Partial volume correction for quantitative CEST imaging of acute ischemic stroke

Purpose Contributions of cerebrospinal fluid (CSF) have not been previously taken into account in the quantification of APT CEST effects, and correction for the dilution of CEST effects by CSF may allow for more robust measurement of CEST signals. The objective of this study was to compare the robus...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Magnetic resonance in medicine Ročník 82; číslo 5; s. 1920 - 1928
Hlavní autori:	Msayib, Y., Harston, G. W. J., Sheerin, F., Blockley, N. P., Okell, T. W., Jezzard, P., Kennedy, J., Chappell, M. A.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Wiley Subscription Services, Inc 01.11.2019 John Wiley and Sons Inc
Predmet:	acute ischemic stroke Adult Aged amide proton transfer Brain Ischemia - diagnostic imaging Cerebrospinal fluid CEST MRI Dilution Female Healthy Volunteers Humans Image Interpretation, Computer-Assisted - methods Ischemia Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Note—Computer Processing and Modeling partial volume correction Prospective Studies quantification Reproducibility Reproducibility of Results Retrospective Studies Stroke - diagnostic imaging amide proton transfer CEST MRI partial volume correction quantification acute ischemic stroke
ISSN:	0740-3194, 1522-2594, 1522-2594
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	Purpose Contributions of cerebrospinal fluid (CSF) have not been previously taken into account in the quantification of APT CEST effects, and correction for the dilution of CEST effects by CSF may allow for more robust measurement of CEST signals. The objective of this study was to compare the robustness of a partial volume (PV) correction model against a standard (4‐pool) multi‐pool model as far as their ability to quantify CEST effects in healthy, normal, and pathological tissue. Methods MRI data from 12 patients presenting with ischemic stroke, and 6 healthy subjects, were retrospectively analyzed. CEST signals derived from a 4‐pool model and a PV correction model were compared for repeatability and pathological tissue contrast. The effect of PV correction (PVC) was assessed within 3 ranges of tissue PV estimate (PVE): high PVE voxels, low PVE voxels, and the whole slice. Results In voxels with a high tissue PVE, PV correction did not make a significant difference to absolute APTR*. In low PVE voxels, the PVC model exhibited a significantly decreased ischemic core signal. The PVC measures exhibited higher repeatability between healthy subjects (4 pools: 3.4%, PVC: 2.4%) while maintaining a similar ischemic core CNR (0.7) to the 4‐pool model. In whole slice analysis it was found that both models exhibited similar results. Conclusions PV correction yielded a measure of APT effects that was more repeatable than standard 4‐pool analysis while achieving a similar CNR in pathological tissue, suggesting that PV‐corrected analysis was more robust at low values of tissue PVE.
Bibliografia:	james.kennedy@rdm.ox.ac.uk The underlying data associated with figures in this study are available from the Oxford University Research Archive (ORA‐Data) (DOI: 10.5287/bodleian:9RmBjG1aV). For enquiries regarding the clinical data, contact JK DATA STATEMENT . ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 DATA STATEMENT The underlying data associated with figures in this study are available from the Oxford University Research Archive (ORA‐Data) (DOI: 10.5287/bodleian:9RmBjG1aV). For enquiries regarding the clinical data, contact JK (james.kennedy@rdm.ox.ac.uk).
ISSN:	0740-3194 1522-2594 1522-2594
DOI:	10.1002/mrm.27872