TLR2 activation promotes tumour growth and associates with patient survival and chemotherapy response in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis, and is plagued by a paucity of targeted treatment options and tumour resistance to chemotherapeutics. The causal link between chronic inflammation and PDAC suggests that molecular regulators of the immune system promote disease...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Oncogene Ročník 40; číslo 41; s. 6007 - 6022
Hlavní autori:	Lundy, Joanne, Gearing, Linden J., Gao, Hugh, West, Alison C., McLeod, Louise, Deswaerte, Virginie, Yu, Liang, Porazinski, Sean, Pajic, Marina, Hertzog, Paul J., Croagh, Daniel, Jenkins, Brendan J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 14.10.2021 Nature Publishing Group
Predmet:	38/1 38/23 38/39 38/77 38/91 45 631/250/262 631/67/1059/2326 631/67/1059/602 631/67/1504/1713 64/60 82/51 Adenocarcinoma Animals Apoptosis Biopsy Cancer Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Care and treatment Cell Biology Cell Growth Processes - drug effects Cell Growth Processes - physiology Cell Line, Tumor Cellular signal transduction Chemoresistance Chemotherapy Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Female Gemcitabine Genetic aspects Health aspects Human Genetics Humans Immune system Internal Medicine Medical prognosis Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Inbred NOD Molecular Targeted Therapy Oncology Pancreas Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreatic tumors Patient outcomes Patients Precision medicine Prognosis Survival Survival Analysis Therapeutic targets TLR2 TLR2 protein Toll-Like Receptor 2 - antagonists & inhibitors Toll-Like Receptor 2 - metabolism Toll-like receptors Transcriptomes Tumors Xenograft Model Antitumor Assays Xenografts Australia
ISSN:	0950-9232, 1476-5594, 1476-5594
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!