Streptomyces: The biofactory of secondary metabolites

Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial genus in the environments with prolific capability to produce diverse and valuable natural products with significant biological act...

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Bibliographic Details
Published in:Frontiers in microbiology Vol. 13; p. 968053
Main Authors: Alam, Khorshed, Mazumder, Arpita, Sikdar, Suranjana, Zhao, Yi-Ming, Hao, Jinfang, Song, Chaoyi, Wang, Yanyan, Sarkar, Rajib, Islam, Saiful, Zhang, Youming, Li, Aiying
Format: Journal Article
Language:English
Published: Frontiers Media S.A 29.09.2022
Subjects:
bioactive compounds
genome mining
metagenomics
Microbiology
natural products
Streptomyces
ISSN:1664-302X, 1664-302X
Online Access:Get full text
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Summary:Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial genus in the environments with prolific capability to produce diverse and valuable natural products with significant biological activities in medicine, environments, food industries, and agronomy sectors. However, many natural products remain unexplored among Streptomyces . It is exigent to develop novel antibiotics, agrochemicals, anticancer medicines, etc., due to the fast growth in resistance to antibiotics, cancer chemotherapeutics, and pesticides. This review article focused the natural products secreted by Streptomyces and their function and importance in curing diseases and agriculture. Moreover, it discussed genomic-driven drug discovery strategies and also gave a future perspective for drug development from the Streptomyces .
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Reviewed by: Noraziah Binti Mohamad Zin, National University of Malaysia, Malaysia; Anil Kumar Pinnaka, Institute of Microbial Technology (CSIR), India
Edited by: Crtomir Podlipnik, University of Ljubljana, Slovenia
This article was submitted to Antimicrobials, Resistance and Chemotherapy, a section of the journal Frontiers in Microbiology
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2022.968053