Bifenthrin exerts proatherogenic effects via arterial accumulation of native and oxidized LDL in rats: the beneficial role of vitamin E and selenium

The purpose of this study was to investigate, for the first time, the effects of Bifenthrin (Bif) chronic exposure on plasmatic and aortic lipid parameters disturbance and their pro-atherogenic possibility in Wistar rats. The ameliorative role of vitamin E (Vit E) and selenium (Se) were also targete...

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Published in:Environmental science and pollution research international Vol. 27; no. 6; pp. 5651 - 5660
Main Authors: Feriani, Anouar, Hachani, Rafik, Tir, Meriam, Ghazouani, Lakhdar, Mufti, Afoua, Borgi, Mohamed Ali, Allagui, Mohamed Salah
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2020
Springer Nature B.V
Subjects:
Animals
antioxidant activity
Antioxidants
Aorta
Aorta - drug effects
Aorta - pathology
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
bifenthrin
CD36 antigen
Cholesterol
Cholesterol, LDL
Chronic exposure
Cytokines
Densitometers
densitometry
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental Pollution
Environmental science
Food Contamination
histology
Inflammation
Insecticides
Interleukin 2
Interleukin 6
laboratory animals
Lipids
Lipoproteins, LDL
Low density lipoprotein
low density lipoprotein cholesterol
low density lipoprotein receptors
Male
oxidation
Proteins
Pyrethrins - toxicity
Rats
Rats, Wistar
Receptors
Risk Assessment and Remediation
Rodents
Scavenger receptors
Selenium
Selenium - pharmacology
staining
Tocopherol
Toxicity
tumor necrosis factor-alpha
Tumor necrosis factor-α
Vitamin E
Vitamin E - pharmacology
Waste Water Technology
Water Management
Water Pollution Control
Pro-atherogenic
Vit E-Se
Aorta
LDL
Bifenthrin
Lipid
ISSN:0944-1344, 1614-7499, 1614-7499
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Summary:The purpose of this study was to investigate, for the first time, the effects of Bifenthrin (Bif) chronic exposure on plasmatic and aortic lipid parameters disturbance and their pro-atherogenic possibility in Wistar rats. The ameliorative role of vitamin E (Vit E) and selenium (Se) were also targeted. Thus, rats were treated by gastric gavage with combination of Vit E (100 mg/kg/bw) and Se (0.25 mg/kg/bw) in alone and co-treated groups for 90 days. Apart from control and Vit E-Se groups, all the groups were subjected to Bif (3 mg/kg, via gavage) toxicity. Results showed that Bif increased markedly plasmatic and aortic total cholesterol, LDL-cholesterol, native LDL-apoB-100, and oxidized-LDL, compared to the control. Moreover, Bif treatment significantly increased the plasmatic levels of the pro-inflammatory cytokines TNF-α, IL-2, and IL-6. In addition, the densitometric quantification of protein bands showed that the amount of hepatic native LDL-receptor protein decreased significantly in the intoxicated rats compared to the control group. The expression of arterial LDL receptors (LDLRs) and scavenger receptors (CD36) was amplified owing to Bif toxicity. This harmful effect was confirmed by histological study using Oil-Red-O staining. Owing to their antioxidant capacities, Vit E and Se have maintained all the changes in plasma and aorta lipids and prevented the pro-atherogenic effect observed in Bif-treated animals.
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ISSN:0944-1344
1614-7499
1614-7499
DOI:10.1007/s11356-018-3771-7