Cardiac changes associated with vascular aging

Cardiovascular aging is a complex process of adaptive structural and functional changes over time. With advancing age, the arterial tree thickens and decreases in compliance, resulting in increased pulse wave velocity, systolic blood pressure, and left ventricular afterload. In response to these art...

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Veröffentlicht in:Clinical cardiology (Mahwah, N.J.) Jg. 43; H. 2; S. 92 - 98
Hauptverfasser: Singam, Narayana Sarma V., Fine, Christopher, Fleg, Jerome L.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Wiley Periodicals, Inc 01.02.2020
John Wiley & Sons, Inc
Schlagworte:
Age
Age Factors
Aged
Aged, 80 and over
Aging
Aging - metabolism
Aging - pathology
aging and the cardiovascular system
Animals
Atherosclerosis
Blood pressure
Calcification
Cardiac arrhythmia
cardiac mechanics
Cardiovascular disease
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - pathology
Cardiovascular Diseases - physiopathology
Cardiovascular Diseases - therapy
Cardiovascular System - metabolism
Cardiovascular System - pathology
Cardiovascular System - physiopathology
Compliance
Coronary vessels
Diabetes
echocardiography
Electrocardiography
Heart failure
Hemodynamics
Humans
Hypertension
Male
Mortality
Older people
Prognosis
remodeling
Review
Reviews
Risk Factors
Vascular Stiffness
Ventricular Function
heart failure
remodeling
cardiac mechanics
aging and the cardiovascular system
echocardiography
ISSN:0160-9289, 1932-8737, 1932-8737
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Zusammenfassung:Cardiovascular aging is a complex process of adaptive structural and functional changes over time. With advancing age, the arterial tree thickens and decreases in compliance, resulting in increased pulse wave velocity, systolic blood pressure, and left ventricular afterload. In response to these arterial changes, the myocardium remodels to maintain systolic function and diastolic filling. These adaptive mechanisms are not necessarily pathologic but increase the susceptibility for myocardial ischemia and heart failure in the presence of common age‐associated comorbidities. This article reviews the pathophysiology of cardiovascular aging and discusses therapeutic interventions that may ameliorate these processes.
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ISSN:0160-9289
1932-8737
1932-8737
DOI:10.1002/clc.23313