A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects

Background A formal single ascending and multiple dose pharmacokinetic (PK) trial of cannabidiol (CBD) oral solution was required to determine the safety and tolerability of CBD, the maximum tolerated dose, and to examine the effect of food on CBD PK parameters. Objective This trial assessed the saf...

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Vydáno v:	CNS drugs Ročník 32; číslo 11; s. 1053 - 1067
Hlavní autoři:	Taylor, Lesley, Gidal, Barry, Blakey, Graham, Tayo, Bola, Morrison, Gilmour
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cham Springer International Publishing 01.11.2018
Témata:	Administration, Oral Cannabidiol - administration & dosage Cannabidiol - adverse effects Cannabidiol - pharmacokinetics Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Female Food-Drug Interactions Half-Life Healthy Volunteers Humans Male Medicine Medicine & Public Health Neurology Neurosciences Original Original Research Article Pharmacotherapy Psychiatry Psychopharmacology Young Adult
ISSN:	1172-7047, 1179-1934, 1179-1934
On-line přístup:	Získat plný text
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