Dendrobium officinale polysaccharide ameliorates polycystic ovary syndrome via regulating butyrate dependent gut–brain–ovary axis mechanism
Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats. However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut micr...
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| Vydáno v: | Frontiers in endocrinology (Lausanne) Ročník 13; s. 962775 |
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| Jazyk: | angličtina |
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Frontiers Media S.A
05.08.2022
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| ISSN: | 1664-2392, 1664-2392 |
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| Abstract | Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats. However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut microbiota in the large intestine and regulates the composition of gut microbiota. How DOP improved ovarian function in PCOS rats through the blood–brain barrier is unclear. In this study, we generated letrozole-induced PCOS rat models and studied the therapeutic effect and mechanism of DOP. 16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed. We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats. In addition, compared with PCOS rats, those treated with DOP exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression. These results indicated that DOP relieved the symptoms of PCOS rats which may be related to the mechanism of butyrate dependent gut–brain–ovary axis protection. |
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| AbstractList | Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats. However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut microbiota in the large intestine and regulates the composition of gut microbiota. How DOP improved ovarian function in PCOS rats through the blood–brain barrier is unclear. In this study, we generated letrozole-induced PCOS rat models and studied the therapeutic effect and mechanism of DOP. 16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed. We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats. In addition, compared with PCOS rats, those treated with DOP exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression. These results indicated that DOP relieved the symptoms of PCOS rats which may be related to the mechanism of butyrate dependent gut–brain–ovary axis protection. Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats. However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut microbiota in the large intestine and regulates the composition of gut microbiota. How DOP improved ovarian function in PCOS rats through the blood-brain barrier is unclear. In this study, we generated letrozole-induced PCOS rat models and studied the therapeutic effect and mechanism of DOP. 16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed. We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats. In addition, compared with PCOS rats, those treated with DOP exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression. These results indicated that DOP relieved the symptoms of PCOS rats which may be related to the mechanism of butyrate dependent gut-brain-ovary axis protection.Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats. However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut microbiota in the large intestine and regulates the composition of gut microbiota. How DOP improved ovarian function in PCOS rats through the blood-brain barrier is unclear. In this study, we generated letrozole-induced PCOS rat models and studied the therapeutic effect and mechanism of DOP. 16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed. We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats. In addition, compared with PCOS rats, those treated with DOP exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression. These results indicated that DOP relieved the symptoms of PCOS rats which may be related to the mechanism of butyrate dependent gut-brain-ovary axis protection. |
| Author | Hu, Linlin ling, Bo Lu, Haishan Jiang, Qinyang Huang, Yanna Wang, Decai Feng, Xueping |
| AuthorAffiliation | 1 College of Animal Science & Technology, Guangxi University , Nanning , China 2 College of Basic Medicine, Youjiang Medical University for Nationalities , Baise , China 5 Department of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities , Baise , China 3 Department of Library, Youjiang Medical University for Nationalities , Baise , China 4 Reproductive Medicine Center, The Affiliated Hospital of Youjiang Medical University for Nationalities , Baise , China 6 College of Pharmacy, Youjiang Medical University for Nationalities , Baise , China |
| AuthorAffiliation_xml | – name: 1 College of Animal Science & Technology, Guangxi University , Nanning , China – name: 2 College of Basic Medicine, Youjiang Medical University for Nationalities , Baise , China – name: 6 College of Pharmacy, Youjiang Medical University for Nationalities , Baise , China – name: 3 Department of Library, Youjiang Medical University for Nationalities , Baise , China – name: 4 Reproductive Medicine Center, The Affiliated Hospital of Youjiang Medical University for Nationalities , Baise , China – name: 5 Department of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities , Baise , China |
| Author_xml | – sequence: 1 givenname: Xueping surname: Feng fullname: Feng, Xueping – sequence: 2 givenname: Decai surname: Wang fullname: Wang, Decai – sequence: 3 givenname: Linlin surname: Hu fullname: Hu, Linlin – sequence: 4 givenname: Haishan surname: Lu fullname: Lu, Haishan – sequence: 5 givenname: Bo surname: ling fullname: ling, Bo – sequence: 6 givenname: Yanna surname: Huang fullname: Huang, Yanna – sequence: 7 givenname: Qinyang surname: Jiang fullname: Jiang, Qinyang |
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| Copyright | Copyright © 2022 Feng, Wang, Hu, Lu, ling, Huang and Jiang. Copyright © 2022 Feng, Wang, Hu, Lu, ling, Huang and Jiang 2022 Feng, Wang, Hu, Lu, ling, Huang and Jiang |
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| SubjectTerms | butyrate dendrobium officinale polysaccharide Endocrinology gut microbiota ovary polycystic ovary syndrome |
| Title | Dendrobium officinale polysaccharide ameliorates polycystic ovary syndrome via regulating butyrate dependent gut–brain–ovary axis mechanism |
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