Genome-wide analysis of the FOXA1 transcriptional regulatory network identifies super enhancer associated LncRNAs in tamoxifen resistance
Breast cancer is the leading cause of death in female cancers, and what’s worse, tamoxifen resistance occurs in almost 30% breast cancer patients and has seriously attenuated the therapeutic effect. It is widely studied that epigenetic regulation has played important role in the development of tamox...
Gespeichert in:
| Veröffentlicht in: | Frontiers in genetics Jg. 13; S. 992444 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Frontiers Media S.A
20.09.2022
|
| Schlagworte: | |
| ISSN: | 1664-8021, 1664-8021 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Breast cancer is the leading cause of death in female cancers, and what’s worse, tamoxifen resistance occurs in almost 30% breast cancer patients and has seriously attenuated the therapeutic effect. It is widely studied that epigenetic regulation has played important role in the development of tamoxifen resistance. FOXA1 is a pioneer transcription factor that can translate epigenetic signature into transcription regulation and also drive genome-wide enhancer reprogramming in breast cancer. However, the chromatin super enhancer landscape orchestrated by FOXA1 and the key downstream targets of the FOXA1 oncogenic network in tamoxifen resistance remain elusive. Through analyzing the FOXA1 ChIP-seq data in tamoxifen sensitive MCF7 and tamoxifen resistant MCF7/TamR cells, we show that the FOXA1 chromatin occupancy is enhanced in both the promoter and enhancer regions, and the recruitment events may be E2 dependent in both MCF7 and MCF7/TamR cells. By integratively analyzing the FOXA1 ChIP-seq data and RNA-seq data of MCF7 and MCF7/TamR cells, we find that the enhanced or reduced FOXA1 chromatin binding densities may synchronize the transcriptional activity in tamoxifen resistance. Besides, we identify 1003 super enhancer associated protein coding genes and five super enhancer associated lncRNAs (ATP1A1−AS1, CASC11, CASC15, KCTD21−AS1, LINC00885) in tamoxifen resistance. By KM survival analysis, we find that high expression level of ATP1A1−AS1 and its sense transcript ATP1A1 indicates favorable clinical outcome among the luminal endocrine treated breast cancer patients. Further coexpression analysis indicates that ATP1A1-AS1 is significantly correlated with ATP1A1, and RT-qPCR results show that they both are downregulated in MCF7/TamR cells. Our study shows that the FOXA1 transcriptional regulatory network may promote the development of tamoxifen resistance, and identifies one super enhancer associated lncRNA ATP1A1-AS1 that may work as promising biomarker or drug target in tamoxifen resistance. |
|---|---|
| AbstractList | Breast cancer is the leading cause of death in female cancers, and what’s worse, tamoxifen resistance occurs in almost 30% breast cancer patients and has seriously attenuated the therapeutic effect. It is widely studied that epigenetic regulation has played important role in the development of tamoxifen resistance. FOXA1 is a pioneer transcription factor that can translate epigenetic signature into transcription regulation and also drive genome-wide enhancer reprogramming in breast cancer. However, the chromatin super enhancer landscape orchestrated by FOXA1 and the key downstream targets of the FOXA1 oncogenic network in tamoxifen resistance remain elusive. Through analyzing the FOXA1 ChIP-seq data in tamoxifen sensitive MCF7 and tamoxifen resistant MCF7/TamR cells, we show that the FOXA1 chromatin occupancy is enhanced in both the promoter and enhancer regions, and the recruitment events may be E2 dependent in both MCF7 and MCF7/TamR cells. By integratively analyzing the FOXA1 ChIP-seq data and RNA-seq data of MCF7 and MCF7/TamR cells, we find that the enhanced or reduced FOXA1 chromatin binding densities may synchronize the transcriptional activity in tamoxifen resistance. Besides, we identify 1003 super enhancer associated protein coding genes and five super enhancer associated lncRNAs (ATP1A1−AS1, CASC11, CASC15, KCTD21−AS1, LINC00885) in tamoxifen resistance. By KM survival analysis, we find that high expression level of ATP1A1−AS1 and its sense transcript ATP1A1 indicates favorable clinical outcome among the luminal endocrine treated breast cancer patients. Further coexpression analysis indicates that ATP1A1-AS1 is significantly correlated with ATP1A1, and RT-qPCR results show that they both are downregulated in MCF7/TamR cells. Our study shows that the FOXA1 transcriptional regulatory network may promote the development of tamoxifen resistance, and identifies one super enhancer associated lncRNA ATP1A1-AS1 that may work as promising biomarker or drug target in tamoxifen resistance. Breast cancer is the leading cause of death in female cancers, and what's worse, tamoxifen resistance occurs in almost 30% breast cancer patients and has seriously attenuated the therapeutic effect. It is widely studied that epigenetic regulation has played important role in the development of tamoxifen resistance. FOXA1 is a pioneer transcription factor that can translate epigenetic signature into transcription regulation and also drive genome-wide enhancer reprogramming in breast cancer. However, the chromatin super enhancer landscape orchestrated by FOXA1 and the key downstream targets of the FOXA1 oncogenic network in tamoxifen resistance remain elusive. Through analyzing the FOXA1 ChIP-seq data in tamoxifen sensitive MCF7 and tamoxifen resistant MCF7/TamR cells, we show that the FOXA1 chromatin occupancy is enhanced in both the promoter and enhancer regions, and the recruitment events may be E2 dependent in both MCF7 and MCF7/TamR cells. By integratively analyzing the FOXA1 ChIP-seq data and RNA-seq data of MCF7 and MCF7/TamR cells, we find that the enhanced or reduced FOXA1 chromatin binding densities may synchronize the transcriptional activity in tamoxifen resistance. Besides, we identify 1003 super enhancer associated protein coding genes and five super enhancer associated lncRNAs (ATP1A1-AS1, CASC11, CASC15, KCTD21-AS1, LINC00885) in tamoxifen resistance. By KM survival analysis, we find that high expression level of ATP1A1-AS1 and its sense transcript ATP1A1 indicates favorable clinical outcome among the luminal endocrine treated breast cancer patients. Further coexpression analysis indicates that ATP1A1-AS1 is significantly correlated with ATP1A1, and RT-qPCR results show that they both are downregulated in MCF7/TamR cells. Our study shows that the FOXA1 transcriptional regulatory network may promote the development of tamoxifen resistance, and identifies one super enhancer associated lncRNA ATP1A1-AS1 that may work as promising biomarker or drug target in tamoxifen resistance.Breast cancer is the leading cause of death in female cancers, and what's worse, tamoxifen resistance occurs in almost 30% breast cancer patients and has seriously attenuated the therapeutic effect. It is widely studied that epigenetic regulation has played important role in the development of tamoxifen resistance. FOXA1 is a pioneer transcription factor that can translate epigenetic signature into transcription regulation and also drive genome-wide enhancer reprogramming in breast cancer. However, the chromatin super enhancer landscape orchestrated by FOXA1 and the key downstream targets of the FOXA1 oncogenic network in tamoxifen resistance remain elusive. Through analyzing the FOXA1 ChIP-seq data in tamoxifen sensitive MCF7 and tamoxifen resistant MCF7/TamR cells, we show that the FOXA1 chromatin occupancy is enhanced in both the promoter and enhancer regions, and the recruitment events may be E2 dependent in both MCF7 and MCF7/TamR cells. By integratively analyzing the FOXA1 ChIP-seq data and RNA-seq data of MCF7 and MCF7/TamR cells, we find that the enhanced or reduced FOXA1 chromatin binding densities may synchronize the transcriptional activity in tamoxifen resistance. Besides, we identify 1003 super enhancer associated protein coding genes and five super enhancer associated lncRNAs (ATP1A1-AS1, CASC11, CASC15, KCTD21-AS1, LINC00885) in tamoxifen resistance. By KM survival analysis, we find that high expression level of ATP1A1-AS1 and its sense transcript ATP1A1 indicates favorable clinical outcome among the luminal endocrine treated breast cancer patients. Further coexpression analysis indicates that ATP1A1-AS1 is significantly correlated with ATP1A1, and RT-qPCR results show that they both are downregulated in MCF7/TamR cells. Our study shows that the FOXA1 transcriptional regulatory network may promote the development of tamoxifen resistance, and identifies one super enhancer associated lncRNA ATP1A1-AS1 that may work as promising biomarker or drug target in tamoxifen resistance. |
| Author | Liu, Guangzhi Zhang, Qian Zhang, Xiulei |
| AuthorAffiliation | 2 Henan Provincial Key Medical Laboratory of Genetics , Henan Provincial People’s Hospital , Zhengzhou University , Zhengzhou , China 1 Department of Microbiome Laboratory , Henan Provincial People’s Hospital , Zhengzhou University , Zhengzhou , China |
| AuthorAffiliation_xml | – name: 2 Henan Provincial Key Medical Laboratory of Genetics , Henan Provincial People’s Hospital , Zhengzhou University , Zhengzhou , China – name: 1 Department of Microbiome Laboratory , Henan Provincial People’s Hospital , Zhengzhou University , Zhengzhou , China |
| Author_xml | – sequence: 1 givenname: Xiulei surname: Zhang fullname: Zhang, Xiulei – sequence: 2 givenname: Qian surname: Zhang fullname: Zhang, Qian – sequence: 3 givenname: Guangzhi surname: Liu fullname: Liu, Guangzhi |
| BookMark | eNp9ks1uEzEUhUeoSJTSB2DnJZsJ_hvPeIMUVbRUiloJgcTOcuzrxGXGDraHkkfgrXGaqqIs8MZX9jnfvbLP6-YkxABN85bgBWODfO82EGBBMaULKSnn_EVzSoTg7YApOfmrftWc53yH6-KSMcZPm99XEOIE7b23gHTQ4z77jKJDZQvo8vbbkqCSdMgm-V3xsQpQgs086hLTHgUo9zF9R9UcinceMsrzDhKCsNXB1ELnHI3XBSxaBfP5ZpmRD6joKf7yDkKF1X7loH3TvHR6zHD-uJ81Xy8_frn41K5ur64vlqvWcE5L6zozUEucpRas643kct0Na0F478AIjntiO9f1PddOSA7Aqeux7Jg0ZLDg2FlzfeTaqO_ULvlJp72K2quHg5g2SqfizQiKMCGk4MQyQbnrpDbQWUZlTyXVVprK-nBk7eb1BNbUV0h6fAZ9fhP8Vm3iT1XnwVzQCnj3CEjxxwy5qMlnA-OoA8Q5K9pTRjrRcVyl5Cg1KeacwD21IVgdYqAeYqAOMVDHGFRP_4_H-KIP_1in8eN_nH8Azny-2A |
| CitedBy_id | crossref_primary_10_1186_s12964_024_01599_6 crossref_primary_10_1007_s10495_023_01831_7 crossref_primary_10_1111_jcmm_70296 crossref_primary_10_3390_ijms25063103 crossref_primary_10_3390_ijms24108733 |
| Cites_doi | 10.2196/27633 10.1016/s0140-6736(12)61963-1 10.1155/2020/9031723 10.1038/nprot.2013.150 10.1016/j.cell.2013.03.035 10.3892/or.2022.8341 10.1016/S0140-6736(05)66544-0 10.1080/15476286.2020.1712895 10.1016/j.cell.2016.02.067 10.1016/j.ccell.2016.03.010 10.14806/ej.17.1.200 10.2147/OTT.S321669 10.1038/nmeth.3317 10.1093/nar/gkw257 10.1371/journal.pone.0132285 10.1093/bioinformatics/btu638 10.1093/bioinformatics/btp352 10.1089/omi.2011.0118 10.1016/j.cell.2013.09.053 10.1073/pnas.1911584116 10.1186/1471-2407-13-174 10.1038/s41467-021-22024-3 10.3389/fphar.2020.592912 10.1093/jmcb/mjab018 10.1016/j.celrep.2019.09.032 10.1038/ng.730 10.1186/s13059-014-0550-8 10.1093/bioinformatics/btv145 10.1186/gb-2008-9-9-r137 10.3727/096504016x14549667334007 10.3322/caac.21660 10.1038/nmeth.1923 10.1134/s0006297918050139 |
| ContentType | Journal Article |
| Copyright | Copyright © 2022 Zhang, Zhang and Liu. Copyright © 2022 Zhang, Zhang and Liu. 2022 Zhang, Zhang and Liu |
| Copyright_xml | – notice: Copyright © 2022 Zhang, Zhang and Liu. – notice: Copyright © 2022 Zhang, Zhang and Liu. 2022 Zhang, Zhang and Liu |
| DBID | AAYXX CITATION 7X8 5PM DOA |
| DOI | 10.3389/fgene.2022.992444 |
| DatabaseName | CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals (DOAJ) |
| DatabaseTitle | CrossRef MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| DocumentTitleAlternate | Zhang et al |
| EISSN | 1664-8021 |
| ExternalDocumentID | oai_doaj_org_article_13669641d3624f59ace5d3297292ad9c PMC9530462 10_3389_fgene_2022_992444 |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFS ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RNS RPM 7X8 5PM |
| ID | FETCH-LOGICAL-c442t-f5c82d1fd2dedf7c949b58b6147fec64071d5f5774af694ee42f709539c18def3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 6 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000864518700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1664-8021 |
| IngestDate | Fri Oct 03 12:47:34 EDT 2025 Thu Aug 21 18:39:52 EDT 2025 Thu Sep 04 20:08:42 EDT 2025 Sat Nov 29 06:21:57 EST 2025 Tue Nov 18 21:26:13 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c442t-f5c82d1fd2dedf7c949b58b6147fec64071d5f5774af694ee42f709539c18def3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Ubald Soto, Loma Linda University, United States Reviewed by: Kenan Sevinç, Koç University, Turkey This article was submitted to RNA, a section of the journal Frontiers in Genetics Shrikanth Gadad, Texas Tech University Health Sciences Center El Paso, United States |
| OpenAccessLink | https://doaj.org/article/13669641d3624f59ace5d3297292ad9c |
| PQID | 2723156540 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_13669641d3624f59ace5d3297292ad9c pubmedcentral_primary_oai_pubmedcentral_nih_gov_9530462 proquest_miscellaneous_2723156540 crossref_primary_10_3389_fgene_2022_992444 crossref_citationtrail_10_3389_fgene_2022_992444 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-09-20 |
| PublicationDateYYYYMMDD | 2022-09-20 |
| PublicationDate_xml | – month: 09 year: 2022 text: 2022-09-20 day: 20 |
| PublicationDecade | 2020 |
| PublicationTitle | Frontiers in genetics |
| PublicationYear | 2022 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Yao (B29) 2020; 11 Group (B8) 2005; 365 Hnisz (B10) 2013; 155 Li (B17) 2016; 23 Zhang (B34) 2020; 2020 Duan (B5) 2021; 13 Kim (B12) 2015; 12 Ramírez (B21) 2016; 44 Andrews (B2) 2010 Zhang (B35) 2021; 14 Anders (B1) 2015; 31 Lánczky (B13) 2021; 23 Ham (B9) 2022; 48 Cocce (B3) 2019; 29 Stark (B23) 2011 Loh (B18) 2013; 13 Yu (B31) 2015; 31 Davies (B4) 2013; 381 Swinstead (B25) 2016; 165 Martin (B20) 2011; 17 Sung (B24) 2021; 71 Hurtado (B11) 2011; 43 Garcia-Martinez (B7) 2021; 12 Whyte (B27) 2013; 153 Woo (B28) 2015; 10 Zhang (B33) 2018; 83 Lee (B15) 2020; 17 Yu (B30) 2012; 16 Fu (B6) 2019; 116 Li (B16) 2009; 25 Wang (B26) 2013; 8 Love (B19) 2014; 15 Zhang (B32) 2008; 9 Langmead (B14) 2012; 9 Schmitt (B22) 2016; 29 |
| References_xml | – volume: 23 start-page: e27633 year: 2021 ident: B13 article-title: Web-Based survival analysis tool tailored for medical research (KMplot): Development and implementation publication-title: J. Med. Internet Res. doi: 10.2196/27633 – volume: 381 start-page: 805 year: 2013 ident: B4 article-title: Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial publication-title: Lancet doi: 10.1016/s0140-6736(12)61963-1 – volume-title: DiffBind differential binding analysis of ChIP-Seq peak data year: 2011 ident: B23 – volume: 2020 start-page: 1 year: 2020 ident: B34 article-title: Identification and analysis of estrogen receptor α promoting tamoxifen resistance-related lncRNAs publication-title: BioMed Res. Int. doi: 10.1155/2020/9031723 – volume: 8 start-page: 2502 year: 2013 ident: B26 article-title: Target analysis by integration of transcriptome and ChIP-seq data with BETA publication-title: Nat. Protoc. doi: 10.1038/nprot.2013.150 – volume: 153 start-page: 307 year: 2013 ident: B27 article-title: Master transcription factors and mediator establish super-enhancers at key cell identity genes publication-title: Cell doi: 10.1016/j.cell.2013.03.035 – volume: 48 start-page: 130 year: 2022 ident: B9 article-title: β-catenin blockers enhance the effect of CDK4/6 inhibitors on stemness and proliferation suppression in endocrine-resistant breast cancer cells publication-title: Oncol. Rep. doi: 10.3892/or.2022.8341 – volume: 365 start-page: 1687 year: 2005 ident: B8 article-title: Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials publication-title: Lancet doi: 10.1016/S0140-6736(05)66544-0 – volume: 17 start-page: 1550 year: 2020 ident: B15 article-title: Enhancer RNAs in cancer: Regulation, mechanisms and therapeutic potential publication-title: RNA Biol. doi: 10.1080/15476286.2020.1712895 – volume: 165 start-page: 593 year: 2016 ident: B25 article-title: Steroid receptors reprogram FoxA1 occupancy through dynamic chromatin transitions publication-title: Cell doi: 10.1016/j.cell.2016.02.067 – volume: 29 start-page: 452 year: 2016 ident: B22 article-title: Long noncoding RNAs in cancer pathways publication-title: Cancer Cell doi: 10.1016/j.ccell.2016.03.010 – volume: 17 start-page: 10 year: 2011 ident: B20 article-title: Cutadapt removes adapter sequences from high-throughput sequencing reads publication-title: EMBnet J. doi: 10.14806/ej.17.1.200 – volume: 14 start-page: 4427 year: 2021 ident: B35 article-title: TP53 mutation related and directly regulated lncRNA prognosis markers in hepatocellular carcinoma publication-title: Ott doi: 10.2147/OTT.S321669 – volume: 12 start-page: 357 year: 2015 ident: B12 article-title: Hisat: A fast spliced aligner with low memory requirements publication-title: Nat. Methods doi: 10.1038/nmeth.3317 – volume: 44 start-page: W160 year: 2016 ident: B21 article-title: deepTools2: a next generation web server for deep-sequencing data analysis publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkw257 – volume: 10 start-page: e0132285 year: 2015 ident: B28 article-title: Inhibition of aerobic glycolysis represses akt/mTOR/HIF-1α Axis and restores tamoxifen sensitivity in antiestrogen-resistant breast cancer cells publication-title: PLoS One doi: 10.1371/journal.pone.0132285 – volume: 31 start-page: 166 year: 2015 ident: B1 article-title: HTSeq-a Python framework to work with high-throughput sequencing data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu638 – volume: 25 start-page: 2078 year: 2009 ident: B16 article-title: The sequence alignment/map format and SAMtools publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp352 – volume: 16 start-page: 284 year: 2012 ident: B30 article-title: clusterProfiler: an R package for comparing biological themes among gene clusters publication-title: OMICS A J. Integr. Biol. doi: 10.1089/omi.2011.0118 – volume: 155 start-page: 934 year: 2013 ident: B10 article-title: Super-enhancers in the control of cell identity and disease publication-title: Cell doi: 10.1016/j.cell.2013.09.053 – volume-title: FastQC: A quality control tool for high throughput sequence data year: 2010 ident: B2 – volume: 116 start-page: 26823 year: 2019 ident: B6 article-title: FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1911584116 – volume: 13 start-page: 174 year: 2013 ident: B18 article-title: The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer publication-title: BMC Cancer doi: 10.1186/1471-2407-13-174 – volume: 12 start-page: 1786 year: 2021 ident: B7 article-title: Epigenetic mechanisms in breast cancer therapy and resistance publication-title: Nat. Commun. doi: 10.1038/s41467-021-22024-3 – volume: 11 start-page: 592912 year: 2020 ident: B29 article-title: Progress in the understanding of the mechanism of tamoxifen resistance in breast cancer publication-title: Front. Pharmacol. doi: 10.3389/fphar.2020.592912 – volume: 13 start-page: 433 year: 2021 ident: B5 article-title: Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells publication-title: J. Mol. Cell Biol. doi: 10.1093/jmcb/mjab018 – volume: 29 start-page: 889 year: 2019 ident: B3 article-title: The lineage determining factor GRHL2 collaborates with FOXA1 to establish a targetable pathway in endocrine therapy-resistant breast cancer publication-title: Cell Rep. doi: 10.1016/j.celrep.2019.09.032 – volume: 43 start-page: 27 year: 2011 ident: B11 article-title: FOXA1 is a key determinant of estrogen receptor function and endocrine response publication-title: Nat. Genet. doi: 10.1038/ng.730 – volume: 15 start-page: 550 year: 2014 ident: B19 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – volume: 31 start-page: 2382 year: 2015 ident: B31 article-title: ChIPseeker: An R/bioconductor package for ChIP peak annotation, comparison and visualization publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv145 – volume: 9 start-page: R137 year: 2008 ident: B32 article-title: Model-based analysis of ChIP-seq (MACS) publication-title: Genome Biol. doi: 10.1186/gb-2008-9-9-r137 – volume: 23 start-page: 205 year: 2016 ident: B17 article-title: Regulation of lncRNA and its role in cancer metastasis publication-title: Oncol. Res. doi: 10.3727/096504016x14549667334007 – volume: 71 start-page: 209 year: 2021 ident: B24 article-title: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA A Cancer J. Clin. doi: 10.3322/caac.21660 – volume: 9 start-page: 357 year: 2012 ident: B14 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nat. Methods doi: 10.1038/nmeth.1923 – volume: 83 start-page: 603 year: 2018 ident: B33 article-title: Downregulation of linc00894-002 contributes to tamoxifen resistance by enhancing the TGF-β signaling pathway publication-title: Biochem. Mosc. doi: 10.1134/s0006297918050139 |
| SSID | ssj0000493334 |
| Score | 2.3304765 |
| Snippet | Breast cancer is the leading cause of death in female cancers, and what’s worse, tamoxifen resistance occurs in almost 30% breast cancer patients and has... Breast cancer is the leading cause of death in female cancers, and what's worse, tamoxifen resistance occurs in almost 30% breast cancer patients and has... |
| SourceID | doaj pubmedcentral proquest crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Enrichment Source Index Database |
| StartPage | 992444 |
| SubjectTerms | ATP1A1-AS1 breast cancer FoxA1 Genetics super enhancer tamoxifen resistance |
| Title | Genome-wide analysis of the FOXA1 transcriptional regulatory network identifies super enhancer associated LncRNAs in tamoxifen resistance |
| URI | https://www.proquest.com/docview/2723156540 https://pubmed.ncbi.nlm.nih.gov/PMC9530462 https://doaj.org/article/13669641d3624f59ace5d3297292ad9c |
| Volume | 13 |
| WOSCitedRecordID | wos000864518700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1664-8021 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000493334 issn: 1664-8021 databaseCode: DOA dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1664-8021 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000493334 issn: 1664-8021 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagAokL4imWR2UkTkihfiWOjwvqwqEsCIG0t8jxQw2iTpVkW3rhzr9mHGerzQUuXHJIHMfxNxl_I0--QehVoYwiuRYZcPk6E1aSrPSSZjUvNfFUelKP6voncr0uNxv1ea_UV8wJS_LAaeKOKC8KVQhqwdMKnyttXG45U0AKmbbKRO9LpNoLpr4n3ss5F2kbE6IwdeQBjyiLydgbBTGHELOFaNTrn5HMeYrk3pqzuofuTmQRL9Mg76MbLjxAt1P5yKuH6Pd7F9ozl1021mE9qYvg1mMgdXj1abOkeIhL0c4xQFddKj3fdlc4pARw3NiUMOR63G_PXYddOI2m0GE9QecsPgnmy3rZ4ybgQZ-1PxvvAnTWR_YJbR-hb6vjr-8-ZFNphcwIwYbM56ZklnrLrLNeGiVUnZc1rNXSOxM396jNfQ7cUPtCCecE8zJK0ylDS-s8f4wOQhvcE4SJ1dpQ6E7yXBiqNPiAItbA4pobT8wCkd08V2bSHY_lL35UEH9EaKoRmipCUyVoFuj19S3nSXTjb43fRvCuG0a97PEEWFE1WVH1LytaoJc76Cv4vuKmiQ6u3fYVk8CAgfUKskByZhOzJ86vhOZ0VOqGCYs__z79H0N8hu7Et465Kow8RwdDt3Uv0C1zMTR9d4huyk15OH4EcPz46_gPVvYPmw |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genome-wide+analysis+of+the+FOXA1+transcriptional+regulatory+network+identifies+super+enhancer+associated+LncRNAs+in+tamoxifen+resistance&rft.jtitle=Frontiers+in+genetics&rft.au=Zhang%2C+Xiulei&rft.au=Zhang%2C+Qian&rft.au=Liu%2C+Guangzhi&rft.date=2022-09-20&rft.issn=1664-8021&rft.eissn=1664-8021&rft.volume=13&rft.spage=992444&rft_id=info:doi/10.3389%2Ffgene.2022.992444&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-8021&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-8021&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-8021&client=summon |