its transition to a pore

The permeability transition pore (PTP) is a latent, high‐conductance channel of the inner mitochondrial membrane. When activated, it plays a key role in cell death and therefore in several diseases. The investigation of the PTP took an unexpected turn after the discovery that cyclophilin D (the targ...

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Vydáno v:	British journal of pharmacology Ročník 176; číslo 22; s. 4247 - 4257
Hlavní autoři:	Giorgio, Valentina, Fogolari, Federico, Lippe, Giovanna, Bernardi, Paolo
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Blackwell Publishing Ltd 01.11.2019 John Wiley and Sons Inc
Témata:	Animals ATP synthase Calcium channels Calcium conductance Cell death Cyclosporin A Enzymes Humans Membrane permeability Mitochondrial Membrane Transport Proteins Mitochondrial Permeability Transition Pore Mitochondrial Proton-Translocating ATPases - chemistry Mitochondrial Proton-Translocating ATPases - metabolism Oligomycin Protein Subunits - chemistry Protein Subunits - metabolism Review Themed Section: Review
ISSN:	0007-1188, 1476-5381, 1476-5381
On-line přístup:	Získat plný text
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