Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant

Synthetic devices for traceless remote control of gene expression may provide new treatment opportunities in future gene- and cell-based therapies. Here we report the design of a synthetic mind-controlled gene switch that enables human brain activities and mental states to wirelessly programme the t...

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Bibliographic Details
Published in:	Nature communications Vol. 5; no. 1; p. 5392
Main Authors:	Folcher, Marc, Oesterle, Sabine, Zwicky, Katharina, Thekkottil, Thushara, Heymoz, Julie, Hohmann, Muriel, Christen, Matthias, Daoud El-Baba, Marie, Buchmann, Peter, Fussenegger, Martin
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11.11.2014 Nature Publishing Group Nature Pub. Group
Subjects:	631/1647/2253 631/378 631/61/338/552 631/61/54/993 Alkaline Phosphatase - biosynthesis Animals Brain-Computer Interfaces Cybernetics Cyclic GMP - analogs & derivatives Cyclic GMP - metabolism Design Electroencephalography Female Gene Expression Humanities and Social Sciences Humans Implants, Experimental Interferon Kinases Light Metabolism Mice multidisciplinary Optogenetics - methods Prostheses Remote control Science Science (multidisciplinary) Signal Transduction Synthetic biology Transcription, Genetic Transgenes Transplants & implants Wireless Technology Basel Switzerland Switzerland
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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