Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology

Ever since the “great oxidation event,” Earth’s cellular life forms had to cope with the danger of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering cellular metabolism circuits. Consequently, increasing ROS levels in the biosphere represented growing stress levels...

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Bibliographic Details
Published in:Frontiers in molecular biosciences Vol. 8; p. 671037
Main Authors: Fasnacht, Michel, Polacek, Norbert
Format: Journal Article
Language:English
Published: Frontiers Media S.A 10.05.2021
Subjects:
DNA damage
Molecular Biosciences
oxidative damage
oxidative stress
protein damage
RNA damage
ROS
ISSN:2296-889X, 2296-889X
Online Access:Get full text
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Summary:Ever since the “great oxidation event,” Earth’s cellular life forms had to cope with the danger of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering cellular metabolism circuits. Consequently, increasing ROS levels in the biosphere represented growing stress levels and thus shaped the evolution of species. Whether the ROS were produced endogenously or exogenously, different systems evolved to remove the ROS and repair the damage they inflicted. If ROS outweigh the cell’s capacity to remove the threat, we speak of oxidative stress. The injuries through oxidative stress in cells are diverse. This article reviews the damage oxidative stress imposes on the different steps of the central dogma of molecular biology in bacteria, focusing in particular on the RNA machines involved in transcription and translation.
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Edited by: Claudio Scazzocchio, Imperial College London, United Kingdom
This article was submitted to Protein and RNA Networks, a section of the journal Frontiers in Molecular Biosciences
Reviewed by: Esa Tyystjärvi, University of Turku, Finland
Sunny Sharma, Rutgers, The State University of New Jersey, United States
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2021.671037