Partial volume correction for quantitative CEST imaging of acute ischemic stroke

Purpose Contributions of cerebrospinal fluid (CSF) have not been previously taken into account in the quantification of APT CEST effects, and correction for the dilution of CEST effects by CSF may allow for more robust measurement of CEST signals. The objective of this study was to compare the robus...

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Vydáno v:Magnetic resonance in medicine Ročník 82; číslo 5; s. 1920 - 1928
Hlavní autoři: Msayib, Y., Harston, G. W. J., Sheerin, F., Blockley, N. P., Okell, T. W., Jezzard, P., Kennedy, J., Chappell, M. A.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Wiley Subscription Services, Inc 01.11.2019
John Wiley and Sons Inc
Témata:
acute ischemic stroke
Adult
Aged
amide proton transfer
Brain Ischemia - diagnostic imaging
Cerebrospinal fluid
CEST MRI
Dilution
Female
Healthy Volunteers
Humans
Image Interpretation, Computer-Assisted - methods
Ischemia
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Note—Computer Processing and Modeling
partial volume correction
Prospective Studies
quantification
Reproducibility
Reproducibility of Results
Retrospective Studies
Stroke - diagnostic imaging
amide proton transfer
CEST MRI
partial volume correction
quantification
acute ischemic stroke
ISSN:0740-3194, 1522-2594, 1522-2594
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Shrnutí:Purpose Contributions of cerebrospinal fluid (CSF) have not been previously taken into account in the quantification of APT CEST effects, and correction for the dilution of CEST effects by CSF may allow for more robust measurement of CEST signals. The objective of this study was to compare the robustness of a partial volume (PV) correction model against a standard (4‐pool) multi‐pool model as far as their ability to quantify CEST effects in healthy, normal, and pathological tissue. Methods MRI data from 12 patients presenting with ischemic stroke, and 6 healthy subjects, were retrospectively analyzed. CEST signals derived from a 4‐pool model and a PV correction model were compared for repeatability and pathological tissue contrast. The effect of PV correction (PVC) was assessed within 3 ranges of tissue PV estimate (PVE): high PVE voxels, low PVE voxels, and the whole slice. Results In voxels with a high tissue PVE, PV correction did not make a significant difference to absolute APTR*. In low PVE voxels, the PVC model exhibited a significantly decreased ischemic core signal. The PVC measures exhibited higher repeatability between healthy subjects (4 pools: 3.4%, PVC: 2.4%) while maintaining a similar ischemic core CNR (0.7) to the 4‐pool model. In whole slice analysis it was found that both models exhibited similar results. Conclusions PV correction yielded a measure of APT effects that was more repeatable than standard 4‐pool analysis while achieving a similar CNR in pathological tissue, suggesting that PV‐corrected analysis was more robust at low values of tissue PVE.
Bibliografie:james.kennedy@rdm.ox.ac.uk
The underlying data associated with figures in this study are available from the Oxford University Research Archive (ORA‐Data) (DOI: 10.5287/bodleian:9RmBjG1aV). For enquiries regarding the clinical data, contact JK
DATA STATEMENT
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DATA STATEMENT The underlying data associated with figures in this study are available from the Oxford University Research Archive (ORA‐Data) (DOI: 10.5287/bodleian:9RmBjG1aV). For enquiries regarding the clinical data, contact JK (james.kennedy@rdm.ox.ac.uk).
ISSN:0740-3194
1522-2594
1522-2594
DOI:10.1002/mrm.27872