Polyunsaturated Fatty Acids Level and Bone Mineral Density: A Two-Sample Mendelian Randomization Study
This Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD).BackgroundThis Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone...
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| Veröffentlicht in: | Frontiers in endocrinology (Lausanne) Jg. 13; S. 858851 |
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08.07.2022
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| Abstract | This Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD).BackgroundThis Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD).We conducted a two-sample MR analysis to figure out if there is any causal effect of PUFAs on BMD through the summary data from the genome-wide association study (GWAS). Relationships were evaluated through inverse variance weighted (IVW), MR-Egger, weighted median, and maximum likelihood methods. The MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test was performed to detect the horizontal pleiotropy.MethodsWe conducted a two-sample MR analysis to figure out if there is any causal effect of PUFAs on BMD through the summary data from the genome-wide association study (GWAS). Relationships were evaluated through inverse variance weighted (IVW), MR-Egger, weighted median, and maximum likelihood methods. The MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test was performed to detect the horizontal pleiotropy.Our findings revealed that omega-6 fatty acids were negatively related to the TB-BMD (beta-estimate: -0.0515; 95% confidence interval [CI]: -0.0911 to -0.0119; standard error [SE]: 0.0201; p-value: 0.0106). The reverse direction MR analysis showed that TB-BMD was linked to the omega-6 FAs (beta-estimate: -0.0699; 95% CI: -0.1304 to -0.0095; SE: 0.0308; p-value: 0.0265). No statistically significant correlations between PUFAs and BMD were observed after adjusting the interactions between metabolites.ResultsOur findings revealed that omega-6 fatty acids were negatively related to the TB-BMD (beta-estimate: -0.0515; 95% confidence interval [CI]: -0.0911 to -0.0119; standard error [SE]: 0.0201; p-value: 0.0106). The reverse direction MR analysis showed that TB-BMD was linked to the omega-6 FAs (beta-estimate: -0.0699; 95% CI: -0.1304 to -0.0095; SE: 0.0308; p-value: 0.0265). No statistically significant correlations between PUFAs and BMD were observed after adjusting the interactions between metabolites.This two-sample MR analyses produced strong and new genomic evidence that there was a causal relationship between omega-6 FAs and BMD. Further investigations are still required to elucidate the potential mechanism.ConclusionThis two-sample MR analyses produced strong and new genomic evidence that there was a causal relationship between omega-6 FAs and BMD. Further investigations are still required to elucidate the potential mechanism. |
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| AbstractList | BackgroundThis Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD).MethodsWe conducted a two-sample MR analysis to figure out if there is any causal effect of PUFAs on BMD through the summary data from the genome-wide association study (GWAS). Relationships were evaluated through inverse variance weighted (IVW), MR-Egger, weighted median, and maximum likelihood methods. The MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test was performed to detect the horizontal pleiotropy.ResultsOur findings revealed that omega-6 fatty acids were negatively related to the TB-BMD (beta-estimate: −0.0515; 95% confidence interval [CI]: −0.0911 to −0.0119; standard error [SE]: 0.0201; p-value: 0.0106). The reverse direction MR analysis showed that TB-BMD was linked to the omega-6 FAs (beta-estimate: −0.0699; 95% CI: −0.1304 to −0.0095; SE: 0.0308; p-value: 0.0265). No statistically significant correlations between PUFAs and BMD were observed after adjusting the interactions between metabolites.ConclusionThis two-sample MR analyses produced strong and new genomic evidence that there was a causal relationship between omega-6 FAs and BMD. Further investigations are still required to elucidate the potential mechanism. This Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD).BackgroundThis Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD).We conducted a two-sample MR analysis to figure out if there is any causal effect of PUFAs on BMD through the summary data from the genome-wide association study (GWAS). Relationships were evaluated through inverse variance weighted (IVW), MR-Egger, weighted median, and maximum likelihood methods. The MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test was performed to detect the horizontal pleiotropy.MethodsWe conducted a two-sample MR analysis to figure out if there is any causal effect of PUFAs on BMD through the summary data from the genome-wide association study (GWAS). Relationships were evaluated through inverse variance weighted (IVW), MR-Egger, weighted median, and maximum likelihood methods. The MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test was performed to detect the horizontal pleiotropy.Our findings revealed that omega-6 fatty acids were negatively related to the TB-BMD (beta-estimate: -0.0515; 95% confidence interval [CI]: -0.0911 to -0.0119; standard error [SE]: 0.0201; p-value: 0.0106). The reverse direction MR analysis showed that TB-BMD was linked to the omega-6 FAs (beta-estimate: -0.0699; 95% CI: -0.1304 to -0.0095; SE: 0.0308; p-value: 0.0265). No statistically significant correlations between PUFAs and BMD were observed after adjusting the interactions between metabolites.ResultsOur findings revealed that omega-6 fatty acids were negatively related to the TB-BMD (beta-estimate: -0.0515; 95% confidence interval [CI]: -0.0911 to -0.0119; standard error [SE]: 0.0201; p-value: 0.0106). The reverse direction MR analysis showed that TB-BMD was linked to the omega-6 FAs (beta-estimate: -0.0699; 95% CI: -0.1304 to -0.0095; SE: 0.0308; p-value: 0.0265). No statistically significant correlations between PUFAs and BMD were observed after adjusting the interactions between metabolites.This two-sample MR analyses produced strong and new genomic evidence that there was a causal relationship between omega-6 FAs and BMD. Further investigations are still required to elucidate the potential mechanism.ConclusionThis two-sample MR analyses produced strong and new genomic evidence that there was a causal relationship between omega-6 FAs and BMD. Further investigations are still required to elucidate the potential mechanism. |
| Author | Huang, Tianji Zhao, Zenghui Luo, Xiaoji Zhang, Chao Zhou, Nian Liang, Hao Wang, Lin |
| AuthorAffiliation | 1 Department of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China 2 Orthopedic Laboratory of Chongqing Medical University , Chongqing , China |
| AuthorAffiliation_xml | – name: 1 Department of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China – name: 2 Orthopedic Laboratory of Chongqing Medical University , Chongqing , China |
| Author_xml | – sequence: 1 givenname: Lin surname: Wang fullname: Wang, Lin – sequence: 2 givenname: Chao surname: Zhang fullname: Zhang, Chao – sequence: 3 givenname: Hao surname: Liang fullname: Liang, Hao – sequence: 4 givenname: Nian surname: Zhou fullname: Zhou, Nian – sequence: 5 givenname: Tianji surname: Huang fullname: Huang, Tianji – sequence: 6 givenname: Zenghui surname: Zhao fullname: Zhao, Zenghui – sequence: 7 givenname: Xiaoji surname: Luo fullname: Luo, Xiaoji |
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| Cites_doi | 10.3390/nu13051454 10.1002/gepi.21758 10.1111/cpr.12735 10.1093/bioinformatics/btw373 10.1016/j.jnutbio.2005.05.012 10.3945/ajcn.114.087502 10.1002/jcsm.12144 10.1007/s11914-013-0149-0 10.7326/aitc201708010 10.1007/s00198-012-1903-3 10.1177/0962280215597579 10.1016/s0140-6736(18)32112-3 10.1001/JAMA.287.1.47 10.1038/nature14878 10.1038/nrg3228 10.7554/eLife.34408 10.1371/journal.pgen.1007081 10.1038/ejcn.2011.188 10.1002/jbmr.87 10.3390/nu12113494 10.1007/s00223-019-00584-3 10.1186/1476-069x-12-54 10.1002/jbmr.1581 10.1093/aje/kwt084 10.2147/cia.S100566 10.1007/s11357-009-9122-3 10.1002/gepi.21965 10.1007/s00223-004-0108-y 10.1016/j.plipres.2015.03.001 10.1001/JAMA.2017.17219 10.1371/journal.pmed.1001779 10.1093/bioinformatics/btz469 10.1002/jbmr.1772 10.1038/nature09534 10.1038/s41588-018-0099-7 10.1016/j.ajhg.2017.12.005 10.1093/ije/dyw220 10.1038/s41588-018-0302-x 10.1093/ije/dyr036 10.1007/s10654-017-0255-x 10.1038/s41574-019-0282-7 10.1016/j.bone.2014.07.024 10.1002/jbmr.5650090802 10.7554/eLife.63033 10.3945/ajcn.2010.29955 10.1002/sim.3034 10.1038/nrrheum.2009.260 10.3945/an.115.009472 10.1001/JAMA.293.18.2257 10.3390/nu10030309 10.1016/j.bone.2005.08.003 10.1359/jbmr.061113 10.1016/s0952-3278(03)00067-x |
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| Copyright | Copyright © 2022 Wang, Zhang, Liang, Zhou, Huang, Zhao and Luo. Copyright © 2022 Wang, Zhang, Liang, Zhou, Huang, Zhao and Luo 2022 Wang, Zhang, Liang, Zhou, Huang, Zhao and Luo |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Alberto Falchetti, Italian Auxological Institute (IRCCS), Italy Reviewed by: Maria Lucia Fleiuss Farias, Federal University of Rio de Janeiro, Brazil; Ping Zeng, Xuzhou Medical University, China This article was submitted to Bone Research, a section of the journal Frontiers in Endocrinology |
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| Snippet | This Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone mineral density... BackgroundThis Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone mineral density... |
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| SubjectTerms | bone mineral density—BMD Endocrinology mendelian randomization omega - 3 fatty acids osteoporosis polyunsaturated fatty acids - PUFA |
| Title | Polyunsaturated Fatty Acids Level and Bone Mineral Density: A Two-Sample Mendelian Randomization Study |
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