Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant

Synthetic devices for traceless remote control of gene expression may provide new treatment opportunities in future gene- and cell-based therapies. Here we report the design of a synthetic mind-controlled gene switch that enables human brain activities and mental states to wirelessly programme the t...

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Veröffentlicht in:Nature communications Jg. 5; H. 1; S. 5392
Hauptverfasser: Folcher, Marc, Oesterle, Sabine, Zwicky, Katharina, Thekkottil, Thushara, Heymoz, Julie, Hohmann, Muriel, Christen, Matthias, Daoud El-Baba, Marie, Buchmann, Peter, Fussenegger, Martin
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 11.11.2014
Nature Publishing Group
Nature Pub. Group
Schlagworte:
631/1647/2253
631/378
631/61/338/552
631/61/54/993
Alkaline Phosphatase - biosynthesis
Animals
Brain-Computer Interfaces
Cybernetics
Cyclic GMP - analogs & derivatives
Cyclic GMP - metabolism
Design
Electroencephalography
Female
Gene Expression
Humanities and Social Sciences
Humans
Implants, Experimental
Interferon
Kinases
Light
Metabolism
Mice
multidisciplinary
Optogenetics - methods
Prostheses
Remote control
Science
Science (multidisciplinary)
Signal Transduction
Synthetic biology
Transcription, Genetic
Transgenes
Transplants & implants
Wireless Technology
Basel Switzerland
Switzerland
ISSN:2041-1723, 2041-1723
Online-Zugang:Volltext
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Abstract Synthetic devices for traceless remote control of gene expression may provide new treatment opportunities in future gene- and cell-based therapies. Here we report the design of a synthetic mind-controlled gene switch that enables human brain activities and mental states to wirelessly programme the transgene expression in human cells. An electroencephalography (EEG)-based brain–computer interface (BCI) processing mental state-specific brain waves programs an inductively linked wireless-powered optogenetic implant containing designer cells engineered for near-infrared (NIR) light-adjustable expression of the human glycoprotein SEAP (secreted alkaline phosphatase). The synthetic optogenetic signalling pathway interfacing the BCI with target gene expression consists of an engineered NIR light-activated bacterial diguanylate cyclase (DGCL) producing the orthogonal second messenger cyclic diguanosine monophosphate (c-di-GMP), which triggers the stimulator of interferon genes (STING)-dependent induction of synthetic interferon-β promoters. Humans generating different mental states (biofeedback control, concentration, meditation) can differentially control SEAP production of the designer cells in culture and of subcutaneous wireless-powered optogenetic implants in mice. Brain–machine interfaces offer the possibility of controlling prosthetic devices using changes in brain activity. Folcher et al. couple such a system wirelessly to an optogenetic implant in mice to control expression of a transgene, demonstrating its potential for mind-controlled drug delivery.
AbstractList Synthetic devices for traceless remote control of gene expression may provide new treatment opportunities in future gene- and cell-based therapies. Here we report the design of a synthetic mind-controlled gene switch that enables human brain activities and mental states to wirelessly programme the transgene expression in human cells. An electroencephalography (EEG)-based brain-computer interface (BCI) processing mental state-specific brain waves programs an inductively linked wireless-powered optogenetic implant containing designer cells engineered for near-infrared (NIR) light-adjustable expression of the human glycoprotein SEAP (secreted alkaline phosphatase). The synthetic optogenetic signalling pathway interfacing the BCI with target gene expression consists of an engineered NIR light-activated bacterial diguanylate cyclase (DGCL) producing the orthogonal second messenger cyclic diguanosine monophosphate (c-di-GMP), which triggers the stimulator of interferon genes (STING)-dependent induction of synthetic interferon-β promoters. Humans generating different mental states (biofeedback control, concentration, meditation) can differentially control SEAP production of the designer cells in culture and of subcutaneous wireless-powered optogenetic implants in mice.
Synthetic devices for traceless remote control of gene expression may provide new treatment opportunities in future gene- and cell-based therapies. Here we report the design of a synthetic mind-controlled gene switch that enables human brain activities and mental states to wirelessly programme the transgene expression in human cells. An electroencephalography (EEG)-based brain–computer interface (BCI) processing mental state-specific brain waves programs an inductively linked wireless-powered optogenetic implant containing designer cells engineered for near-infrared (NIR) light-adjustable expression of the human glycoprotein SEAP (secreted alkaline phosphatase). The synthetic optogenetic signalling pathway interfacing the BCI with target gene expression consists of an engineered NIR light-activated bacterial diguanylate cyclase (DGCL) producing the orthogonal second messenger cyclic diguanosine monophosphate (c-di-GMP), which triggers the stimulator of interferon genes (STING)-dependent induction of synthetic interferon-β promoters. Humans generating different mental states (biofeedback control, concentration, meditation) can differentially control SEAP production of the designer cells in culture and of subcutaneous wireless-powered optogenetic implants in mice. Brain–machine interfaces offer the possibility of controlling prosthetic devices using changes in brain activity. Folcher et al. couple such a system wirelessly to an optogenetic implant in mice to control expression of a transgene, demonstrating its potential for mind-controlled drug delivery.
Synthetic devices for traceless remote control of gene expression may provide new treatment opportunities in future gene- and cell-based therapies. Here we report the design of a synthetic mind-controlled gene switch that enables human brain activities and mental states to wirelessly programme the transgene expression in human cells. An electroencephalography (EEG)-based brain-computer interface (BCI) processing mental state-specific brain waves programs an inductively linked wireless-powered optogenetic implant containing designer cells engineered for near-infrared (NIR) light-adjustable expression of the human glycoprotein SEAP (secreted alkaline phosphatase). The synthetic optogenetic signalling pathway interfacing the BCI with target gene expression consists of an engineered NIR light-activated bacterial diguanylate cyclase (DGCL) producing the orthogonal second messenger cyclic diguanosine monophosphate (c-di-GMP), which triggers the stimulator of interferon genes (STING)-dependent induction of synthetic interferon-β promoters. Humans generating different mental states (biofeedback control, concentration, meditation) can differentially control SEAP production of the designer cells in culture and of subcutaneous wireless-powered optogenetic implants in mice.Synthetic devices for traceless remote control of gene expression may provide new treatment opportunities in future gene- and cell-based therapies. Here we report the design of a synthetic mind-controlled gene switch that enables human brain activities and mental states to wirelessly programme the transgene expression in human cells. An electroencephalography (EEG)-based brain-computer interface (BCI) processing mental state-specific brain waves programs an inductively linked wireless-powered optogenetic implant containing designer cells engineered for near-infrared (NIR) light-adjustable expression of the human glycoprotein SEAP (secreted alkaline phosphatase). The synthetic optogenetic signalling pathway interfacing the BCI with target gene expression consists of an engineered NIR light-activated bacterial diguanylate cyclase (DGCL) producing the orthogonal second messenger cyclic diguanosine monophosphate (c-di-GMP), which triggers the stimulator of interferon genes (STING)-dependent induction of synthetic interferon-β promoters. Humans generating different mental states (biofeedback control, concentration, meditation) can differentially control SEAP production of the designer cells in culture and of subcutaneous wireless-powered optogenetic implants in mice.
Synthetic devices for traceless remote control of gene expression may provide new treatment opportunities in future gene- and cell-based therapies. Here we report the design of a synthetic mind-controlled gene switch that enables human brain activities and mental states to wirelessly programme the transgene expression in human cells. An electroencephalography (EEG)-based brain–computer interface (BCI) processing mental state-specific brain waves programs an inductively linked wireless-powered optogenetic implant containing designer cells engineered for near-infrared (NIR) light-adjustable expression of the human glycoprotein SEAP (secreted alkaline phosphatase). The synthetic optogenetic signalling pathway interfacing the BCI with target gene expression consists of an engineered NIR light-activated bacterial diguanylate cyclase (DGCL) producing the orthogonal second messenger cyclic diguanosine monophosphate (c-di-GMP), which triggers the stimulator of interferon genes (STING)-dependent induction of synthetic interferon-β promoters. Humans generating different mental states (biofeedback control, concentration, meditation) can differentially control SEAP production of the designer cells in culture and of subcutaneous wireless-powered optogenetic implants in mice. Brain–machine interfaces offer the possibility of controlling prosthetic devices using changes in brain activity. Folcher et al. couple such a system wirelessly to an optogenetic implant in mice to control expression of a transgene, demonstrating its potential for mind-controlled drug delivery.
ArticleNumber 5392
Author Daoud El-Baba, Marie
Christen, Matthias
Thekkottil, Thushara
Buchmann, Peter
Folcher, Marc
Oesterle, Sabine
Heymoz, Julie
Hohmann, Muriel
Fussenegger, Martin
Zwicky, Katharina
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  surname: Folcher
  fullname: Folcher, Marc
  organization: Department of Biosystems Science and Engineering, ETH Zurich
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  givenname: Sabine
  surname: Oesterle
  fullname: Oesterle, Sabine
  organization: Department of Biosystems Science and Engineering, ETH Zurich
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  givenname: Katharina
  surname: Zwicky
  fullname: Zwicky, Katharina
  organization: Department of Biosystems Science and Engineering, ETH Zurich
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  givenname: Thushara
  surname: Thekkottil
  fullname: Thekkottil, Thushara
  organization: Department of Biosystems Science and Engineering, ETH Zurich
– sequence: 5
  givenname: Julie
  surname: Heymoz
  fullname: Heymoz, Julie
  organization: Department of Biosystems Science and Engineering, ETH Zurich
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  surname: Hohmann
  fullname: Hohmann, Muriel
  organization: Department of Biosystems Science and Engineering, ETH Zurich
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  surname: Christen
  fullname: Christen, Matthias
  organization: Department of Biosystems Science and Engineering, ETH Zurich
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  givenname: Marie
  surname: Daoud El-Baba
  fullname: Daoud El-Baba, Marie
  organization: Département Génie Biologique, Institut Universitaire de Technologie (IUTA)
– sequence: 9
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  surname: Buchmann
  fullname: Buchmann, Peter
  organization: Department of Biosystems Science and Engineering, ETH Zurich
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  givenname: Martin
  surname: Fussenegger
  fullname: Fussenegger, Martin
  email: fussenegger@bsse.ethz.ch
  organization: Department of Biosystems Science and Engineering, ETH Zurich, Faculty of Science, University of Basel
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25386727$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright The Author(s) 2014
Copyright Nature Publishing Group Nov 2014
Copyright © 2014, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Copyright_xml – notice: The Author(s) 2014
– notice: Copyright Nature Publishing Group Nov 2014
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Snippet Synthetic devices for traceless remote control of gene expression may provide new treatment opportunities in future gene- and cell-based therapies. Here we...
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springer
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StartPage 5392
SubjectTerms 631/1647/2253
631/378
631/61/338/552
631/61/54/993
Alkaline Phosphatase - biosynthesis
Animals
Brain-Computer Interfaces
Cybernetics
Cyclic GMP - analogs & derivatives
Cyclic GMP - metabolism
Design
Electroencephalography
Female
Gene Expression
Humanities and Social Sciences
Humans
Implants, Experimental
Interferon
Kinases
Light
Metabolism
Mice
multidisciplinary
Optogenetics - methods
Prostheses
Remote control
Science
Science (multidisciplinary)
Signal Transduction
Synthetic biology
Transcription, Genetic
Transgenes
Transplants & implants
Wireless Technology
Title Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant
URI https://link.springer.com/article/10.1038/ncomms6392
https://www.ncbi.nlm.nih.gov/pubmed/25386727
https://www.proquest.com/docview/1622355212
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https://pubmed.ncbi.nlm.nih.gov/PMC4241983
Volume 5
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