Autologous lipoaspirate as a new treatment of vulvar lichen sclerosus: A review on literature

Lichen sclerosus (LS) is a chronic inflammatory dermatosis that mostly affects the genital and anal skin areas. Symptoms may vary from pruritis and pain to sexual dysfunction; however, LS can also be asymptomatic. LS occurs at all ages and in both sexes. Approximately 5% of all women affected by vul...

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Vydané v:Experimental dermatology Ročník 31; číslo 5; s. 689 - 699
Hlavní autori: Sluis, Nanouk, Scheers, Esther C.A.H., Krenning, Guido, Lei, Berend, Oonk, Maaike H.M., Dongen, Joris A.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Denmark Wiley Subscription Services, Inc 01.05.2022
John Wiley and Sons Inc
Predmet:
Adipose tissue
ageing
Autografts
dermal
Female
Fibrosis
Humans
Inflammation
lichen sclerosus
Lichen Sclerosus et Atrophicus - pathology
Lichen Sclerosus et Atrophicus - therapy
lipoaspirate
Pain
Pruritus
Reconstructive surgery
regeneration
Review
Skin - pathology
Squamous cell carcinoma
stem cells
stromal vascular fraction
vulvar
Vulvar Lichen Sclerosus - pathology
Vulvar Lichen Sclerosus - therapy
Vulvar Neoplasms - pathology
lipoaspirate
stem cells
ageing
regeneration
stromal vascular fraction
vulvar
fibrosis
dermal
lichen sclerosus
ISSN:0906-6705, 1600-0625, 1600-0625
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Popis
Shrnutí:Lichen sclerosus (LS) is a chronic inflammatory dermatosis that mostly affects the genital and anal skin areas. Symptoms may vary from pruritis and pain to sexual dysfunction; however, LS can also be asymptomatic. LS occurs at all ages and in both sexes. Approximately 5% of all women affected by vulvar LS will develop vulvar squamous cell carcinoma. Topical treatment is safe but less effective resulting in chronic course in most patients, who suffer from persistent itching and pain. In severe cases of therapy‐resistant LS, there is no adequate treatment. Fat grafting is a novel regenerative therapy to reduce dermal fibrosis. The therapeutic effect of adipose tissue grafts for LS is already investigated in various pioneering studies. This review provides an overview of these studies and the putative mechanisms‐of‐action of fat grafting to treat LS.
Bibliografia:Nanouk van der Sluis and Esther C.A.H. Scheers are equally shared first author.
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ISSN:0906-6705
1600-0625
1600-0625
DOI:10.1111/exd.14561