Upregulation of long non-coding RNA MEG3 in type 2 diabetes mellitus complicated with vascular disease: a case–control study

Previous studies have indicated that long non-coding RNAs (lncRNAs) were closely related to diabetes. In this study, we aimed to explore the possible role and mechanism of lncRNA MEG3 in the occurrence and development of type 2 diabetes mellitus (T2DM) and its vascular complications. A case–control...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Molecular and cellular biochemistry Ročník 473; číslo 1-2; s. 93 - 99
Hlavní autori:	Chang, Wei-wei, Zhang, Liu, Yao, Xin-ming, Chen, Yan, Zhu, Li-jun, Fang, Zheng-mei, Zhao, Ying, Yao, Ying-shui, Jin, Yue-long
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Springer US 01.10.2020 Springer Springer Nature B.V
Predmet:	Aged Analysis Biochemistry Biomedical and Life Sciences Blood circulation disorders Blood Glucose - metabolism Cardiology Case studies Case-Control Studies Development and progression Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes therapy Diabetic Angiopathies - blood Disease control Ethylenediaminetetraacetic acid Female Glycosylated hemoglobin Hemoglobin Humans Leukocytes (mononuclear) Life Sciences Male Medical Biochemistry Medical research Medicine, Experimental MicroRNAs - blood Middle Aged Non-coding RNA Oncology Pathogenesis Peripheral blood mononuclear cells Polymerase chain reaction Reverse Transcriptase Polymerase Chain Reaction RNA RNA, Long Noncoding - biosynthesis Type 2 diabetes Up-Regulation Vascular diseases MEG3 Vascular complications Diabetes mellitus Long non-coding RNA
ISSN:	0300-8177, 1573-4919, 1573-4919
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	Previous studies have indicated that long non-coding RNAs (lncRNAs) were closely related to diabetes. In this study, we aimed to explore the possible role and mechanism of lncRNA MEG3 in the occurrence and development of type 2 diabetes mellitus (T2DM) and its vascular complications. A case–control study involving 115 subjects was conducted, including 53 T2DM patients (37 patients with vascular complication and 16 patients without vascular complications) and 62 healthy subjects. We performed real-time polymerase chain reaction (RT-PCR) analysis of the lncRNA MEG3 and miR-146a levels in peripheral blood mononuclear cells (PBMCs) in the 115 samples. We found that the expression of lncRNA MEG3 was upregulated in the T2DM patients with vascular complication (DC group) compared with T2DM patients without vascular complication (D group) ( P < 0.05) and the control group ( P < 0.01). miR-146a levels in DC group were significantly lower compared with control group. There was a significant positive correlation between the expression of lncRNA MEG3 and glucose (GLU) ( r = 0.301, P = 0.0011) and hemoglobin A1C (HbA1c) ( r = 0.477, P = 0.0006). Our study suggests MEG3 may play as an important role in progression of diabetes-related vascular complications, contributing to a novel understanding of pathogenesis and prognosis for diabetes and its complications.
AbstractList	Previous studies have indicated that long non-coding RNAs (lncRNAs) were closely related to diabetes. In this study, we aimed to explore the possible role and mechanism of lncRNA MEG3 in the occurrence and development of type 2 diabetes mellitus (T2DM) and its vascular complications. A case-control study involving 115 subjects was conducted, including 53 T2DM patients (37 patients with vascular complication and 16 patients without vascular complications) and 62 healthy subjects. We performed real-time polymerase chain reaction (RT-PCR) analysis of the lncRNA MEG3 and miR-146a levels in peripheral blood mononuclear cells (PBMCs) in the 115 samples. We found that the expression of lncRNA MEG3 was upregulated in the T2DM patients with vascular complication (DC group) compared with T2DM patients without vascular complication (D group) (P < 0.05) and the control group (P < 0.01). miR-146a levels in DC group were significantly lower compared with control group. There was a significant positive correlation between the expression of lncRNA MEG3 and glucose (GLU) (r = 0.301, P = 0.0011) and hemoglobin A1C (HbA1c) (r = 0.477, P = 0.0006). Our study suggests MEG3 may play as an important role in progression of diabetes-related vascular complications, contributing to a novel understanding of pathogenesis and prognosis for diabetes and its complications.Previous studies have indicated that long non-coding RNAs (lncRNAs) were closely related to diabetes. In this study, we aimed to explore the possible role and mechanism of lncRNA MEG3 in the occurrence and development of type 2 diabetes mellitus (T2DM) and its vascular complications. A case-control study involving 115 subjects was conducted, including 53 T2DM patients (37 patients with vascular complication and 16 patients without vascular complications) and 62 healthy subjects. We performed real-time polymerase chain reaction (RT-PCR) analysis of the lncRNA MEG3 and miR-146a levels in peripheral blood mononuclear cells (PBMCs) in the 115 samples. We found that the expression of lncRNA MEG3 was upregulated in the T2DM patients with vascular complication (DC group) compared with T2DM patients without vascular complication (D group) (P < 0.05) and the control group (P < 0.01). miR-146a levels in DC group were significantly lower compared with control group. There was a significant positive correlation between the expression of lncRNA MEG3 and glucose (GLU) (r = 0.301, P = 0.0011) and hemoglobin A1C (HbA1c) (r = 0.477, P = 0.0006). Our study suggests MEG3 may play as an important role in progression of diabetes-related vascular complications, contributing to a novel understanding of pathogenesis and prognosis for diabetes and its complications. Previous studies have indicated that long non-coding RNAs (lncRNAs) were closely related to diabetes. In this study, we aimed to explore the possible role and mechanism of lncRNA MEG3 in the occurrence and development of type 2 diabetes mellitus (T2DM) and its vascular complications. A case-control study involving 115 subjects was conducted, including 53 T2DM patients (37 patients with vascular complication and 16 patients without vascular complications) and 62 healthy subjects. We performed real-time polymerase chain reaction (RT-PCR) analysis of the lncRNA MEG3 and miR-146a levels in peripheral blood mononuclear cells (PBMCs) in the 115 samples. We found that the expression of lncRNA MEG3 was upregulated in the T2DM patients with vascular complication (DC group) compared with T2DM patients without vascular complication (D group) (P < 0.05) and the control group (P < 0.01). miR-146a levels in DC group were significantly lower compared with control group. There was a significant positive correlation between the expression of lncRNA MEG3 and glucose (GLU) (r = 0.301, P = 0.0011) and hemoglobin A1C (HbA1c) (r = 0.477, P = 0.0006). Our study suggests MEG3 may play as an important role in progression of diabetes-related vascular complications, contributing to a novel understanding of pathogenesis and prognosis for diabetes and its complications. Previous studies have indicated that long non-coding RNAs (lncRNAs) were closely related to diabetes. In this study, we aimed to explore the possible role and mechanism of lncRNA MEG3 in the occurrence and development of type 2 diabetes mellitus (T2DM) and its vascular complications. A case–control study involving 115 subjects was conducted, including 53 T2DM patients (37 patients with vascular complication and 16 patients without vascular complications) and 62 healthy subjects. We performed real-time polymerase chain reaction (RT-PCR) analysis of the lncRNA MEG3 and miR-146a levels in peripheral blood mononuclear cells (PBMCs) in the 115 samples. We found that the expression of lncRNA MEG3 was upregulated in the T2DM patients with vascular complication (DC group) compared with T2DM patients without vascular complication (D group) ( P < 0.05) and the control group ( P < 0.01). miR-146a levels in DC group were significantly lower compared with control group. There was a significant positive correlation between the expression of lncRNA MEG3 and glucose (GLU) ( r = 0.301, P = 0.0011) and hemoglobin A1C (HbA1c) ( r = 0.477, P = 0.0006). Our study suggests MEG3 may play as an important role in progression of diabetes-related vascular complications, contributing to a novel understanding of pathogenesis and prognosis for diabetes and its complications.
Audience	Academic
Author	Zhu, Li-jun Chang, Wei-wei Zhang, Liu Jin, Yue-long Yao, Ying-shui Yao, Xin-ming Fang, Zheng-mei Chen, Yan Zhao, Ying
Author_xml	– sequence: 1 givenname: Wei-wei surname: Chang fullname: Chang, Wei-wei organization: Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College – sequence: 2 givenname: Liu surname: Zhang fullname: Zhang, Liu organization: Department of Hospital Infection Management Office, Wuhu Hospital of Traditional Chinese Medicine – sequence: 3 givenname: Xin-ming surname: Yao fullname: Yao, Xin-ming organization: Department of Endocrine, The First Affiliated Hospital of Wannan Medical College – sequence: 4 givenname: Yan surname: Chen fullname: Chen, Yan organization: Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College – sequence: 5 givenname: Li-jun surname: Zhu fullname: Zhu, Li-jun organization: Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College – sequence: 6 givenname: Zheng-mei surname: Fang fullname: Fang, Zheng-mei organization: Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College – sequence: 7 givenname: Ying surname: Zhao fullname: Zhao, Ying organization: Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College – sequence: 8 givenname: Ying-shui orcidid: 0000-0001-6864-5145 surname: Yao fullname: Yao, Ying-shui email: yingshuiyao@126.com organization: Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College – sequence: 9 givenname: Yue-long surname: Jin fullname: Jin, Yue-long email: 94017416@qq.com organization: Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32594338$$D View this record in MEDLINE/PubMed
BookMark	eNp9ks9u1DAQxi1URLeFF-CALHHhkuI_ycbhtqpKQSogIXq2HHuyuEriYDvQPcE78AI8C4_CkzDbbVVRocqyxrJ-3zf2zByQvTGMQMhTzo44Y_XLxDnjrGACt1R4unxAFryqZVE2vNkjCyYZKxSv631ykNIFQ5px_ojsS1E1pZRqQb6fTxHWc2-yDyMNHe3DuKaYqLDBeTx-fL-i705OJfXj7195MwEV1HnTQoZEB-h7n-dEbRim3luTwdFvPn-mX02y6BqRTWASvKKGWox_fvy0Ycwx9DTl2W0ek4ed6RM8uY6H5Pz1yafjN8XZh9O3x6uzwpalyEUroeL4Rem4kG0puBCMV24plKqWIETHwTnBms5CA1yxupKyAsWcqDvXdkt5SF7sfKcYvsyQsh58svh8M0KYkxYlV7Vo6maLPr-DXoQ5jvg6pEqsuRAVv6XWpgftxy7kaOzWVK-WsmJcqIYhdfQfCpeDwWMhoPN4_4_g2XXyuR3A6Sn6wcSNvukYAmoH2BhSitBp6_NV99DZ95ozvR0OvRsOjcOhr4ZDX6JU3JHeuN8rkjtRQnhcQ7ytxj2qvywbyyk
CitedBy_id	crossref_primary_10_1038_s41435_021_00154_4 crossref_primary_10_1007_s40200_025_01591_y crossref_primary_10_1186_s12933_024_02292_1 crossref_primary_10_1038_s41467_023_42560_4 crossref_primary_10_1155_2023_3720602 crossref_primary_10_1186_s12933_024_02327_7 crossref_primary_10_4081_itjm_2024_1830 crossref_primary_10_1007_s11033_022_08122_5 crossref_primary_10_3390_biomedicines12061322 crossref_primary_10_3390_nu13082821 crossref_primary_10_1186_s13098_021_00719_3 crossref_primary_10_3389_fgene_2023_1132884
Cites_doi	10.1536/ihj.18-195 10.1002/jcp.25175 10.1161/CIRCULATIONAHA.117.029004 10.18632/aging.102011 10.1038/s41591-019-0415-5 10.1016/j.bbrc.2015.11.048 10.1016/j.cardfail.2019.05.007 10.1126/science.1240925 10.1161/CIRCRESAHA.118.313207 10.1080/10717544.2018.1425774 10.2337/dc20-S002 10.1042/CS20171459 10.1016/j.cmet.2013.11.016 10.1007/s12035-016-0270-z 10.1046/j.1365-2443.2000.00320.x 10.1038/ng.493 10.1038/leu.2017.116 10.1016/j.gene.2018.07.002 10.1097/MOL.0b013e32830f47cd 10.1016/j.canlet.2018.01.036 10.1006/meth.2001.1262 10.1161/CIRCULATIONAHA.117.029015 10.1172/JCI125985 10.1007/s11010-019-03681-x 10.1093/bioinformatics/btx672 10.1038/nrcardio.2017.139 10.1016/j.diabres.2018.02.023 10.3390/genes8080207 10.1016/j.ebiom.2018.03.032
ContentType	Journal Article
Copyright	Springer Science+Business Media, LLC, part of Springer Nature 2020 COPYRIGHT 2020 Springer Springer Science+Business Media, LLC, part of Springer Nature 2020.
Copyright_xml	– notice: Springer Science+Business Media, LLC, part of Springer Nature 2020 – notice: COPYRIGHT 2020 Springer – notice: Springer Science+Business Media, LLC, part of Springer Nature 2020.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7T5 7T7 7TK 7TM 7TO 7U9 7X7 7XB 88A 88E 88I 8AO 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M2P M7N M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI Q9U RC3 7X8
DOI	10.1007/s11010-020-03810-x
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central Basic Genetics Abstracts MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Central Basic ProQuest Science Journals ProQuest SciTech Collection ProQuest Medical Library Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic ProQuest Central Student MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Chemistry Biology
EISSN	1573-4919
EndPage	99
ExternalDocumentID	A635012890 32594338 10_1007_s11010_020_03810_x
Genre	Journal Article
GrantInformation_xml	– fundername: the National Natural Science Foundation of China (CN) grantid: 81441127
GroupedDBID	--- -4W -56 -5G -BR -EM -Y2 -~C -~X .55 .86 .GJ .VR 06C 06D 0R~ 0VY 123 199 1N0 1SB 2.D 203 28- 29M 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 3SX 3V. 4.4 406 408 409 40D 40E 53G 5QI 5RE 5VS 67N 67Z 6NX 78A 7X7 88A 88E 88I 8AO 8CJ 8FE 8FH 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X A8Z AAAVM AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABBBX ABBXA ABDZT ABECU ABFTV ABHLI ABHQN ABJNI ABJOX ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABQBU ABQSL ABSXP ABTEG ABTHY ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACAOD ACBXY ACDTI ACGFS ACGOD ACHSB ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACREN ACZOJ ADBBV ADHHG ADHIR ADIMF ADINQ ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADYOE ADYPR ADZKW AEBTG AEFIE AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEUYN AEVLU AEXYK AFBBN AFEXP AFFNX AFGCZ AFKRA AFLOW AFQWF AFRAH AFWTZ AFYQB AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMTXH AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN AZQEC B-. BA0 BBNVY BBWZM BDATZ BENPR BGNMA BHPHI BPHCQ BSONS BVXVI CAG CCPQU COF CS3 CSCUP D1J DDRTE DL5 DNIVK DPUIP DU5 DWQXO EBD EBLON EBS EIOEI EJD EMOBN EN4 EPAXT ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNUQQ GNWQR GQ6 GQ7 GQ8 GXS H13 HCIFZ HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IAG IAO IH2 IHE IHR IJ- IKXTQ INH INR ITC ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH LAK LK8 LLZTM M0L M1P M2P M4Y M7P MA- MVM N2Q N9A NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 PF0 PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RIG RNI RNS ROL RPX RRX RSV RZC RZE RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SBY SCLPG SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZN T13 T16 TEORI TSG TSK TSV TUC TUS U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WH7 WIP WJK WK6 WK8 X7M YLTOR Z45 Z7U Z7V Z7W Z82 Z83 Z87 Z8O Z8P Z8Q Z8V Z8W Z91 ZGI ZMTXR ZOVNA ~EX ~KM AAPKM AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC ADHKG AEZWR AFDZB AFFHD AFHIU AFOHR AGQPQ AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7QL 7QP 7T5 7T7 7TK 7TM 7TO 7U9 7XB 8FD 8FK C1K ESTFP FR3 H94 K9. M7N P64 PKEHL PQEST PQUKI Q9U RC3 7X8 PUEGO
ID	FETCH-LOGICAL-c442t-b3e518103d123b42122015d628856e22f1edd209fce9e18075335e80d27fdbf63
IEDL.DBID	M7P
ISICitedReferencesCount	14
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000544226500002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0300-8177 1573-4919
IngestDate	Mon Sep 08 13:37:16 EDT 2025 Tue Nov 04 22:33:21 EST 2025 Sat Nov 29 13:13:13 EST 2025 Sat Nov 29 10:07:24 EST 2025 Mon Jul 21 05:59:28 EDT 2025 Tue Nov 18 22:29:28 EST 2025 Sat Nov 29 03:38:56 EST 2025 Fri Feb 21 02:39:09 EST 2025
IsPeerReviewed	true
IsScholarly	true
Issue	1-2
Keywords	MEG3 Vascular complications Diabetes mellitus Long non-coding RNA
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c442t-b3e518103d123b42122015d628856e22f1edd209fce9e18075335e80d27fdbf63
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0001-6864-5145
PMID	32594338
PQID	2441102251
PQPubID	54196
PageCount	7
ParticipantIDs	proquest_miscellaneous_2418729796 proquest_journals_2441102251 gale_infotracmisc_A635012890 gale_infotracacademiconefile_A635012890 pubmed_primary_32594338 crossref_citationtrail_10_1007_s11010_020_03810_x crossref_primary_10_1007_s11010_020_03810_x springer_journals_10_1007_s11010_020_03810_x
PublicationCentury	2000
PublicationDate	20201000 2020-10-00 2020-Oct 20201001
PublicationDateYYYYMMDD	2020-10-01
PublicationDate_xml	– month: 10 year: 2020 text: 20201000
PublicationDecade	2020
PublicationPlace	New York
PublicationPlace_xml	– name: New York – name: Netherlands
PublicationSubtitle	An International Journal for Chemical Biology in Health and Disease
PublicationTitle	Molecular and cellular biochemistry
PublicationTitleAbbrev	Mol Cell Biochem
PublicationTitleAlternate	Mol Cell Biochem
PublicationYear	2020
Publisher	Springer US Springer Springer Nature B.V
Publisher_xml	– name: Springer US – name: Springer – name: Springer Nature B.V
References	You, Wang, Yin (CR27) 2016; 231 You, Wang, Yin, WangLT, Yuan, De (CR35) 2016; 231 Zhu, Chen, Gao, Ta, Zhang, Cai, Zhao, Liu, Zheng (CR12) 2018; 30 (CR20) 2020; 43 Wallace, Smyth, Maisuria-Armer, Walker, Todd, Clayton (CR26) 2010; 42 Wang (CR34) 2018 Morin (CR4) 2019; 129 Jha, Ho, Dan, Jandeleit-Dahm (CR22) 2018; 132 Cremer, Michalik, Fischer, Pfisterer, Jaé, Winter, Boonet (CR13) 2019; 139 Li, Wan, Liu, Xu, Wang, Su, Zhang, Zhang, Liu, Lei, Zhang (CR3) 2018; 418 Miyoshi, Wagatsuma, Wakana, Shiroishi, Nomura, Aisaka, Kohda, Surani, Kaneko-Ishino, Ishino (CR10) 2000; 5 Tao, Rui, Wang (CR8) 2018; 25 Liu, Li, Zhang, Hu (CR30) 2017; 54 Carpenter, Aiello, Atianand (CR7) 2013; 341 Bai, Zhang, Su, Pu, Li (CR14) 2019; 60 Dunlay, Givertz, Aguilar (CR2) 2019 Leti, DiStefano (CR25) 2017; 8 Li, Zhang, Zhang, Wang (CR17) 2020 Ghaedi, Zare, Omrani, Doustimotlagh, Meshkani, Alipoor, Alipoor (CR16) 2018; 675 Kameswaran, Bramswig, McKenna (CR15) 2014; 19 Shan, Liu, Liu, Chen, Dong, Zhang (CR9) 2017; 136 Zhu, Wu, Zhou (CR33) 2016; 469 Huang, Chan, You (CR31) 2018; 34 Kim, Uriel, Burkhoff (CR5) 2018; 15 Wang (CR28) 2018 Das, Zhang, Senapati, Amaram, Reddy, Stapleton (CR24) 2018; 123 Zha, Qu, Tang (CR29) 2019; 11 Livak, Schmittgen (CR19) 2001; 25 Lyu, Lou, Yang, Feng, Hao, Huang (CR11) 2017; 31 Nilsson, Bengtsson, Fredrikson, Björkbacka (CR23) 2008; 19 Gao (CR18) 2018; 15 Niewczas, Pavkov, Skupien (CR6) 2019; 25 Li, Mao, Huang (CR21) 2019; 38 Yan, Wang, Yin (CR32) 2019; 27 Cho, Shaw, Karuranga, Huang, da Rocha, Ohlrogge, Malanda (CR1) 2018; 138 F Zha (3810_CR29) 2019; 11 GH Kim (3810_CR5) 2018; 15 JC Jha (3810_CR22) 2018; 132 Y Zhu (3810_CR12) 2018; 30 American Diabetes Association (3810_CR20) 2020; 43 J Liu (3810_CR30) 2017; 54 S Cremer (3810_CR13) 2019; 139 NH Cho (3810_CR1) 2018; 138 Y Li (3810_CR21) 2019; 38 YA Huang (3810_CR31) 2018; 34 S Das (3810_CR24) 2018; 123 N Miyoshi (3810_CR10) 2000; 5 Y Lyu (3810_CR11) 2017; 31 SM Dunlay (3810_CR2) 2019 YF Gao (3810_CR18) 2018; 15 C Wallace (3810_CR26) 2010; 42 LH You (3810_CR35) 2016; 231 H Ghaedi (3810_CR16) 2018; 675 ZQ Wang (3810_CR28) 2018 Y Bai (3810_CR14) 2019; 60 S-C Tao (3810_CR8) 2018; 25 F Leti (3810_CR25) 2017; 8 YX Yan (3810_CR32) 2019; 27 S Carpenter (3810_CR7) 2013; 341 Y Li (3810_CR17) 2020 X Zhu (3810_CR33) 2016; 469 MA Niewczas (3810_CR6) 2019; 25 K Shan (3810_CR9) 2017; 136 V Kameswaran (3810_CR15) 2014; 19 WH Wang (3810_CR34) 2018 PJ Morin (3810_CR4) 2019; 129 J Nilsson (3810_CR23) 2008; 19 KJ Livak (3810_CR19) 2001; 25 L You (3810_CR27) 2016; 231 C Li (3810_CR3) 2018; 418
References_xml	– volume: 60 start-page: 444 issue: 2 year: 2019 end-page: 450 ident: CR14 article-title: Modulation of the proliferation/apoptosis balance of vascular smooth muscle cells in atherosclerosis by lncRNA-MEG3 via regulation of miR-26a/Smad1 Axis publication-title: Int Heart J doi: 10.1536/ihj.18-195 – volume: 38 start-page: 69 issue: 10 year: 2019 end-page: 71 ident: CR21 article-title: Analysis on inpatient cost structure and influencing factors of diabetes patients from the perspective of Universal Medical Insurance publication-title: Chin Health Econ – year: 2018 ident: CR34 publication-title: Differential expression of lncRNA MEG3 in patients with different glycometabolism and analysis of related functions – volume: 231 start-page: 852 year: 2016 end-page: 862 ident: CR35 article-title: Downregulation of long noncoding RNA meg3 affects insulin synthesis and secretion in mouse pancreatic beta cells publication-title: J Cell Physiol doi: 10.1002/jcp.25175 – volume: 136 start-page: 1629 issue: 17 year: 2017 end-page: 1642 ident: CR9 article-title: Circular noncoding RNA HIPK3 mediates retinal vascular dysfunction in diabetes mellitus publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.029004 – volume: 11 start-page: 3716 issue: 11 year: 2019 end-page: 3730 ident: CR29 article-title: Long non-coding RNA MEG3 promotes fibrosis and inflammatory response in diabetic nephropathy via miR-181a/ Egr-1/ TLR4 axis publication-title: Aging doi: 10.18632/aging.102011 – volume: 27 start-page: 33 issue: 1 year: 2019 end-page: 36 ident: CR32 article-title: Abnormal expression and clinical significance of miR-146a in peripheral blood mononuclear cells in microvascular complication of type 2 diabetes mellitus publication-title: Chin J Diabetes – volume: 25 start-page: 805 issue: 5 year: 2019 end-page: 813 ident: CR6 article-title: A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes publication-title: Nat Med doi: 10.1038/s41591-019-0415-5 – volume: 469 start-page: 319 issue: 2 year: 2016 end-page: 325 ident: CR33 article-title: Kang DM (2016) Upregulation of lncRNA MEG3 promotes hepatic insulin resistance via increasing FoxO1 expression publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2015.11.048 – year: 2019 ident: CR2 article-title: Type 2 Diabetes Mellitus and Heart Failure: a Scientific Statement From the American Heart Association and the Heart Failure Society of America publication-title: Circulation doi: 10.1016/j.cardfail.2019.05.007 – volume: 341 start-page: 789 issue: 6147 year: 2013 end-page: 792 ident: CR7 article-title: A long noncoding RNA mediates both activation and repression of immune response genes publication-title: Science doi: 10.1126/science.1240925 – volume: 123 start-page: 1298 issue: 12 year: 2018 end-page: 1312 ident: CR24 article-title: A novel angiotensin II-induced long noncoding RNA giver regulates oxidative stress, inflammation, and proliferation in vascular smooth muscle cells publication-title: Circ Res doi: 10.1161/CIRCRESAHA.118.313207 – volume: 25 start-page: 241 issue: 1 year: 2018 end-page: 255 ident: CR8 article-title: Extracellular vesicle-mimetic nanovesicles transport LncRNA-H19 as competing endogenous RNA for the treatment of diabetic wounds publication-title: Drug Deliv doi: 10.1080/10717544.2018.1425774 – year: 2018 ident: CR28 publication-title: Screening and functional study of differential expression profiles of lnc RNAs in type 2 diabetes mellitus – volume: 43 start-page: S14 issue: Supplement 1 year: 2020 end-page: S31 ident: CR20 article-title: Classification and diagnosis of diabetes: standards of medical care in diabetes-2020 publication-title: Diabetes Care doi: 10.2337/dc20-S002 – volume: 132 start-page: 1811 issue: 16 year: 2018 end-page: 1836 ident: CR22 article-title: A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes publication-title: Clin Sci doi: 10.1042/CS20171459 – volume: 19 start-page: 135 issue: 1 year: 2014 end-page: 145 ident: CR15 article-title: Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets publication-title: Cell Metab doi: 10.1016/j.cmet.2013.11.016 – volume: 54 start-page: 8179 year: 2017 end-page: 8190 ident: CR30 article-title: Downregulation of the long non-coding RNA Meg3 promotes angiogenesis after ischemic brain injury by activating notch signaling publication-title: Mol Neurobiol doi: 10.1007/s12035-016-0270-z – volume: 5 start-page: 211 issue: 3 year: 2000 end-page: 220 ident: CR10 article-title: Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q publication-title: Genes Cells doi: 10.1046/j.1365-2443.2000.00320.x – volume: 42 start-page: 68 issue: 1 year: 2010 end-page: 71 ident: CR26 article-title: The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes publication-title: Nat Genet doi: 10.1038/ng.493 – volume: 31 start-page: 2543 issue: 12 year: 2017 end-page: 2551 ident: CR11 article-title: Dysfunction of the WT1-MEG3 signaling promotes AML leukemogenesis via p53-dependent and independent pathways publication-title: Leukemia doi: 10.1038/leu.2017.116 – volume: 675 start-page: 265 year: 2018 end-page: 271 ident: CR16 article-title: Genetic variants in long noncoding RNA H19 and MEG3 confer risk of type 2 diabetes in an Iranian population publication-title: Gene doi: 10.1016/j.gene.2018.07.002 – volume: 19 start-page: 519 issue: 5 year: 2008 end-page: 524 ident: CR23 article-title: Inflammation and immunity in diabetic vascular complications publication-title: Curr Opin Lipidol doi: 10.1097/MOL.0b013e32830f47cd – volume: 418 start-page: 185 year: 2018 end-page: 195 ident: CR3 article-title: Long non-coding RNA XIST promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-367/141-ZEB2 axis in non-small-cell lung cancer publication-title: Cancer Lett doi: 10.1016/j.canlet.2018.01.036 – volume: 25 start-page: 402 year: 2001 end-page: 408 ident: CR19 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method publication-title: Methods doi: 10.1006/meth.2001.1262 – volume: 139 start-page: 1320 issue: 10 year: 2019 end-page: 1334 ident: CR13 article-title: Hematopoietic deficiency of the long noncoding RNA MALAT1 promotes atherosclerosis and plaque inflammation publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.029015 – volume: 129 start-page: 503 issue: 2 year: 2019 end-page: 505 ident: CR4 article-title: Colorectal cancer: the APC-lncRNA link publication-title: J Clin Invest doi: 10.1172/JCI125985 – volume: 231 start-page: 852 issue: 4 year: 2016 end-page: 862 ident: CR27 article-title: Downregulation of long noncoding RNA Meg3 affects insulin synthesis and secretion in mouse pancreatic beta cells publication-title: J Cell Physiol doi: 10.1002/jcp.25175 – year: 2020 ident: CR17 article-title: LncRNA MEG3 inhibits the inflammatory response of ankylosing spondylitis by targeting miR-146a publication-title: Mol Cell Biochem doi: 10.1007/s11010-019-03681-x – volume: 34 start-page: 812 issue: 5 year: 2018 end-page: 819 ident: CR31 article-title: Constructing prediction models from expression profiles for large scale lncRNA-miRNA interaction profiling publication-title: Bioinformatics doi: 10.1093/bioinformatics/btx672 – volume: 15 start-page: 83 issue: 2 year: 2018 end-page: 96 ident: CR5 article-title: Reverse remodelling and myocardial recovery in heart failure publication-title: Nat Rev Cardiol doi: 10.1038/nrcardio.2017.139 – volume: 138 start-page: 271 year: 2018 end-page: 281 ident: CR1 article-title: IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045 publication-title: Diabetes Res Clin Pract doi: 10.1016/j.diabres.2018.02.023 – volume: 15 start-page: 3251 issue: 21 year: 2018 end-page: 3253 ident: CR18 article-title: The relationship between miR-146a and inflammatory response, oxidative stress in diabetic kidney disease publication-title: Lab Med Clin – volume: 8 start-page: 207 issue: 8 year: 2017 ident: CR25 article-title: Long noncoding RNAs as diagnostic and therapeutic targets in type 2 diabetes and related complications publication-title: Genes doi: 10.3390/genes8080207 – volume: 30 start-page: 148 year: 2018 end-page: 157 ident: CR12 article-title: MEG3 activated by vitamin D inhibits colorectal cancer cells proliferation and migration via regulating clusterin publication-title: E Bio Med doi: 10.1016/j.ebiom.2018.03.032 – volume: 341 start-page: 789 issue: 6147 year: 2013 ident: 3810_CR7 publication-title: Science doi: 10.1126/science.1240925 – volume: 5 start-page: 211 issue: 3 year: 2000 ident: 3810_CR10 publication-title: Genes Cells doi: 10.1046/j.1365-2443.2000.00320.x – volume: 38 start-page: 69 issue: 10 year: 2019 ident: 3810_CR21 publication-title: Chin Health Econ – volume: 418 start-page: 185 year: 2018 ident: 3810_CR3 publication-title: Cancer Lett doi: 10.1016/j.canlet.2018.01.036 – volume: 54 start-page: 8179 year: 2017 ident: 3810_CR30 publication-title: Mol Neurobiol doi: 10.1007/s12035-016-0270-z – volume: 11 start-page: 3716 issue: 11 year: 2019 ident: 3810_CR29 publication-title: Aging doi: 10.18632/aging.102011 – volume: 60 start-page: 444 issue: 2 year: 2019 ident: 3810_CR14 publication-title: Int Heart J doi: 10.1536/ihj.18-195 – volume: 25 start-page: 805 issue: 5 year: 2019 ident: 3810_CR6 publication-title: Nat Med doi: 10.1038/s41591-019-0415-5 – volume: 27 start-page: 33 issue: 1 year: 2019 ident: 3810_CR32 publication-title: Chin J Diabetes – volume: 138 start-page: 271 year: 2018 ident: 3810_CR1 publication-title: Diabetes Res Clin Pract doi: 10.1016/j.diabres.2018.02.023 – volume: 42 start-page: 68 issue: 1 year: 2010 ident: 3810_CR26 publication-title: Nat Genet doi: 10.1038/ng.493 – volume: 25 start-page: 241 issue: 1 year: 2018 ident: 3810_CR8 publication-title: Drug Deliv doi: 10.1080/10717544.2018.1425774 – volume: 136 start-page: 1629 issue: 17 year: 2017 ident: 3810_CR9 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.029004 – volume: 43 start-page: S14 issue: Supplement 1 year: 2020 ident: 3810_CR20 publication-title: Diabetes Care doi: 10.2337/dc20-S002 – volume: 139 start-page: 1320 issue: 10 year: 2019 ident: 3810_CR13 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.029015 – volume: 231 start-page: 852 year: 2016 ident: 3810_CR35 publication-title: J Cell Physiol doi: 10.1002/jcp.25175 – volume: 34 start-page: 812 issue: 5 year: 2018 ident: 3810_CR31 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btx672 – volume: 25 start-page: 402 year: 2001 ident: 3810_CR19 publication-title: Methods doi: 10.1006/meth.2001.1262 – volume-title: Differential expression of lncRNA MEG3 in patients with different glycometabolism and analysis of related functions year: 2018 ident: 3810_CR34 – volume: 15 start-page: 3251 issue: 21 year: 2018 ident: 3810_CR18 publication-title: Lab Med Clin – volume: 123 start-page: 1298 issue: 12 year: 2018 ident: 3810_CR24 publication-title: Circ Res doi: 10.1161/CIRCRESAHA.118.313207 – volume: 15 start-page: 83 issue: 2 year: 2018 ident: 3810_CR5 publication-title: Nat Rev Cardiol doi: 10.1038/nrcardio.2017.139 – volume: 19 start-page: 519 issue: 5 year: 2008 ident: 3810_CR23 publication-title: Curr Opin Lipidol doi: 10.1097/MOL.0b013e32830f47cd – volume: 132 start-page: 1811 issue: 16 year: 2018 ident: 3810_CR22 publication-title: Clin Sci doi: 10.1042/CS20171459 – volume: 8 start-page: 207 issue: 8 year: 2017 ident: 3810_CR25 publication-title: Genes doi: 10.3390/genes8080207 – year: 2020 ident: 3810_CR17 publication-title: Mol Cell Biochem doi: 10.1007/s11010-019-03681-x – volume: 31 start-page: 2543 issue: 12 year: 2017 ident: 3810_CR11 publication-title: Leukemia doi: 10.1038/leu.2017.116 – volume: 129 start-page: 503 issue: 2 year: 2019 ident: 3810_CR4 publication-title: J Clin Invest doi: 10.1172/JCI125985 – year: 2019 ident: 3810_CR2 publication-title: Circulation doi: 10.1016/j.cardfail.2019.05.007 – volume: 675 start-page: 265 year: 2018 ident: 3810_CR16 publication-title: Gene doi: 10.1016/j.gene.2018.07.002 – volume: 231 start-page: 852 issue: 4 year: 2016 ident: 3810_CR27 publication-title: J Cell Physiol doi: 10.1002/jcp.25175 – volume: 30 start-page: 148 year: 2018 ident: 3810_CR12 publication-title: E Bio Med doi: 10.1016/j.ebiom.2018.03.032 – volume: 469 start-page: 319 issue: 2 year: 2016 ident: 3810_CR33 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2015.11.048 – volume-title: Screening and functional study of differential expression profiles of lnc RNAs in type 2 diabetes mellitus year: 2018 ident: 3810_CR28 – volume: 19 start-page: 135 issue: 1 year: 2014 ident: 3810_CR15 publication-title: Cell Metab doi: 10.1016/j.cmet.2013.11.016
SSID	ssj0010011
Score	2.385762
Snippet	Previous studies have indicated that long non-coding RNAs (lncRNAs) were closely related to diabetes. In this study, we aimed to explore the possible role and...
SourceID	proquest gale pubmed crossref springer
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	93
SubjectTerms	Aged Analysis Biochemistry Biomedical and Life Sciences Blood circulation disorders Blood Glucose - metabolism Cardiology Case studies Case-Control Studies Development and progression Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes therapy Diabetic Angiopathies - blood Disease control Ethylenediaminetetraacetic acid Female Glycosylated hemoglobin Hemoglobin Humans Leukocytes (mononuclear) Life Sciences Male Medical Biochemistry Medical research Medicine, Experimental MicroRNAs - blood Middle Aged Non-coding RNA Oncology Pathogenesis Peripheral blood mononuclear cells Polymerase chain reaction Reverse Transcriptase Polymerase Chain Reaction RNA RNA, Long Noncoding - biosynthesis Type 2 diabetes Up-Regulation Vascular diseases
SummonAdditionalLinks	– databaseName: SpringerLINK Contemporary 1997-Present dbid: RSV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9VAEB6kVeyLl3pptMoIgg8ayGaTk41vh9Lqgx6k2tK3JdmLFGpSzkX0qf0P_QP-Fn-Kv8SZ3I6nqKBPIezsspfZnZn9ZmcAnhak1-eCjBwyFchAMYUPS5X60AtLP7nxvon2efgmm0zU0VH-rnsUNuu93XtIsjmpl4_dRAPckrnD6FYUkua4TuJO8Xbcf384YAes5bTYQRQqkWXdU5nft7Eiji4fyr9IpUswaSN99m7-X79vwY1O28Rxyx634YqrNuFam3_y6yZc3-nTvd2Bs4PTaZuXnlYKa48ndfURq7oKTc3yDfcnY3y7-0ricfX9G9_cYoz9zS1-4rie88UMBxd1Z5HveLF3dcUOCnqJBRr6_ji_6NzksQlxexcO9nY_7LwOu-wMoUmSeB6W0qWkHkTSkvArGVgmXSK1nL44Hbk49sJZG0e5Ny53gmMeS5k6Fdk487b0I3kP1mgQbgswUTJyZIpHvlCk3rnclImNnbc2yp3LsgBEv0jadKHLOYPGiV4GXeZJ1jTJuplk_SWA50Od0zZwx1-pn_Haa97V1LIpuscJ1D-Oj6XHIwZgGZQNYHuFklbJrBb33KO702CmSYUSbFmnIoAnQzHXZA-3ytULphGKDJ0sHwVwv-W6od-SbNREShXAi57Flo3_eVAP_o38IWzEzKWNp-I2rM2nC_cIrprP8-PZ9HGzx34CnSYfcA priority: 102 providerName: Springer Nature
Title	Upregulation of long non-coding RNA MEG3 in type 2 diabetes mellitus complicated with vascular disease: a case–control study
URI	https://link.springer.com/article/10.1007/s11010-020-03810-x https://www.ncbi.nlm.nih.gov/pubmed/32594338 https://www.proquest.com/docview/2441102251 https://www.proquest.com/docview/2418729796
Volume	473
WOSCitedRecordID	wos000544226500002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAVX databaseName: Springer Nature Consortium list (Orbis Cascade Alliance) customDbUrl: eissn: 1573-4919 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0010011 issn: 0300-8177 databaseCode: RSV dateStart: 19970101 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7RFlQuPMorUFZGQuIAEXGcbBIuaKm2cKCr1UKrvUWJH6hSmyz7QOWC-A_8Q34JM46TZSvRC5dEUWzL1ow9j288A_C8QL0-42jkoKmABoosjF-msfENV_iRSWNsts-Tj8lolE6n2dg53BYurLI9E-1BrWpJPvLXKIY4WScxfzv76lPVKEJXXQmNLdihLAnChu6NOxSB9J0GRQj8lCeJuzTTXJ3jFgZG44mwssC_2BBMl4_nv-TTJcDUyqHD2_-7gjtwy2mgbNCwzF24pqs9uNHUpPy-B7sHbQm4e_DjeDZvatUj9Vht2FldfWFVXfmyJpnHJqMBOxq-F-y0YuTMZSFrnbnsnFJ9LlcL1kWta8XI7cva6Ffm0KE3rGAS379__nKR88xmvb0Px4fDzwcffFewwZdRFC79UugYNYZAKJSHJWHNqF7Eiioax30dhoZrpcIgM1JnmlMaZCFinQYqTIwqTV88gG1cg34ELEpFoNE6D0yRosanM1lGKtRGqSDTOkk84C21cumymVNRjbN8nYeZKJwjhXNL4fzCg5ddn1mTy-PK1i-ICXLa6DiyLNx9BZwfpczKB33CZAmn9WB_oyUSSW7-bvkhdwfEIl8zgwfPut_Uk4LeKl2vqA1P0fZJsr4HDxv26-Yt0GyNhEg9eNXy43rwfy_q8dVzeQI3Q9oSNlhxH7aX85V-Ctflt-XpYt6DrWSa2Gfag513w9F4gl9H4bhntx0-J59O_gBG6Czk
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAioXHuUVKGAkEAeIiO3NJkFCaFVaWnW7qlBb9WYSP6pKJVn2Ae0F8R_4H_wofgkzeS1bid564BRFcSw7-Tzj8TcPgGcp7usTjkYOmgpooOjU-VkcOt9xgzeJdq7M9rnfjwaD-OAg2VmAX00sDLlVNjKxFNSm0HRG_hrVECfrJOTvhl98qhpF7GpTQqOCxZY9_YYm2_jt5nv8v8-FWF_bXd3w66oCvu50xMTPpA1RrQXSoNDOiBBFHRgaKrsbdq0QjltjRJA4bRPLKVevlKGNAyMiZzLXldjvJbiMwxFx6Sq407IWtL-qWIvAj3kU1UE6VageL2lnNNaImwv8kzlFeFYd_KUPzxC0pd5bv_G_fbGbcL3eYbNetSRuwYLNl-FqVXPzdBmWVpsSd7fh-95wZA_rAmascOy4yA9ZXuS-Lkins4-DHtte-yDZUc7osJoJ1hxWs8-UynQyHbPWK98aRsfarPHuZTX79YalTOP194-fdWQAK7P63oG9C_kQd2ER52DvA-vEMrAxCk-XxrijtYnOOkZYZ0yQWBtFHvAGHUrX2dqpaMixmuWZJkQpRJQqEaVOPHjZvjOscpWc2_oFgU6RIMOedVrHY-D4KCWY6nWJcyYe2oOVuZb4k_T84wZ_qhaAYzUDnwdP28f0Jjn15baYUhseo20XJV0P7lVwb8ct0SzvSBl78KrB_6zzf0_qwfljeQJLG7vbfdXfHGw9hGuClmPpmLkCi5PR1D6CK_rr5Gg8elwubAafLnpd_AFsSIGc
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3JbtRAEC2FsF5YwmYI0EggDmDF3R6PbSSERkkGooTRCBGUW2P3EkUK9jALJBfEP_A3fA5fQpXd9jCRyC0HTqOR2622XUtXv6pXAE8y3NenHIMcDBUwQFGZ9fMksr7lGv-kytqK7fPjTjwYJHt76XAJfjW1MJRW2djEylDrUtEZ-Rq6IU7RScTXrEuLGG70X4---NRBipDWpp1GLSLb5vgbhm-TV1sb-K2fCtHf_LD-1ncdBnzV6Yipn4cmQhcXhBoNeE7gKPrDSFML3qhrhLDcaC2C1CqTGk68vWEYmSTQIrY6t90Q5z0H52MiLa_SBoctgkF7rRrBCPyEx7Er2KnL9ngFQWPgRjhd4B8tOMWTruEv33gCrK18YP_a__z2rsNVt_NmvVpVbsCSKVbgYt2L83gFLq83re9uwvfd0djsu8ZmrLTssCz2WVEWvirJ17P3gx57t_kmZAcFo0NsJlhziM0-E8XpdDZhbba-0YyOu1mT9cscKvaSZUzh7-8fP13FAKvYfm_B7pm8iNuwjM9g7gLrJGFgEjSqNktwp2tSlXe0MFbrIDUmjj3gjaRI5VjcqZnIoZzzT5N0SZQuWUmXPPLgeXvPqOYwOXX0MxJASQYOZ1aZq9PA9RFVmOx1CYsmfNqD1YWR-JHU4uVGFqUzjBM5F0QPHreX6U5K9itMOaMxPMGYL067HtypRb9dd4jheicMEw9eNLown_zfD3Xv9LU8gkuoDnJna7B9H64I0swqX3MVlqfjmXkAF9TX6cFk_LDScQafzlot_gD2TYpZ
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Upregulation+of+long+non-coding+RNA+MEG3+in+type+2+diabetes+mellitus+complicated+with+vascular+disease%3A+a+case%E2%80%93control+study&rft.jtitle=Molecular+and+cellular+biochemistry&rft.au=Wei-wei%2C+Chang&rft.au=Zhang%2C+Liu&rft.au=Xin-ming%2C+Yao&rft.au=Chen%2C+Yan&rft.date=2020-10-01&rft.pub=Springer+Nature+B.V&rft.issn=0300-8177&rft.eissn=1573-4919&rft.volume=473&rft.issue=1-2&rft.spage=93&rft.epage=99&rft_id=info:doi/10.1007%2Fs11010-020-03810-x&rft.externalDBID=HAS_PDF_LINK
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0300-8177&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0300-8177&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0300-8177&client=summon