Detection and localization of early- and late-stage cancers using platelet RNA
Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show...
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| Vydáno v: | Cancer cell Ročník 40; číslo 9; s. 999 |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
12.09.2022
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| ISSN: | 1878-3686, 1878-3686 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
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| Abstract | Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I-IV cancer patients and in half of 352 stage I-III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening. |
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| AbstractList | Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I-IV cancer patients and in half of 352 stage I-III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening.Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I-IV cancer patients and in half of 352 stage I-III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening. Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I-IV cancer patients and in half of 352 stage I-III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening. |
| Author | van Wilpe, Sandra Teunissen, Charlotte E Lee-Lewandrowski, Elizabeth de Langen, Adrianus J Griffioen, Arjan W Łojkowska, Anna Nijhof, Inger Lewandrowski, Kent B Tjon Kon Fat, Lee-Ann Łapińska-Szumczyk, Sylwia Vancura, Adrienne Niemeijer, Anna-Larissa N Kamphuis, Maarten J Arkani, Mohammad D'Ambrosi, Silvia Hoeben, Ann Kuijpers, Marijke J E Visser, Lisanne E Sistermans, Erik A Pasterkamp, Gerard Verdonck-de Leeuw, Irma M Schalken, Jack A Mateen, Farrah Kraaijeveld, Adriaan O Killestein, Joep Drees, Esther E E Hiltermann, T Jeroen N Tannous, Jihane Smits, A Josien Roos, Eva Lokhorst, Henk Piek, Jurgen M J van der Lelij, Ewoud J Gerritsen, Winald Harting, Romee Langendijk, Johannes A van de Donk, Niels W C J Pegtel, D Michiel Bahce, Idris Verschueren, Heleen Vermunt, Lisa Steeghs, Neeltje Gregory, Annemijn Terhaard, Chris H J Kazemier, Geert Schweiger, Markus W Muller, Mirte Mantini, Giulia Besselink, Marc G Brakenhoff, Ruud H Prins, Henk-Jan Verheul, Henk M Post, Edward Ramaker, Jip Baatenburg de Jong, Robert J Leurs, Cyra E de Mast, Quirijn L |
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Center of Gynaecologic Oncology Amsterdam, the Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, the Netherlands – sequence: 90 givenname: Jurgen M J surname: Piek fullname: Piek, Jurgen M J organization: Department of Obstetrics and Gynaecology and Catharina Cancer Institute, Catharina Hospital, Eindhoven, the Netherlands – sequence: 91 givenname: Neeltje surname: Steeghs fullname: Steeghs, Neeltje organization: Department of Medical Oncology, the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands; Department of Clinical Pharmacology, the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands – sequence: 92 givenname: Winan J surname: van Houdt fullname: van Houdt, Winan J organization: Department of Surgical Oncology, the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands – sequence: 93 givenname: Ruud H surname: Brakenhoff fullname: Brakenhoff, Ruud H organization: Cancer Center Amsterdam and Liquid Biopsy Center, Amsterdam, the Netherlands; Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Otolaryngology and Head and Neck Surgery, Boelelaan 1117, Amsterdam, the Netherlands – sequence: 94 givenname: Gabe S surname: Sonke fullname: Sonke, Gabe S organization: Department of Medical Oncology, the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands – sequence: 95 givenname: Henk M surname: Verheul fullname: Verheul, Henk M organization: Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands – sequence: 96 givenname: Elisa surname: Giovannetti fullname: Giovannetti, Elisa organization: Cancer Center Amsterdam and Liquid Biopsy Center, Amsterdam, the Netherlands; Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Medical Oncology, Boelelaan 1117, Amsterdam, the Netherlands; Cancer Pharmacology Lab, AIRC Start-Up Unit, Fondazione Pisana per La Scienza, Pisa, Italy – sequence: 97 givenname: Geert surname: Kazemier fullname: Kazemier, Geert organization: Cancer Center Amsterdam and Liquid Biopsy Center, Amsterdam, the Netherlands; Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Surgery, Boelelaan 1117, Amsterdam, the Netherlands – sequence: 98 givenname: Siamack surname: Sabrkhany fullname: Sabrkhany, Siamack organization: Department of Physiology, Maastricht University, Maastricht, the Netherlands – sequence: 99 givenname: Ed surname: Schuuring fullname: Schuuring, Ed organization: Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands – sequence: 100 givenname: Erik A surname: Sistermans fullname: Sistermans, Erik A organization: Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Clinical Genetics, Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands |
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| Issue | 9 |
| Keywords | blood platelets RNA cancer early detection blood TEP liquid biopsy |
| Language | English |
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| PublicationTitle | Cancer cell |
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| References | 36472964 - Clin Chem Lab Med. 2022 Dec 02;61(6):e85-e86 |
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| Title | Detection and localization of early- and late-stage cancers using platelet RNA |
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