Pre-existing humoral immunity and complement pathway contribute to immunogenicity of adeno-associated virus (AAV) vector in human blood

AAV gene transfer is a promising treatment for many patients with life-threatening genetic diseases. However, host immune response to the vector poses a significant challenge for the durability and safety of AAV-mediated gene therapy. Here, we characterize the innate immune response to AAV in human...

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Vydáno v:	Frontiers in immunology Ročník 13; s. 999021
Hlavní autoři:	Smith, Corinne J., Ross, Nikki, Kamal, Ali, Kim, Kevin Y., Kropf, Elizabeth, Deschatelets, Pascal, Francois, Cedric, Quinn, William J., Singh, Inderpal, Majowicz, Anna, Mingozzi, Federico, Kuranda, Klaudia
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Frontiers Media S.A 16.09.2022
Témata:	AAV complement gene therapy Immunology innate immunity neutralizing antibodies
ISSN:	1664-3224, 1664-3224
On-line přístup:	Získat plný text
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