A Novel Fragmentation Sensitivity Index Determines the Susceptibility of Red Blood Cells to Mechanical Trauma

Supraphysiological shear stresses (SSs) induce irreversible impairments of red blood cell (RBC) deformability, overstretching of RBC membrane, or fragmentation of RBCs that causes free hemoglobin to be released into plasma, which may lead to anemia. The magnitude and exposure tisme of the SSs are tw...

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Bibliographic Details
Published in:	Frontiers in physiology Vol. 12; p. 714157
Main Authors:	Ugurel, Elif, Goksel, Evrim, Goktas, Polat, Cilek, Neslihan, Atar, Dila, Yalcin, Ozlem
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 25.08.2021
Subjects:	fragmentaton sensitivity index mechanical risk sensitivity metabolic depletion oxidative stress Physiology red blood cell fragmentation supra-physiological shear stress
ISSN:	1664-042X, 1664-042X
Online Access:	Get full text
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