In vivo human head MRI at 10.5T: A radiofrequency safety study and preliminary imaging results

Purpose The purpose of this study is to safely acquire the first human head images at 10.5T. Methods To ensure safety of subjects, we validated the electromagnetic simulation model of our coil. We obtained quantitative agreement between simulated and experimental B1+ and specific absorption rate (SA...

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Veröffentlicht in:	Magnetic resonance in medicine Jg. 84; H. 1; S. 484 - 496
Hauptverfasser:	Sadeghi‐Tarakameh, Alireza, DelaBarre, Lance, Lagore, Russell L., Torrado‐Carvajal, Angel, Wu, Xiaoping, Grant, Andrea, Adriany, Gregor, Metzger, Gregory J., Van de Moortele, Pierre‐Francois, Ugurbil, Kamil, Atalar, Ergin, Eryaman, Yigitcan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Wiley Subscription Services, Inc 01.07.2020
Schlagworte:	10.5T Computer Simulation head imaging Human subjects Humans Image acquisition Image transmission In vivo methods and tests Magnetic Resonance Imaging Mathematical models MRI Phantoms, Imaging Quadratures Radio frequency Radio Waves radiofrequency safety Safety ultra‐high field Workflow head imaging MRI ultra-high field radiofrequency safety 10.5T
ISSN:	0740-3194, 1522-2594, 1522-2594
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Abstract	Purpose The purpose of this study is to safely acquire the first human head images at 10.5T. Methods To ensure safety of subjects, we validated the electromagnetic simulation model of our coil. We obtained quantitative agreement between simulated and experimental B1+ and specific absorption rate (SAR). Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects. We conducted all experiments and imaging sessions in a controlled radiofrequency safety lab and the whole‐body 10.5T scanner in the Center for Magnetic Resonance Research. Results Quantitative agreement between the simulated and experimental results was obtained including S‐parameters, B1+ maps, and SAR. We calculated peak 10 g average SAR using 4 different realistic human body models for a quadrature excitation and demonstrated that the peak 10 g SAR variation between subjects was less than 30%. We calculated safe power limits based on this set and used those limits to acquire T2‐ and T2∗‐weighted images of human subjects at 10.5T. Conclusions In this study, we acquired the first in vivo human head images at 10.5T using an 8‐channel transmit/receive coil. We implemented and expanded a previously proposed workflow to validate the electromagnetic simulation model of the 8‐channel transmit/receive coil. Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects.
AbstractList	PurposeThe purpose of this study is to safely acquire the first human head images at 10.5T.MethodsTo ensure safety of subjects, we validated the electromagnetic simulation model of our coil. We obtained quantitative agreement between simulated and experimental B1+ and specific absorption rate (SAR). Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects. We conducted all experiments and imaging sessions in a controlled radiofrequency safety lab and the whole‐body 10.5T scanner in the Center for Magnetic Resonance Research.ResultsQuantitative agreement between the simulated and experimental results was obtained including S‐parameters, B1+ maps, and SAR. We calculated peak 10 g average SAR using 4 different realistic human body models for a quadrature excitation and demonstrated that the peak 10 g SAR variation between subjects was less than 30%. We calculated safe power limits based on this set and used those limits to acquire T2‐ and T2∗‐weighted images of human subjects at 10.5T.ConclusionsIn this study, we acquired the first in vivo human head images at 10.5T using an 8‐channel transmit/receive coil. We implemented and expanded a previously proposed workflow to validate the electromagnetic simulation model of the 8‐channel transmit/receive coil. Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects. The purpose of this study is to safely acquire the first human head images at 10.5T.PURPOSEThe purpose of this study is to safely acquire the first human head images at 10.5T.To ensure safety of subjects, we validated the electromagnetic simulation model of our coil. We obtained quantitative agreement between simulated and experimental B1+ and specific absorption rate (SAR). Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects. We conducted all experiments and imaging sessions in a controlled radiofrequency safety lab and the whole-body 10.5T scanner in the Center for Magnetic Resonance Research.METHODSTo ensure safety of subjects, we validated the electromagnetic simulation model of our coil. We obtained quantitative agreement between simulated and experimental B1+ and specific absorption rate (SAR). Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects. We conducted all experiments and imaging sessions in a controlled radiofrequency safety lab and the whole-body 10.5T scanner in the Center for Magnetic Resonance Research.Quantitative agreement between the simulated and experimental results was obtained including S-parameters, B1+ maps, and SAR. We calculated peak 10 g average SAR using 4 different realistic human body models for a quadrature excitation and demonstrated that the peak 10 g SAR variation between subjects was less than 30%. We calculated safe power limits based on this set and used those limits to acquire T2 - and T2∗ -weighted images of human subjects at 10.5T.RESULTSQuantitative agreement between the simulated and experimental results was obtained including S-parameters, B1+ maps, and SAR. We calculated peak 10 g average SAR using 4 different realistic human body models for a quadrature excitation and demonstrated that the peak 10 g SAR variation between subjects was less than 30%. We calculated safe power limits based on this set and used those limits to acquire T2 - and T2∗ -weighted images of human subjects at 10.5T.In this study, we acquired the first in vivo human head images at 10.5T using an 8-channel transmit/receive coil. We implemented and expanded a previously proposed workflow to validate the electromagnetic simulation model of the 8-channel transmit/receive coil. Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects.CONCLUSIONSIn this study, we acquired the first in vivo human head images at 10.5T using an 8-channel transmit/receive coil. We implemented and expanded a previously proposed workflow to validate the electromagnetic simulation model of the 8-channel transmit/receive coil. Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects. The purpose of this study is to safely acquire the first human head images at 10.5T. To ensure safety of subjects, we validated the electromagnetic simulation model of our coil. We obtained quantitative agreement between simulated and experimental and specific absorption rate (SAR). Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects. We conducted all experiments and imaging sessions in a controlled radiofrequency safety lab and the whole-body 10.5T scanner in the Center for Magnetic Resonance Research. Quantitative agreement between the simulated and experimental results was obtained including S-parameters, maps, and SAR. We calculated peak 10 g average SAR using 4 different realistic human body models for a quadrature excitation and demonstrated that the peak 10 g SAR variation between subjects was less than 30%. We calculated safe power limits based on this set and used those limits to acquire T - and -weighted images of human subjects at 10.5T. In this study, we acquired the first in vivo human head images at 10.5T using an 8-channel transmit/receive coil. We implemented and expanded a previously proposed workflow to validate the electromagnetic simulation model of the 8-channel transmit/receive coil. Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects. Purpose The purpose of this study is to safely acquire the first human head images at 10.5T. Methods To ensure safety of subjects, we validated the electromagnetic simulation model of our coil. We obtained quantitative agreement between simulated and experimental B1+ and specific absorption rate (SAR). Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects. We conducted all experiments and imaging sessions in a controlled radiofrequency safety lab and the whole‐body 10.5T scanner in the Center for Magnetic Resonance Research. Results Quantitative agreement between the simulated and experimental results was obtained including S‐parameters, B1+ maps, and SAR. We calculated peak 10 g average SAR using 4 different realistic human body models for a quadrature excitation and demonstrated that the peak 10 g SAR variation between subjects was less than 30%. We calculated safe power limits based on this set and used those limits to acquire T2‐ and T2∗‐weighted images of human subjects at 10.5T. Conclusions In this study, we acquired the first in vivo human head images at 10.5T using an 8‐channel transmit/receive coil. We implemented and expanded a previously proposed workflow to validate the electromagnetic simulation model of the 8‐channel transmit/receive coil. Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects.
Author	Adriany, Gregor Lagore, Russell L. Van de Moortele, Pierre‐Francois Atalar, Ergin Metzger, Gregory J. Eryaman, Yigitcan Torrado‐Carvajal, Angel Grant, Andrea Sadeghi‐Tarakameh, Alireza Wu, Xiaoping Ugurbil, Kamil DelaBarre, Lance
AuthorAffiliation	1 Department of Electrical and Electronics Engineering, Bilkent University, Ankara, Turkey 2 National Magnetic Resonance Research Center (UMRAM), Ankara, Turkey 4 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 3 Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, Minnesota 5 Medical Image Analysis and Biometry Laboratory, Universidad Rey Juan Carlos, Madrid, Spain
AuthorAffiliation_xml	– name: 2 National Magnetic Resonance Research Center (UMRAM), Ankara, Turkey – name: 3 Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, Minnesota – name: 1 Department of Electrical and Electronics Engineering, Bilkent University, Ankara, Turkey – name: 4 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts – name: 5 Medical Image Analysis and Biometry Laboratory, Universidad Rey Juan Carlos, Madrid, Spain
Author_xml	– sequence: 1 givenname: Alireza orcidid: 0000-0001-5718-6553 surname: Sadeghi‐Tarakameh fullname: Sadeghi‐Tarakameh, Alireza email: alireza@ee.bilkent.edu.tr organization: University of Minnesota – sequence: 2 givenname: Lance surname: DelaBarre fullname: DelaBarre, Lance organization: University of Minnesota – sequence: 3 givenname: Russell L. surname: Lagore fullname: Lagore, Russell L. organization: University of Minnesota – sequence: 4 givenname: Angel orcidid: 0000-0002-1540-2809 surname: Torrado‐Carvajal fullname: Torrado‐Carvajal, Angel organization: Universidad Rey Juan Carlos – sequence: 5 givenname: Xiaoping orcidid: 0000-0001-6021-9088 surname: Wu fullname: Wu, Xiaoping organization: University of Minnesota – sequence: 6 givenname: Andrea surname: Grant fullname: Grant, Andrea organization: University of Minnesota – sequence: 7 givenname: Gregor surname: Adriany fullname: Adriany, Gregor organization: University of Minnesota – sequence: 8 givenname: Gregory J. surname: Metzger fullname: Metzger, Gregory J. organization: University of Minnesota – sequence: 9 givenname: Pierre‐Francois orcidid: 0000-0002-6941-5947 surname: Van de Moortele fullname: Van de Moortele, Pierre‐Francois organization: University of Minnesota – sequence: 10 givenname: Kamil surname: Ugurbil fullname: Ugurbil, Kamil organization: University of Minnesota – sequence: 11 givenname: Ergin orcidid: 0000-0002-6874-6103 surname: Atalar fullname: Atalar, Ergin organization: National Magnetic Resonance Research Center (UMRAM) – sequence: 12 givenname: Yigitcan surname: Eryaman fullname: Eryaman, Yigitcan organization: University of Minnesota
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Snippet	Purpose The purpose of this study is to safely acquire the first human head images at 10.5T. Methods To ensure safety of subjects, we validated the... The purpose of this study is to safely acquire the first human head images at 10.5T. To ensure safety of subjects, we validated the electromagnetic simulation... PurposeThe purpose of this study is to safely acquire the first human head images at 10.5T.MethodsTo ensure safety of subjects, we validated the... The purpose of this study is to safely acquire the first human head images at 10.5T.PURPOSEThe purpose of this study is to safely acquire the first human head...
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SubjectTerms	10.5T Computer Simulation head imaging Human subjects Humans Image acquisition Image transmission In vivo methods and tests Magnetic Resonance Imaging Mathematical models MRI Phantoms, Imaging Quadratures Radio frequency Radio Waves radiofrequency safety Safety ultra‐high field Workflow
Title	In vivo human head MRI at 10.5T: A radiofrequency safety study and preliminary imaging results
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