(E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide protecting rat heart tissues from isoproterenol toxicity: Evidence from in vitro and in vivo tests
The current study was aimed to assess the protective effect of a new molecule (E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide, denoted 1c, against cardiac remodeling process in isoproterenol (Isop) induced myocardial infarction (MI) in rats. Male Wistar rats were randomly divided...
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| Published in: | European journal of pharmacology Vol. 881; p. 173137 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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15.08.2020
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| ISSN: | 0014-2999, 1879-0712, 1879-0712, 0014-2999 |
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| Abstract | The current study was aimed to assess the protective effect of a new molecule (E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide, denoted 1c, against cardiac remodeling process in isoproterenol (Isop) induced myocardial infarction (MI) in rats. Male Wistar rats were randomly divided into four groups, control, Isop (85 mg/kg body weight was injected subcutaneously into rats at an interval of 24 h for 2 days (6th and 7th day) to induce MI and pretreated animals with acenocoumarol (Ace) (150 μg/kg bw) and 1c (150 μg/kg bw) by oral administration during 7 days and injected with isoproterenol (Isop + Ace) and (Isop + 1c) groups. Results in vitro showed that 1c is endowed with potent inhibition of angiotensin-converting enzyme (ACE) with an IC50 39.12 μg/ml. The in vivo exploration evidenced alteration in the ECG pattern, notable cardiac hypertrophy and increase in plasma level of fibrinogen, troponin-T, CK-MB and LDH, AST and ALT by 171%, 300%, 50%, 64% and 75% respectively with histological myocardium necrosis and cells inflammatory infiltration. However, pre-treatment with 1c improved the ECG pattern reduced significantly the cardiac dysfunction markers and ameliorated the thrombolytic process by decreasing fibrinogen level as compared to untreated infracted rats. Overall, (E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide 1c could be used as anticoagulant agent to prevent thrombosis in acute myocardial infarction.
[Display omitted]
•Synthesis of new (E)- N'-[1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene benzohydrazide 1c.•In vitro tests showed potent inhibition of angiotensine I-converting enzyme (ACE).•In vivo assays (on rats), pre-treatment with 1c improved the ECG pattern.•1c reduced the cardiac dysfunction markers and ameliorated the thrombolytic process. |
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| AbstractList | The current study was aimed to assess the protective effect of a new molecule (E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide, denoted 1c, against cardiac remodeling process in isoproterenol (Isop) induced myocardial infarction (MI) in rats. Male Wistar rats were randomly divided into four groups, control, Isop (85 mg/kg body weight was injected subcutaneously into rats at an interval of 24 h for 2 days (6th and 7th day) to induce MI and pretreated animals with acenocoumarol (Ace) (150 μg/kg bw) and 1c (150 μg/kg bw) by oral administration during 7 days and injected with isoproterenol (Isop + Ace) and (Isop + 1c) groups. Results in vitro showed that 1c is endowed with potent inhibition of angiotensin-converting enzyme (ACE) with an IC50 39.12 μg/ml. The in vivo exploration evidenced alteration in the ECG pattern, notable cardiac hypertrophy and increase in plasma level of fibrinogen, troponin-T, CK-MB and LDH, AST and ALT by 171%, 300%, 50%, 64% and 75% respectively with histological myocardium necrosis and cells inflammatory infiltration. However, pre-treatment with 1c improved the ECG pattern reduced significantly the cardiac dysfunction markers and ameliorated the thrombolytic process by decreasing fibrinogen level as compared to untreated infracted rats. Overall, (E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide 1c could be used as anticoagulant agent to prevent thrombosis in acute myocardial infarction.
[Display omitted]
•Synthesis of new (E)- N'-[1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene benzohydrazide 1c.•In vitro tests showed potent inhibition of angiotensine I-converting enzyme (ACE).•In vivo assays (on rats), pre-treatment with 1c improved the ECG pattern.•1c reduced the cardiac dysfunction markers and ameliorated the thrombolytic process. The current study was aimed to assess the protective effect of a new molecule (E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide, denoted 1c, against cardiac remodeling process in isoproterenol (Isop) induced myocardial infarction (MI) in rats. Male Wistar rats were randomly divided into four groups, control, Isop (85 mg/kg body weight was injected subcutaneously into rats at an interval of 24 h for 2 days (6 and 7 day) to induce MI and pretreated animals with acenocoumarol (Ace) (150 μg/kg bw) and 1c (150 μg/kg bw) by oral administration during 7 days and injected with isoproterenol (Isop + Ace) and (Isop + 1c) groups. Results in vitro showed that 1c is endowed with potent inhibition of angiotensin-converting enzyme (ACE) with an IC 39.12 μg/ml. The in vivo exploration evidenced alteration in the ECG pattern, notable cardiac hypertrophy and increase in plasma level of fibrinogen, troponin-T, CK-MB and LDH, AST and ALT by 171%, 300%, 50%, 64% and 75% respectively with histological myocardium necrosis and cells inflammatory infiltration. However, pre-treatment with 1c improved the ECG pattern reduced significantly the cardiac dysfunction markers and ameliorated the thrombolytic process by decreasing fibrinogen level as compared to untreated infracted rats. Overall, (E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide 1c could be used as anticoagulant agent to prevent thrombosis in acute myocardial infarction. The current study was aimed to assess the protective effect of a new molecule (E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide, denoted 1c, against cardiac remodeling process in isoproterenol (Isop) induced myocardial infarction (MI) in rats. Male Wistar rats were randomly divided into four groups, control, Isop (85 mg/kg body weight was injected subcutaneously into rats at an interval of 24 h for 2 days (6th and 7th day) to induce MI and pretreated animals with acenocoumarol (Ace) (150 μg/kg bw) and 1c (150 μg/kg bw) by oral administration during 7 days and injected with isoproterenol (Isop + Ace) and (Isop + 1c) groups. Results in vitro showed that 1c is endowed with potent inhibition of angiotensin-converting enzyme (ACE) with an IC50 39.12 μg/ml. The in vivo exploration evidenced alteration in the ECG pattern, notable cardiac hypertrophy and increase in plasma level of fibrinogen, troponin-T, CK-MB and LDH, AST and ALT by 171%, 300%, 50%, 64% and 75% respectively with histological myocardium necrosis and cells inflammatory infiltration. However, pre-treatment with 1c improved the ECG pattern reduced significantly the cardiac dysfunction markers and ameliorated the thrombolytic process by decreasing fibrinogen level as compared to untreated infracted rats. Overall, (E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide 1c could be used as anticoagulant agent to prevent thrombosis in acute myocardial infarction.The current study was aimed to assess the protective effect of a new molecule (E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide, denoted 1c, against cardiac remodeling process in isoproterenol (Isop) induced myocardial infarction (MI) in rats. Male Wistar rats were randomly divided into four groups, control, Isop (85 mg/kg body weight was injected subcutaneously into rats at an interval of 24 h for 2 days (6th and 7th day) to induce MI and pretreated animals with acenocoumarol (Ace) (150 μg/kg bw) and 1c (150 μg/kg bw) by oral administration during 7 days and injected with isoproterenol (Isop + Ace) and (Isop + 1c) groups. Results in vitro showed that 1c is endowed with potent inhibition of angiotensin-converting enzyme (ACE) with an IC50 39.12 μg/ml. The in vivo exploration evidenced alteration in the ECG pattern, notable cardiac hypertrophy and increase in plasma level of fibrinogen, troponin-T, CK-MB and LDH, AST and ALT by 171%, 300%, 50%, 64% and 75% respectively with histological myocardium necrosis and cells inflammatory infiltration. However, pre-treatment with 1c improved the ECG pattern reduced significantly the cardiac dysfunction markers and ameliorated the thrombolytic process by decreasing fibrinogen level as compared to untreated infracted rats. Overall, (E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide 1c could be used as anticoagulant agent to prevent thrombosis in acute myocardial infarction. The current study was aimed to assess the protective effect of a new molecule (E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide, denoted 1c, against cardiac remodeling process in isoproterenol (Isop) induced myocardial infarction (MI) in rats. Male Wistar rats were randomly divided into four groups, control, Isop (85 mg/kg body weight was injected subcutaneously into rats at an interval of 24 h for 2 days (6 and 7 day) to induce MI and pretreated animals with acenocoumarol (Ace) (150 μg/kg bw) and 1c (150 μg/kg bw) by oral administration during 7 days and injected with isoproterenol (Isop + Ace) and (Isop + 1c) groups. Results in vitro showed that 1c is endowed with potent inhibition of angiotensin-converting enzyme (ACE) with an IC 39.12 μg/ml. The in vivo exploration evidenced alteration in the ECG pattern, notable cardiac hypertrophy and increase in plasma level of fibrinogen, troponin-T, CK-MB and LDH, AST and ALT by 171%, 300%, 50%, 64% and 75% respectively with histological myocardium necrosis and cells inflammatory infiltration. However, pre-treatment with 1c improved the ECG pattern reduced significantly the cardiac dysfunction markers and ameliorated the thrombolytic process by decreasing fibrinogen level as compared to untreated infracted rats. Overall, (E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide 1c could be used as anticoagulant agent to prevent thrombosis in acute myocardial infarction. |
| ArticleNumber | 173137 |
| Author | Khdhiri, Emna Allouche, Noureddine Ghazouani, Lakhdar Ammar, Houcine Hajji, Raouf Abid, Souhir Feriani, Anouar Mnafgui, Kais Bouzanna, Walid Bazureau, Jean-Pierre |
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| Cites_doi | 10.1016/j.ejmech.2012.06.056 10.3390/molecules24061037 10.1016/j.jscs.2017.12.002 10.1016/j.bioorg.2018.06.005 10.1002/jhet.1733 10.1056/NEJMra1112570 10.3390/molecules21101322 10.1155/2015/624159 10.1107/S0108270104018323 10.1159/000205234 10.1016/j.rser.2014.07.106 10.1016/j.ejmech.2015.06.017 10.2174/1381612043382710 10.1007/s12012-015-9323-1 10.1016/j.biopha.2017.07.080 10.1016/j.ahj.2006.02.022 10.2174/1568011053352550 10.1016/S0021-9673(02)00052-3 10.1016/j.ijcard.2011.09.005 10.1016/j.arabjc.2017.05.007 10.1016/j.bmc.2017.01.037 10.2174/1389557516666160801094919 10.1007/s12291-013-0401-5 10.1182/blood-2010-11-316885 10.1016/j.ejmech.2019.07.003 10.1055/s-0043-119068 10.3109/15376516.2015.1053648 10.1016/j.bionut.2014.02.003 10.1007/s13105-016-0494-4 10.1186/1743-7075-11-52 10.1139/cjpp-2019-0085 10.3109/14756366.2014.995180 10.3390/molecules19022089 10.2165/00003088-200544120-00003 10.1016/j.bmcl.2013.07.009 10.2174/1573406412666160610093216 10.1007/s00894-011-1219-9 10.1016/j.etp.2017.06.004 10.1016/j.molstruc.2005.11.018 10.1002/cber.18980310308 10.1111/cbdd.12629 10.3109/14756366.2016.1163342 10.1056/NEJM199411103311907 10.1161/CIR.0000000000000485 10.1155/2013/197475 10.1016/j.plefa.2006.12.002 10.1134/S1070428009050030 10.1016/j.biopha.2018.05.005 |
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| Keywords | Myocardial infarction Thrombolytic ACE (E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide Isoproterenol E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide |
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| References | Sutton, John (bib53) 2000; 101 Ufer (bib55) 2005; 44 Chelucci, Dutra, Lopes Pires, De Melo, Bosquesi, Chung, Dos Santos (bib12) 2014; 19 Ershov, Lagoda, Yakimovich, Pakalnis, Zerova, Dobrodumov, Shamanin (bib19) 2009; 45 Knoevenagel (bib35) 1898; 31 Kovvuri, Nagaraju, Ganesh Kumar, Sirisha, Chandrasekhar, Alarifi, Kamal (bib33) 2018; 22 Kirsch, Abdelwahab, Chaimbault (bib31) 2016; 21 Chekir, Debbabi, Regazzetti, Dargère, Laprévote, Ben Jannet, Gharbi (bib10) 2018; 80 Jameel, Umar, Kumar, Hoda (bib27) 2016; 87 Keri, S, Nagaraja, Santos (bib28) 2015; 100 Sahu, Chakraborty, Sarkar (bib49) 2014; 39 Elias, Benhamou, Jaber, Dorot, Zada, Oved, Pichinuk, Fridman (bib20) 2019; 179 Shukla, Sharma, Singh (bib51) 2015; 30 Filali, Belkacem, Nejma, Souchard, Jannet, Bouajila (bib22) 2016; 31 Pari, Rajarajeswari, Saravanan, Rathinam (bib42) 2014; 4 Ghazouani, Khdhiri, Elmufti, Feriani, Tir, Baaziz, Hajji, Ben Mansour, Ammar, Abid, Mnafgui (bib24) 2019; 97 Daoud, Mnafgui, Turki, Jmal, Ayadi, ElFeki, Gharsallah (bib16) 2017; 69 Ahsan, Ahad, Iqbal, Siddiqui (bib3) 2014; 11 Khan, Hassan, Akhtar, Najmi (bib30) 2018; 68 Destaing (bib17) 1960; 8 Dong, Shi, Chen, Chen, Jiang, Liu, Hong (bib18) 2014; 51 Fylaktakidou, Hadjipavlou-Litina, Litinas, Nicolaides (bib21) 2014; 10 Mnafgui, Khdhiri, Ghazouani, Ncir, Zaafouri, Allouche, Elfeki, Ammar, Abid, Hajji (bib40) 2019; 1–14 Wu, Aluko, Muir (bib57) 2002; 950 Patorski, Wyrzykiewicz, Bartkowiak (bib45) 2013 Nabel, Braunwal (bib41) 2012; 366 Danesh, Lewington, Thompson, Lowe, Collins, Kostis (bib15) 2005; 294 Leal, Pereira, Kümmerle, Leal, Tesch, de Sant'Anna, Fraga, Barreiro, Sudo, Zapata-Sudo (bib36) 2012; 55 bib56 Borghi, Bacchelli, Esposti, Ambrosioni (bib9) 2006; 152 Paula, Das, Tanvir, Hossen, Saha, Afroz (bib43) 2017; 94 Paracatu, Zeraik, de Carvalho Bertozo, de Andrade Bartolomeu, da Silva Filho, da Fonseca, Ximenes, V (bib44) 2017; 13 Gonzaga, Silva, Ferreira, Wardell, Wardell (bib26) 2016; 27 Pintus, Matos, Vilar, Hripcsak, Varela, Uriarte, Santana, Borges, Medda, Di Petrillo, Era, Fais (bib47) 2017; 25 Saravanan, Ponmurugan, Sathiyavathi, Vadivukkarasi, Sengottuvelu (bib50) 2013; 165 Pérez-Cruz, Moncada-Basualto, Morales-Valenzuela, Barriga-González, Navarrete-Encina, Núñez-Vergara, Olea-Azar (bib46) 2018; 11 Mnafgui, Hajji, Derbali, Khlif, Kraiem, Ellefi, Gharsallah (bib39) 2016; 16 Border, Noble (bib8) 1994; 331 Ramya, Anusha, Monica Anita, Rajadurai (bib48) 2014; 9 Kostova (bib34) 2005; 5 Attalla, Ahmed, Zaki, Khattab (bib5) 2018; 104 Gagliotti Vigil de Mello, Frode (bib23) 2018; vol. 25 Benjamin, Blaha, Chiuve, Cushman, Das, Deo, Muntner (bib6) 2017; 135 Conti, Morigi, Locatelli, Rambaldi, Bua, Gallinella, Leoni (bib14) 2019; 24 Abdallah, Znati, Regazzetti, Dargère, Laprévote, Jannet, Gharbi (bib1) 2017; 192 Chen, Li, Yao, Zhou, Zhao, Gu, Wang, Li (bib11) 2013; 23 Srikrishna, Godugu, Dubey (bib52) 2018; 18 Braga, Alves, Fraga, Barreiro, de Oliveira, Andrade (bib7) 2012; 18 Machlus, Cardenas, Church, Wolberg (bib37) 2011; 117 Syakaev, Podyachev, Buzykin, Latypov, Habicher, Konovalov (bib54) 2006; 788 Kontogiorgis, Nicolotti, Mangiatordi, Tognolini, Karalaki, Giorgio, Patsilinakos, Carotti, Hadjipavlou-Litina, Barocelli (bib32) 2015; 30 Glidewell, Low, Skakle, Wardell (bib25) 2004; C60 Mnafgui, Khlif, Hajji, Derbali, Kraiem, Ellefi, Michel, Halabalaki, Skaltsounis, Elfeki, Gharsallah, Allouche (bib38) 2015; 25 Abbas (bib2) 2016; 72 Anandan, Mathew, Sankar, Viswanathan (bib4) 2007; 76 Clauss (bib13) 1957; 17 Khalil, Ahmmed, Ahmed, Tanvir, Afroz, Paul (bib29) 2015 Khalil (10.1016/j.ejphar.2020.173137_bib29) 2015 Kontogiorgis (10.1016/j.ejphar.2020.173137_bib32) 2015; 30 Dong (10.1016/j.ejphar.2020.173137_bib18) 2014; 51 Abdallah (10.1016/j.ejphar.2020.173137_bib1) 2017; 192 Ghazouani (10.1016/j.ejphar.2020.173137_bib24) 2019; 97 Saravanan (10.1016/j.ejphar.2020.173137_bib50) 2013; 165 Mnafgui (10.1016/j.ejphar.2020.173137_bib40) 2019; 1–14 Sutton (10.1016/j.ejphar.2020.173137_bib53) 2000; 101 Glidewell (10.1016/j.ejphar.2020.173137_bib25) 2004; C60 Sahu (10.1016/j.ejphar.2020.173137_bib49) 2014; 39 Jameel (10.1016/j.ejphar.2020.173137_bib27) 2016; 87 Clauss (10.1016/j.ejphar.2020.173137_bib13) 1957; 17 Pari (10.1016/j.ejphar.2020.173137_bib42) 2014; 4 Nabel (10.1016/j.ejphar.2020.173137_bib41) 2012; 366 Gonzaga (10.1016/j.ejphar.2020.173137_bib26) 2016; 27 Kostova (10.1016/j.ejphar.2020.173137_bib34) 2005; 5 Chen (10.1016/j.ejphar.2020.173137_bib11) 2013; 23 Destaing (10.1016/j.ejphar.2020.173137_bib17) 1960; 8 Leal (10.1016/j.ejphar.2020.173137_bib36) 2012; 55 Patorski (10.1016/j.ejphar.2020.173137_bib45) 2013 Srikrishna (10.1016/j.ejphar.2020.173137_bib52) 2018; 18 Gagliotti Vigil de Mello (10.1016/j.ejphar.2020.173137_bib23) 2018; vol. 25 Keri (10.1016/j.ejphar.2020.173137_bib28) 2015; 100 Paracatu (10.1016/j.ejphar.2020.173137_bib44) 2017; 13 Paula (10.1016/j.ejphar.2020.173137_bib43) 2017; 94 Knoevenagel (10.1016/j.ejphar.2020.173137_bib35) 1898; 31 Fylaktakidou (10.1016/j.ejphar.2020.173137_bib21) 2014; 10 Borghi (10.1016/j.ejphar.2020.173137_bib9) 2006; 152 Kovvuri (10.1016/j.ejphar.2020.173137_bib33) 2018; 22 Khan (10.1016/j.ejphar.2020.173137_bib30) 2018; 68 Ahsan (10.1016/j.ejphar.2020.173137_bib3) 2014; 11 Border (10.1016/j.ejphar.2020.173137_bib8) 1994; 331 Conti (10.1016/j.ejphar.2020.173137_bib14) 2019; 24 Braga (10.1016/j.ejphar.2020.173137_bib7) 2012; 18 Pintus (10.1016/j.ejphar.2020.173137_bib47) 2017; 25 Elias (10.1016/j.ejphar.2020.173137_bib20) 2019; 179 Ramya (10.1016/j.ejphar.2020.173137_bib48) 2014; 9 Machlus (10.1016/j.ejphar.2020.173137_bib37) 2011; 117 Wu (10.1016/j.ejphar.2020.173137_bib57) 2002; 950 Ershov (10.1016/j.ejphar.2020.173137_bib19) 2009; 45 Pérez-Cruz (10.1016/j.ejphar.2020.173137_bib46) 2018; 11 Anandan (10.1016/j.ejphar.2020.173137_bib4) 2007; 76 Chekir (10.1016/j.ejphar.2020.173137_bib10) 2018; 80 Chelucci (10.1016/j.ejphar.2020.173137_bib12) 2014; 19 Mnafgui (10.1016/j.ejphar.2020.173137_bib39) 2016; 16 Kirsch (10.1016/j.ejphar.2020.173137_bib31) 2016; 21 Shukla (10.1016/j.ejphar.2020.173137_bib51) 2015; 30 Abbas (10.1016/j.ejphar.2020.173137_bib2) 2016; 72 Benjamin (10.1016/j.ejphar.2020.173137_bib6) 2017; 135 Attalla (10.1016/j.ejphar.2020.173137_bib5) 2018; 104 Filali (10.1016/j.ejphar.2020.173137_bib22) 2016; 31 Ufer (10.1016/j.ejphar.2020.173137_bib55) 2005; 44 Daoud (10.1016/j.ejphar.2020.173137_bib16) 2017; 69 Syakaev (10.1016/j.ejphar.2020.173137_bib54) 2006; 788 Danesh (10.1016/j.ejphar.2020.173137_bib15) 2005; 294 Mnafgui (10.1016/j.ejphar.2020.173137_bib38) 2015; 25 |
| References_xml | – volume: 179 start-page: 779 year: 2019 end-page: 790 ident: bib20 article-title: Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles publication-title: Eur. J. Med. Chem. – volume: 101 start-page: 2981 year: 2000 end-page: 2988 ident: bib53 article-title: Sharpe, left ventricular remodeling after myocardial infarction publication-title: Pathophysiol. Ther. – volume: 30 start-page: 925 year: 2015 end-page: 933 ident: bib32 article-title: Studies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives publication-title: J. Enzym. Inhib. Med. Chem. – volume: 94 start-page: 256 year: 2017 end-page: 264 ident: bib43 article-title: Protective effects of ethanolic peel and pulp extracts of publication-title: Biomed. Pharmacother. – volume: 44 start-page: 1227 year: 2005 end-page: 1246 ident: bib55 article-title: Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol publication-title: Clin. Pharmacokinet. – volume: 135 start-page: e146 year: 2017 end-page: e603 ident: bib6 article-title: Heart disease and stroke statistics 2017 up-date: a report from the American Heart Association publication-title: Circulation – ident: bib56 article-title: Fact sheet N°290, World Health statistics 2011 – volume: 13 start-page: 93 year: 2017 end-page: 100 ident: bib44 article-title: Synthesis, antioxidant and anti-inflammatory properties of an apocynin- derived dihydrocoumarin publication-title: Mini Rev. Med. Chem. – volume: 18 start-page: 113 year: 2018 end-page: 141 ident: bib52 article-title: A review on pharmacological properties of coumarins publication-title: Mini Rev. Med. Chem. – volume: 31 start-page: 2596 year: 1898 end-page: 2619 ident: bib35 article-title: Condensation von malonsäure mit aromatischen aldehyden durch ammoniak und amine publication-title: Chem. Ber. – volume: 5 start-page: 29 year: 2005 end-page: 46 ident: bib34 article-title: Synthetic and natural coumarins as cytotoxic agents publication-title: Curr. Med. Chem. Anticancer Agents – volume: 104 start-page: 542 year: 2018 end-page: 549 ident: bib5 article-title: Paradoxical effects of atorvastatin in isoproterenol-induced cardiotoxicity in rats: role of oxidative stress and inflammation publication-title: Biomed. Pharmacother. – volume: 117 start-page: 4953 year: 2011 end-page: 4963 ident: bib37 article-title: Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice publication-title: Blood – volume: 39 start-page: 575 year: 2014 end-page: 586 ident: bib49 article-title: Coal-biomass co-combustion: an overview publication-title: Renew. Sustain. Energy Rev. – volume: 72 start-page: 469 year: 2016 end-page: 484 ident: bib2 article-title: Cardioprotective effect of resveratrol analogue isorhapontigenin versus omega-3 fatty acids in isoproterenol-induced myocardial infarction in rats publication-title: J. Physiol. Biochem. – volume: 11 start-page: 52 year: 2014 end-page: 74 ident: bib3 article-title: Pharmacological potential of tocotrienols: a review publication-title: Nutr. Metab. – volume: 51 start-page: 1844 year: 2014 end-page: 1848 ident: bib18 article-title: Synthesis of 1,5-benzodiazepine derivatives containing 1,2,3-triazole moiety publication-title: J. Heterocycl. Chem. – volume: 68 start-page: 139 year: 2018 end-page: 145 ident: bib30 article-title: Renin inhibition by aliskiren protects rats against isoproterenol induced myocardial infarction publication-title: Drug Res. – start-page: 1 year: 2013 end-page: 12 ident: bib45 article-title: Synthesis and conformational assignment of publication-title: J. Spectroscopy – volume: 11 start-page: 525 year: 2018 end-page: 537 ident: bib46 article-title: Synthesis and antioxidant study of new polyphenolic hybrid-coumarins publication-title: Arabian J. Chem. – volume: vol. 25 start-page: 1446 year: 2018 end-page: 1476 ident: bib23 publication-title: and – volume: 294 start-page: 1799 year: 2005 end-page: 1809 ident: bib15 article-title: Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis publication-title: J. Am. Med. Assoc. – volume: 25 start-page: 538 year: 2015 end-page: 546 ident: bib38 article-title: Preventive effects of oleuropein against cardiac remodeling after cardiac infarction in Wistar rat through inhibiting angiotensin-converting enzyme activity publication-title: Toxicol. Mech. Methods – year: 2015 ident: bib29 article-title: Amelioration of isoproterenol-induced oxidative damage in rat myocardium by Withania somnifera leaf extract publication-title: Biomed Res. Internat. – volume: 55 start-page: 49 year: 2012 end-page: 57 ident: bib36 article-title: Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor publication-title: Eur. J. Med. Chem. – volume: 31 start-page: 23 year: 2016 end-page: 33 ident: bib22 article-title: Synthesis, cytotoxic, anti-lipoxygenase and anti-acetylcholinesterase capacities of novel derivatives from harmine publication-title: J. Enzym. Inhib. Med. Chem. – volume: 97 start-page: 989 year: 2019 end-page: 998 ident: bib24 article-title: Cardioprotective effects of ( publication-title: Can. J. Physiol. Pharmacol. – volume: 366 start-page: 54 year: 2012 end-page: 63 ident: bib41 article-title: Tale of coronary artery disease and myocardial infarction publication-title: N. Engl. J. Med. – volume: 4 start-page: 171 year: 2014 end-page: 176 ident: bib42 article-title: Antihyperlipidemic effect of coumarin in experimental type 2 diabetic rats publication-title: Biomed. Prevent. Nutri. – volume: 16 start-page: 147 year: 2016 end-page: 155 ident: bib39 article-title: Protective effect of hydroxytyrosol against cardiac remodeling after isoproterenol-induced myocardial infarction in rat publication-title: Cardiovasc. Toxicol. – volume: 192 start-page: 835 year: 2017 end-page: 844 ident: bib1 article-title: Synthesis of S-mono- and S,O-bis-1,2,3-triazole linked 1,5-benzodiazepine conjugates and evaluation of their cytotoxic, anti-tyrosinase, and anti-cholinesterase activities. Phosphorus, Sulfur Silicon Relat publication-title: Elements – volume: 331 start-page: 1286 year: 1994 end-page: 1292 ident: bib8 article-title: Transforming growth factor β in tissue fibrosis publication-title: N. Engl. J. Med. – volume: 27 start-page: 2322 year: 2016 end-page: 2333 ident: bib26 article-title: Crystal structures of 1-aryl-1 publication-title: J. Braz. Chem. Soc. – volume: 9 start-page: 675 year: 2014 end-page: 677 ident: bib48 article-title: Rapid molecular detection of publication-title: Asian J. Microbiol. Biotechnol. Environ. Sci. – volume: 10 start-page: 3813 year: 2014 end-page: 3833 ident: bib21 article-title: Natural and synthetic coumarin derivatives with anti-inflammatory/antioxidant activities publication-title: Curr. Pharmaceut. Des. – volume: 950 start-page: 125 year: 2002 end-page: 130 ident: bib57 article-title: Improved method for direct high-performance liquid chromatography assay of angiotensin-converting enzyme-catalyzed reactions publication-title: J. Chromatogr. – volume: 45 start-page: 660 year: 2009 end-page: 661 ident: bib19 article-title: Tautomerism and conformational isomerism of mercaptoacetylhydrazones of aliphatic and aromatic aldehydes publication-title: Russ. J. Org. Chem. – volume: 30 start-page: 27 year: 2015 end-page: 34 ident: bib51 article-title: β-Adrenoreceptor agonist Isoproterenol alters oxidative status, inflammatory signaling, injury markers and apoptotic cell death in myocardium of rats publication-title: Indian J. Clin. Biochem. – volume: 69 start-page: 656 year: 2017 end-page: 665 ident: bib16 article-title: Cardiopreventive effect of ethanolic extract of Date Palm Pollen against isoproterenol induced myocardial infarction in rats through the inhibition of the angiotensin-converting enzyme publication-title: Exp. Toxicol. Pathol. – volume: 76 start-page: 153 year: 2007 end-page: 158 ident: bib4 article-title: Protective effect of n-3 polyunsaturated fatty acids concentrate on isoproterenol induced myocardial infarction in rats publication-title: Prostaglandins Leukot. Essent. Fatty Acids – volume: 100 start-page: 257 year: 2015 end-page: 269 ident: bib28 article-title: Recent progress in the drug development of coumarin derivatives as potent antituberculosis agents publication-title: Eur. J. Med. Chem. – volume: 8 start-page: 1615 year: 1960 end-page: 1621 ident: bib17 article-title: Determination of fibrinogen by the Von Clauss coagulation micromethod publication-title: Pathol. Biol. – volume: 21 start-page: 1322 year: 2016 end-page: 1335 ident: bib31 article-title: Natural and synthetic coumarins with effects on inflammation publication-title: Molecules – volume: 22 start-page: 665 year: 2018 end-page: 677 ident: bib33 article-title: Catalyst-free synthesis of pyrazole-aniline linked coumarin derivatives and their antimicrobial evaluation publication-title: J. Saudi Chem. Soc. – volume: 25 start-page: 1687 year: 2017 end-page: 1695 ident: bib47 article-title: New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: anti-melanogenesis and antioxidant activities, and computational molecular modeling studies publication-title: Bioorg. Med. Chem. – volume: 23 start-page: 4785 year: 2013 end-page: 4789 ident: bib11 article-title: Design, synthesis, and anti-tumor activities of novel triphenylethylene-coumarin hybrids, and their interactions with Ct-DNA publication-title: Bioorg. Med. Chem. Lett – volume: 17 start-page: 237 year: 1957 end-page: 246 ident: bib13 article-title: Rapid physiological coagulation method in determination of fibrinogen publication-title: Acta Haematol. – volume: 18 start-page: 2065 year: 2012 end-page: 2078 ident: bib7 article-title: Combination of docking, molecular dynamics and quantum mechanical calculations for metabolism prediction of 3,4-methylenedioxybenzoyl-2-thienylhydrazone publication-title: J. Mol. Model. – volume: 87 start-page: 21 year: 2016 end-page: 38 ident: bib27 article-title: Coumarin: a Privileged scaffold for the design and development of antineurodegenerative agents publication-title: Chem. Biol. Drug Des. – volume: C60 start-page: o686 year: 2004 end-page: o689 ident: bib25 article-title: Hydrogen bonding in 2-nitrobenzaldehyde hydrazones and a three-dimensional hydrogen-bonded framework in 3-nitrobenzaldehyde hydrazone publication-title: Acta Crystallogr. Sect. C Cryst. Struct. Commun. – volume: 788 start-page: 55 year: 2006 end-page: 62 ident: bib54 article-title: NMR study of conformation and isomerization of aryl- and hetero arylaldehyde 4- publication-title: J. Mol. Struct. – volume: 19 start-page: 2089 year: 2014 end-page: 2099 ident: bib12 article-title: Antiplatelet and Antithrombotic Activities of non-steroidal anti-inflammatory drugs containing an publication-title: Molecules – volume: 165 start-page: 494 year: 2013 end-page: 498 ident: bib50 article-title: Cardioprotective activity of publication-title: Int. J. Cardiol. – volume: 80 start-page: 189 year: 2018 end-page: 194 ident: bib10 article-title: Design, synthesis and biological evaluation of novel 1,2,3-triazole linked coumarinopyrazole conjugates as potent anti-cholinesterase, anti-5-lipoxygenase, anti-tyrosinase and anti-cancer agents publication-title: Bioorg. Chem. – volume: 1–14 year: 2019 ident: bib40 article-title: Anti-embolic and anti-oxidative effects of a novel ( publication-title: Arch. Physiol. Biochem. – volume: 152 start-page: 470 year: 2006 end-page: 477 ident: bib9 article-title: Effects of early angiotensin-converting enzyme inhibition in patients with non-ST-elevation acute anterior myocardial infarction publication-title: Am. Heart J. – volume: 24 start-page: 1037 year: 2019 end-page: 1052 ident: bib14 article-title: Synthesis of 3-(imidazo[2,1-b]thiazol-6-yl)-2 publication-title: Molecules – volume: 55 start-page: 49 year: 2012 ident: 10.1016/j.ejphar.2020.173137_bib36 article-title: Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2012.06.056 – volume: 24 start-page: 1037 year: 2019 ident: 10.1016/j.ejphar.2020.173137_bib14 article-title: Synthesis of 3-(imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one derivatives and study of their antiviral activity against parvovirus B19 publication-title: Molecules doi: 10.3390/molecules24061037 – volume: 22 start-page: 665 year: 2018 ident: 10.1016/j.ejphar.2020.173137_bib33 article-title: Catalyst-free synthesis of pyrazole-aniline linked coumarin derivatives and their antimicrobial evaluation publication-title: J. Saudi Chem. Soc. doi: 10.1016/j.jscs.2017.12.002 – volume: 80 start-page: 189 year: 2018 ident: 10.1016/j.ejphar.2020.173137_bib10 article-title: Design, synthesis and biological evaluation of novel 1,2,3-triazole linked coumarinopyrazole conjugates as potent anti-cholinesterase, anti-5-lipoxygenase, anti-tyrosinase and anti-cancer agents publication-title: Bioorg. Chem. doi: 10.1016/j.bioorg.2018.06.005 – volume: 51 start-page: 1844 year: 2014 ident: 10.1016/j.ejphar.2020.173137_bib18 article-title: Synthesis of 1,5-benzodiazepine derivatives containing 1,2,3-triazole moiety via 1,3-dipolar cycloaddition reaction publication-title: J. Heterocycl. Chem. doi: 10.1002/jhet.1733 – volume: 366 start-page: 54 year: 2012 ident: 10.1016/j.ejphar.2020.173137_bib41 article-title: Tale of coronary artery disease and myocardial infarction publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra1112570 – volume: 21 start-page: 1322 year: 2016 ident: 10.1016/j.ejphar.2020.173137_bib31 article-title: Natural and synthetic coumarins with effects on inflammation publication-title: Molecules doi: 10.3390/molecules21101322 – year: 2015 ident: 10.1016/j.ejphar.2020.173137_bib29 article-title: Amelioration of isoproterenol-induced oxidative damage in rat myocardium by Withania somnifera leaf extract publication-title: Biomed Res. Internat. doi: 10.1155/2015/624159 – volume: C60 start-page: o686 year: 2004 ident: 10.1016/j.ejphar.2020.173137_bib25 article-title: Hydrogen bonding in 2-nitrobenzaldehyde hydrazones and a three-dimensional hydrogen-bonded framework in 3-nitrobenzaldehyde hydrazone publication-title: Acta Crystallogr. Sect. C Cryst. Struct. Commun. doi: 10.1107/S0108270104018323 – volume: 17 start-page: 237 year: 1957 ident: 10.1016/j.ejphar.2020.173137_bib13 article-title: Rapid physiological coagulation method in determination of fibrinogen publication-title: Acta Haematol. doi: 10.1159/000205234 – volume: 1–14 year: 2019 ident: 10.1016/j.ejphar.2020.173137_bib40 article-title: Anti-embolic and anti-oxidative effects of a novel (E)-4-amino-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide against isoproterenol and vitamin-K induced ischemic stroke publication-title: Arch. Physiol. Biochem. – volume: 39 start-page: 575 year: 2014 ident: 10.1016/j.ejphar.2020.173137_bib49 article-title: Coal-biomass co-combustion: an overview publication-title: Renew. Sustain. Energy Rev. doi: 10.1016/j.rser.2014.07.106 – volume: vol. 25 start-page: 1446 year: 2018 ident: 10.1016/j.ejphar.2020.173137_bib23 – volume: 100 start-page: 257 year: 2015 ident: 10.1016/j.ejphar.2020.173137_bib28 article-title: Recent progress in the drug development of coumarin derivatives as potent antituberculosis agents publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2015.06.017 – volume: 10 start-page: 3813 year: 2014 ident: 10.1016/j.ejphar.2020.173137_bib21 article-title: Natural and synthetic coumarin derivatives with anti-inflammatory/antioxidant activities publication-title: Curr. Pharmaceut. Des. doi: 10.2174/1381612043382710 – volume: 16 start-page: 147 year: 2016 ident: 10.1016/j.ejphar.2020.173137_bib39 article-title: Protective effect of hydroxytyrosol against cardiac remodeling after isoproterenol-induced myocardial infarction in rat publication-title: Cardiovasc. Toxicol. doi: 10.1007/s12012-015-9323-1 – volume: 94 start-page: 256 year: 2017 ident: 10.1016/j.ejphar.2020.173137_bib43 article-title: Protective effects of ethanolic peel and pulp extracts of Citrus macroptera fruit against isoproterenol-induced myocardial infarction in rats publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2017.07.080 – volume: 152 start-page: 470 year: 2006 ident: 10.1016/j.ejphar.2020.173137_bib9 article-title: Effects of early angiotensin-converting enzyme inhibition in patients with non-ST-elevation acute anterior myocardial infarction publication-title: Am. Heart J. doi: 10.1016/j.ahj.2006.02.022 – volume: 5 start-page: 29 year: 2005 ident: 10.1016/j.ejphar.2020.173137_bib34 article-title: Synthetic and natural coumarins as cytotoxic agents publication-title: Curr. Med. Chem. Anticancer Agents doi: 10.2174/1568011053352550 – volume: 950 start-page: 125 year: 2002 ident: 10.1016/j.ejphar.2020.173137_bib57 article-title: Improved method for direct high-performance liquid chromatography assay of angiotensin-converting enzyme-catalyzed reactions publication-title: J. Chromatogr. doi: 10.1016/S0021-9673(02)00052-3 – volume: 165 start-page: 494 year: 2013 ident: 10.1016/j.ejphar.2020.173137_bib50 article-title: Cardioprotective activity of Amaranthus viridis Linn: effect on serum marker enzymes, cardiac troponin and antioxidant system in experimental myocardial infarcted rats publication-title: Int. J. Cardiol. doi: 10.1016/j.ijcard.2011.09.005 – volume: 8 start-page: 1615 year: 1960 ident: 10.1016/j.ejphar.2020.173137_bib17 article-title: Determination of fibrinogen by the Von Clauss coagulation micromethod publication-title: Pathol. Biol. – volume: 27 start-page: 2322 year: 2016 ident: 10.1016/j.ejphar.2020.173137_bib26 article-title: Crystal structures of 1-aryl-1H- and 2-aryl-2H-1,2,3-triazolyl hydrazones, conformational consequences of different classical hydrogen bonds publication-title: J. Braz. Chem. Soc. – volume: 11 start-page: 525 year: 2018 ident: 10.1016/j.ejphar.2020.173137_bib46 article-title: Synthesis and antioxidant study of new polyphenolic hybrid-coumarins publication-title: Arabian J. Chem. doi: 10.1016/j.arabjc.2017.05.007 – volume: 25 start-page: 1687 year: 2017 ident: 10.1016/j.ejphar.2020.173137_bib47 article-title: New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: anti-melanogenesis and antioxidant activities, and computational molecular modeling studies publication-title: Bioorg. Med. Chem. doi: 10.1016/j.bmc.2017.01.037 – volume: 18 start-page: 113 year: 2018 ident: 10.1016/j.ejphar.2020.173137_bib52 article-title: A review on pharmacological properties of coumarins publication-title: Mini Rev. Med. Chem. doi: 10.2174/1389557516666160801094919 – volume: 30 start-page: 27 year: 2015 ident: 10.1016/j.ejphar.2020.173137_bib51 article-title: β-Adrenoreceptor agonist Isoproterenol alters oxidative status, inflammatory signaling, injury markers and apoptotic cell death in myocardium of rats publication-title: Indian J. Clin. Biochem. doi: 10.1007/s12291-013-0401-5 – volume: 117 start-page: 4953 year: 2011 ident: 10.1016/j.ejphar.2020.173137_bib37 article-title: Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice publication-title: Blood doi: 10.1182/blood-2010-11-316885 – volume: 294 start-page: 1799 year: 2005 ident: 10.1016/j.ejphar.2020.173137_bib15 article-title: Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis publication-title: J. Am. Med. Assoc. – volume: 179 start-page: 779 year: 2019 ident: 10.1016/j.ejphar.2020.173137_bib20 article-title: Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2019.07.003 – volume: 68 start-page: 139 year: 2018 ident: 10.1016/j.ejphar.2020.173137_bib30 article-title: Renin inhibition by aliskiren protects rats against isoproterenol induced myocardial infarction publication-title: Drug Res. doi: 10.1055/s-0043-119068 – volume: 25 start-page: 538 year: 2015 ident: 10.1016/j.ejphar.2020.173137_bib38 article-title: Preventive effects of oleuropein against cardiac remodeling after cardiac infarction in Wistar rat through inhibiting angiotensin-converting enzyme activity publication-title: Toxicol. Mech. Methods doi: 10.3109/15376516.2015.1053648 – volume: 4 start-page: 171 year: 2014 ident: 10.1016/j.ejphar.2020.173137_bib42 article-title: Antihyperlipidemic effect of coumarin in experimental type 2 diabetic rats publication-title: Biomed. Prevent. Nutri. doi: 10.1016/j.bionut.2014.02.003 – volume: 72 start-page: 469 year: 2016 ident: 10.1016/j.ejphar.2020.173137_bib2 article-title: Cardioprotective effect of resveratrol analogue isorhapontigenin versus omega-3 fatty acids in isoproterenol-induced myocardial infarction in rats publication-title: J. Physiol. Biochem. doi: 10.1007/s13105-016-0494-4 – volume: 11 start-page: 52 year: 2014 ident: 10.1016/j.ejphar.2020.173137_bib3 article-title: Pharmacological potential of tocotrienols: a review publication-title: Nutr. Metab. doi: 10.1186/1743-7075-11-52 – volume: 97 start-page: 989 year: 2019 ident: 10.1016/j.ejphar.2020.173137_bib24 article-title: Cardioprotective effects of (E)-4-hydroxy-N′-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide: a newly synthesized coumarin hydrazone against isoproterenol-induced myocardial infarction in a rat model publication-title: Can. J. Physiol. Pharmacol. doi: 10.1139/cjpp-2019-0085 – volume: 30 start-page: 925 year: 2015 ident: 10.1016/j.ejphar.2020.173137_bib32 article-title: Studies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives publication-title: J. Enzym. Inhib. Med. Chem. doi: 10.3109/14756366.2014.995180 – volume: 19 start-page: 2089 year: 2014 ident: 10.1016/j.ejphar.2020.173137_bib12 article-title: Antiplatelet and Antithrombotic Activities of non-steroidal anti-inflammatory drugs containing an N-acyl hydrazone subunit publication-title: Molecules doi: 10.3390/molecules19022089 – volume: 44 start-page: 1227 year: 2005 ident: 10.1016/j.ejphar.2020.173137_bib55 article-title: Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol publication-title: Clin. Pharmacokinet. doi: 10.2165/00003088-200544120-00003 – volume: 192 start-page: 835 year: 2017 ident: 10.1016/j.ejphar.2020.173137_bib1 article-title: Synthesis of S-mono- and S,O-bis-1,2,3-triazole linked 1,5-benzodiazepine conjugates and evaluation of their cytotoxic, anti-tyrosinase, and anti-cholinesterase activities. Phosphorus, Sulfur Silicon Relat publication-title: Elements – volume: 23 start-page: 4785 year: 2013 ident: 10.1016/j.ejphar.2020.173137_bib11 article-title: Design, synthesis, and anti-tumor activities of novel triphenylethylene-coumarin hybrids, and their interactions with Ct-DNA publication-title: Bioorg. Med. Chem. Lett doi: 10.1016/j.bmcl.2013.07.009 – volume: 13 start-page: 93 year: 2017 ident: 10.1016/j.ejphar.2020.173137_bib44 article-title: Synthesis, antioxidant and anti-inflammatory properties of an apocynin- derived dihydrocoumarin publication-title: Mini Rev. Med. Chem. doi: 10.2174/1573406412666160610093216 – volume: 101 start-page: 2981 year: 2000 ident: 10.1016/j.ejphar.2020.173137_bib53 article-title: Sharpe, left ventricular remodeling after myocardial infarction publication-title: Pathophysiol. Ther. – volume: 18 start-page: 2065 year: 2012 ident: 10.1016/j.ejphar.2020.173137_bib7 article-title: Combination of docking, molecular dynamics and quantum mechanical calculations for metabolism prediction of 3,4-methylenedioxybenzoyl-2-thienylhydrazone publication-title: J. Mol. Model. doi: 10.1007/s00894-011-1219-9 – volume: 69 start-page: 656 year: 2017 ident: 10.1016/j.ejphar.2020.173137_bib16 article-title: Cardiopreventive effect of ethanolic extract of Date Palm Pollen against isoproterenol induced myocardial infarction in rats through the inhibition of the angiotensin-converting enzyme publication-title: Exp. Toxicol. Pathol. doi: 10.1016/j.etp.2017.06.004 – volume: 788 start-page: 55 year: 2006 ident: 10.1016/j.ejphar.2020.173137_bib54 article-title: NMR study of conformation and isomerization of aryl- and hetero arylaldehyde 4-tert butylphenoxyacetylhydrazones publication-title: J. Mol. Struct. doi: 10.1016/j.molstruc.2005.11.018 – volume: 31 start-page: 2596 year: 1898 ident: 10.1016/j.ejphar.2020.173137_bib35 article-title: Condensation von malonsäure mit aromatischen aldehyden durch ammoniak und amine publication-title: Chem. Ber. doi: 10.1002/cber.18980310308 – volume: 87 start-page: 21 year: 2016 ident: 10.1016/j.ejphar.2020.173137_bib27 article-title: Coumarin: a Privileged scaffold for the design and development of antineurodegenerative agents publication-title: Chem. Biol. Drug Des. doi: 10.1111/cbdd.12629 – volume: 31 start-page: 23 year: 2016 ident: 10.1016/j.ejphar.2020.173137_bib22 article-title: Synthesis, cytotoxic, anti-lipoxygenase and anti-acetylcholinesterase capacities of novel derivatives from harmine publication-title: J. Enzym. Inhib. Med. Chem. doi: 10.3109/14756366.2016.1163342 – volume: 331 start-page: 1286 year: 1994 ident: 10.1016/j.ejphar.2020.173137_bib8 article-title: Transforming growth factor β in tissue fibrosis publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199411103311907 – volume: 135 start-page: e146 issue: 10 year: 2017 ident: 10.1016/j.ejphar.2020.173137_bib6 article-title: Heart disease and stroke statistics 2017 up-date: a report from the American Heart Association publication-title: Circulation doi: 10.1161/CIR.0000000000000485 – start-page: 1 year: 2013 ident: 10.1016/j.ejphar.2020.173137_bib45 article-title: Synthesis and conformational assignment of N-(E)-stilbenyloxymethylenecarbonyl-substituted hydrazones of acetone and ortho-, meta- and para-chloro-(nitro-)benzaldehydes by means of and NMR spectroscopy publication-title: J. Spectroscopy doi: 10.1155/2013/197475 – volume: 76 start-page: 153 year: 2007 ident: 10.1016/j.ejphar.2020.173137_bib4 article-title: Protective effect of n-3 polyunsaturated fatty acids concentrate on isoproterenol induced myocardial infarction in rats publication-title: Prostaglandins Leukot. Essent. Fatty Acids doi: 10.1016/j.plefa.2006.12.002 – volume: 9 start-page: 675 year: 2014 ident: 10.1016/j.ejphar.2020.173137_bib48 article-title: Rapid molecular detection of salmonella typhi and salmonella paratyphi by polymerase chain reaction publication-title: Asian J. Microbiol. Biotechnol. Environ. Sci. – volume: 45 start-page: 660 year: 2009 ident: 10.1016/j.ejphar.2020.173137_bib19 article-title: Tautomerism and conformational isomerism of mercaptoacetylhydrazones of aliphatic and aromatic aldehydes publication-title: Russ. J. Org. Chem. doi: 10.1134/S1070428009050030 – volume: 104 start-page: 542 year: 2018 ident: 10.1016/j.ejphar.2020.173137_bib5 article-title: Paradoxical effects of atorvastatin in isoproterenol-induced cardiotoxicity in rats: role of oxidative stress and inflammation publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2018.05.005 |
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| SubjectTerms | (E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide ACE Action Potentials - drug effects Angiotensin-Converting Enzyme Inhibitors - chemical synthesis Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - pharmacology Biomarkers - blood Cardiotoxicity Chemical Sciences Disease Models, Animal Fibrinogen - metabolism Fibrinolytic Agents - chemical synthesis Fibrinolytic Agents - pharmacology Heart Rate - drug effects Hydrazones - chemical synthesis Hydrazones - pharmacology Isoproterenol Life Sciences Lipids - blood Male Myocardial infarction Myocardial Infarction - chemically induced Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Myocardial Infarction - prevention & control Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Necrosis Rats, Wistar Thrombolytic Ventricular Remodeling - drug effects |
| Title | (E)-N’-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide protecting rat heart tissues from isoproterenol toxicity: Evidence from in vitro and in vivo tests |
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