TLR2 activation promotes tumour growth and associates with patient survival and chemotherapy response in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis, and is plagued by a paucity of targeted treatment options and tumour resistance to chemotherapeutics. The causal link between chronic inflammation and PDAC suggests that molecular regulators of the immune system promote disease...

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Bibliographic Details
Published in:	Oncogene Vol. 40; no. 41; pp. 6007 - 6022
Main Authors:	Lundy, Joanne, Gearing, Linden J., Gao, Hugh, West, Alison C., McLeod, Louise, Deswaerte, Virginie, Yu, Liang, Porazinski, Sean, Pajic, Marina, Hertzog, Paul J., Croagh, Daniel, Jenkins, Brendan J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.10.2021 Nature Publishing Group
Subjects:	38/1 38/23 38/39 38/77 38/91 45 631/250/262 631/67/1059/2326 631/67/1059/602 631/67/1504/1713 64/60 82/51 Adenocarcinoma Animals Apoptosis Biopsy Cancer Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Care and treatment Cell Biology Cell Growth Processes - drug effects Cell Growth Processes - physiology Cell Line, Tumor Cellular signal transduction Chemoresistance Chemotherapy Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Female Gemcitabine Genetic aspects Health aspects Human Genetics Humans Immune system Internal Medicine Medical prognosis Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Inbred NOD Molecular Targeted Therapy Oncology Pancreas Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreatic tumors Patient outcomes Patients Precision medicine Prognosis Survival Survival Analysis Therapeutic targets TLR2 TLR2 protein Toll-Like Receptor 2 - antagonists & inhibitors Toll-Like Receptor 2 - metabolism Toll-like receptors Transcriptomes Tumors Xenograft Model Antitumor Assays Xenografts Australia
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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