Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response

Previous work has demonstrated that microRNAs (miRNAs) change as a function of antidepressant treatment (ADT) response. However, it is unclear how representative these peripherally detected miRNA changes are to those occurring in the brain. This study aimed to use peripherally extracted neuron-deriv...

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Veröffentlicht in:	Molecular psychiatry Jg. 26; H. 12; S. 7417 - 7424
Hauptverfasser:	Saeedi, Saumeh, Nagy, Corina, Ibrahim, Pascal, Théroux, Jean-Francois, Wakid, Marina, Fiori, Laura M, Yang, Jennie, Rotzinger, Susan, Foster, Jane A, Mechawar, Naguib, Kennedy, Sidney H, Turecki, Gustavo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Nature Publishing Group 01.12.2021
Schlagworte:	Antidepressants Antidepressive Agents - metabolism Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Cell lines Citalopram Extracellular vesicles Extracellular Vesicles - genetics Extracellular Vesicles - metabolism Humans Immunoprecipitation MicroRNAs MicroRNAs - metabolism miRNA Neurons - metabolism Patients Plasma
ISSN:	1359-4184, 1476-5578, 1476-5578
Online-Zugang:	Volltext
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