Monocytes treated with human immunodeficiency virus Tat kill uninfected CD4(+) cells by a tumor necrosis factor-related apoptosis-induced ligand-mediated mechanism

The human immunodeficiency virus (HIV) Tat protein has a critical role in viral transcription, but this study focuses on its additional role as an extracellular effector of lymphocyte cell death. It is well known that Tat induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in peri...

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Bibliographic Details
Published in:	Journal of virology Vol. 77; no. 12; p. 6700
Main Authors:	Yang, Yida, Tikhonov, Ilia, Ruckwardt, Tracy J, Djavani, Mahmoud, Zapata, Juan Carlos, Pauza, C David, Salvato, Maria S
Format:	Journal Article
Language:	English
Published:	United States 01.06.2003
Subjects:	Apoptosis Apoptosis Regulatory Proteins CD4-Positive T-Lymphocytes - physiology CD4-Positive T-Lymphocytes - virology Gene Products, tat - metabolism Gene Products, tat - pharmacology HIV-1 - physiology Humans Jurkat Cells Membrane Glycoproteins - drug effects Membrane Glycoproteins - metabolism Monocytes - drug effects Monocytes - metabolism tat Gene Products, Human Immunodeficiency Virus TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - metabolism U937 Cells Up-Regulation
ISSN:	0022-538X
Online Access:	Get more information
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