Streptomyces: The biofactory of secondary metabolites

Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial genus in the environments with prolific capability to produce diverse and valuable natural products with significant biological act...

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Published in:Frontiers in microbiology Vol. 13; p. 968053
Main Authors: Alam, Khorshed, Mazumder, Arpita, Sikdar, Suranjana, Zhao, Yi-Ming, Hao, Jinfang, Song, Chaoyi, Wang, Yanyan, Sarkar, Rajib, Islam, Saiful, Zhang, Youming, Li, Aiying
Format: Journal Article
Language:English
Published: Frontiers Media S.A 29.09.2022
Subjects:
bioactive compounds
genome mining
metagenomics
Microbiology
natural products
Streptomyces
ISSN:1664-302X, 1664-302X
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Abstract Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial genus in the environments with prolific capability to produce diverse and valuable natural products with significant biological activities in medicine, environments, food industries, and agronomy sectors. However, many natural products remain unexplored among Streptomyces . It is exigent to develop novel antibiotics, agrochemicals, anticancer medicines, etc., due to the fast growth in resistance to antibiotics, cancer chemotherapeutics, and pesticides. This review article focused the natural products secreted by Streptomyces and their function and importance in curing diseases and agriculture. Moreover, it discussed genomic-driven drug discovery strategies and also gave a future perspective for drug development from the Streptomyces .
AbstractList Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial genus in the environments with prolific capability to produce diverse and valuable natural products with significant biological activities in medicine, environments, food industries, and agronomy sectors. However, many natural products remain unexplored among Streptomyces. It is exigent to develop novel antibiotics, agrochemicals, anticancer medicines, etc., due to the fast growth in resistance to antibiotics, cancer chemotherapeutics, and pesticides. This review article focused the natural products secreted by Streptomyces and their function and importance in curing diseases and agriculture. Moreover, it discussed genomic-driven drug discovery strategies and also gave a future perspective for drug development from the Streptomyces.Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial genus in the environments with prolific capability to produce diverse and valuable natural products with significant biological activities in medicine, environments, food industries, and agronomy sectors. However, many natural products remain unexplored among Streptomyces. It is exigent to develop novel antibiotics, agrochemicals, anticancer medicines, etc., due to the fast growth in resistance to antibiotics, cancer chemotherapeutics, and pesticides. This review article focused the natural products secreted by Streptomyces and their function and importance in curing diseases and agriculture. Moreover, it discussed genomic-driven drug discovery strategies and also gave a future perspective for drug development from the Streptomyces.
Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial genus in the environments with prolific capability to produce diverse and valuable natural products with significant biological activities in medicine, environments, food industries, and agronomy sectors. However, many natural products remain unexplored among Streptomyces . It is exigent to develop novel antibiotics, agrochemicals, anticancer medicines, etc., due to the fast growth in resistance to antibiotics, cancer chemotherapeutics, and pesticides. This review article focused the natural products secreted by Streptomyces and their function and importance in curing diseases and agriculture. Moreover, it discussed genomic-driven drug discovery strategies and also gave a future perspective for drug development from the Streptomyces .
Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial genus in the environments with prolific capability to produce diverse and valuable natural products with significant biological activities in medicine, environments, food industries, and agronomy sectors. However, many natural products remain unexplored among Streptomyces. It is exigent to develop novel antibiotics, agrochemicals, anticancer medicines, etc., due to the fast growth in resistance to antibiotics, cancer chemotherapeutics, and pesticides. This review article focused the natural products secreted by Streptomyces and their function and importance in curing diseases and agriculture. Moreover, it discussed genomic-driven drug discovery strategies and also gave a future perspective for drug development from the Streptomyces.
Author Sikdar, Suranjana
Zhang, Youming
Wang, Yanyan
Alam, Khorshed
Islam, Saiful
Li, Aiying
Zhao, Yi-Ming
Mazumder, Arpita
Song, Chaoyi
Hao, Jinfang
Sarkar, Rajib
AuthorAffiliation 3 Industrial Microbiology Research Division, BCSIR Chattogram Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR) , Chattogram , Bangladesh
2 Department of Microbiology, University of Chittagong , Chittagong , Bangladesh
1 Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University , Qingdao , China
4 Chinese Academy of Sciences (CAS) Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences , Shenzhen , China
AuthorAffiliation_xml – name: 4 Chinese Academy of Sciences (CAS) Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences , Shenzhen , China
– name: 3 Industrial Microbiology Research Division, BCSIR Chattogram Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR) , Chattogram , Bangladesh
– name: 1 Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University , Qingdao , China
– name: 2 Department of Microbiology, University of Chittagong , Chittagong , Bangladesh
Author_xml – sequence: 1
  givenname: Khorshed
  surname: Alam
  fullname: Alam, Khorshed
– sequence: 2
  givenname: Arpita
  surname: Mazumder
  fullname: Mazumder, Arpita
– sequence: 3
  givenname: Suranjana
  surname: Sikdar
  fullname: Sikdar, Suranjana
– sequence: 4
  givenname: Yi-Ming
  surname: Zhao
  fullname: Zhao, Yi-Ming
– sequence: 5
  givenname: Jinfang
  surname: Hao
  fullname: Hao, Jinfang
– sequence: 6
  givenname: Chaoyi
  surname: Song
  fullname: Song, Chaoyi
– sequence: 7
  givenname: Yanyan
  surname: Wang
  fullname: Wang, Yanyan
– sequence: 8
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  surname: Sarkar
  fullname: Sarkar, Rajib
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  surname: Islam
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– sequence: 10
  givenname: Youming
  surname: Zhang
  fullname: Zhang, Youming
– sequence: 11
  givenname: Aiying
  surname: Li
  fullname: Li, Aiying
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Reviewed by: Noraziah Binti Mohamad Zin, National University of Malaysia, Malaysia; Anil Kumar Pinnaka, Institute of Microbial Technology (CSIR), India
Edited by: Crtomir Podlipnik, University of Ljubljana, Slovenia
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Snippet Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous...
Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous...
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SubjectTerms bioactive compounds
genome mining
metagenomics
Microbiology
natural products
Streptomyces
Title Streptomyces: The biofactory of secondary metabolites
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https://pubmed.ncbi.nlm.nih.gov/PMC9558229
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